Patterns of organic contaminants in marine mammals with reference to sperm whale strandings

Discriminant analysis has been applied to organochlorine contaminant data from a small number (ca 3-25) of 12 different marine mammal species to discriminate between the species on the basis of the chlorobiphenyls (CB) patterns in blubber and account for the effects of age, sex, condition and location of the mammals. The raw data are normalised to a single congener, CB 153, to reduce the effects of life history and sex, after which the discriminant factors are plotted to display the differences between species in relation to the intake and the metabolism of chlorobiphenyls. An understanding of these differences gives a better knowledge of the relative sensibility of these species. The sperm whales were found to have the least ability to metabolise CBs when compared with other cetaceans, although the concentration range observed for total CB was relatively low (265-6,313 µg/kg lipid weight)

Using digital devices in a first year classroom: a focus on the design and use of phonics software applications

When integrated within a holistic literacy program, phonics applications can be used in classrooms to facilitate students’ self-directed learning of letter-sound knowledge; but are they designed to allow for such a purpose? With most phonics software applications making heavy use of image cues, this project has more specifically investigated whether the design of the images used in such applications may impact on the effectiveness of their self-directed use in classrooms. Using a quasi-experimental study, we compared two types of pictorial mnemonics used in tablet applications, along with teacher-led activity in three first-year classrooms from the one school. The difference between teacher-led activity and integrated picture cues was significant, with teacher-led activity proving more effective. The difference between teacher-led activity and form-taking picture cues, however, was not statistically significant. Given that the outcomes of this small-scale study suggest that image design may be a significant design feature contributing to the educational value of using phonics applications in the classroom, we recommend that the design features of phonics software applications attract further research

Quasiparticle vanishing driven by geometrical frustration

We investigate the single hole dynamics in the triangular t-J model. We study the structure of the hole spectral function, assuming the existence of a 120 magnetic Neel order. Within the self-consistent Born approximation (SCBA) there is a strong momentum and t sign dependence of the spectra, related to the underlying magnetic structure and the particle-hole asymmetry of the model. For positive t, and in the strong coupling regime, we find that the low energy quasiparticle excitations vanish outside the neighbourhood of the magnetic Goldstone modes; while for negative t the quasiparticle excitations are always well defined. In the latter, we also find resonances of magnetic origin whose energies scale as (J/t)^2/3 and can be identified with string excitations. We argue that this complex structure of the spectra is due to the subtle interplay between magnon-assisted and free hopping mechanisms. Our predictions are supported by an excellent agreement between the SCBA and the exact results on finite size clusters. We conclude that the conventional quasiparticle picture can be broken by the effect of geometrical magnetic frustration.Comment: 6 pages, 7 figures. Published versio

Torsion of a cylinder of partially molten rock with a spherical inclusion: Theory and simulation

The processes that are involved in migration and extraction of melt from the mantle are not yet fully understood. Gaining a better understanding of material properties of partially molten rock could help shed light on the behavior of melt on larger scales in the mantle. In this study, we simulate three-dimensional torsional deformation of a partially molten rock that contains a rigid, spherical inclusion. We compare the computed porosity patterns to those found in recent laboratory experiments. The laboratory experiments show emergence of melt-rich bands throughout the rock sample, and pressure shadows around the inclusion. The numerical model displays similar melt-rich bands only for a small bulk-to-shear-viscosity ratio (five or less). The results are consistent with earlier two-dimensional numerical simulations; however, we show that it is easier to form melt-rich bands in three dimensions compared to two. The addition of strain-rate dependence of the viscosity causes a distinct change in the shape of pressure shadows around the inclusion. This change in shape presents an opportunity for experimentalists to identify the strain-rate dependence and therefore the dominant deformation mechanism in torsion experiments with inclusions.This work was supported by the UK Natural Environment Research Council under grants NE/I023929/1 and NE/I026995/1. Computations were performed on the ARCHER UK National Supercomputing Service (http://www.archer.ac.uk). We thank Chris Richardson for all his support with running the simulations on ARCHER. Katz thanks the Leverhulme Trust for support.This is the author accepted manuscript. The final version is available from Wiley via http://dx.doi.org/10.1002/2015GC00606

Talking textiles, making value: Catalysing fashion, dress, and textiles heritage in the Midlands

This is an accepted manuscript of an article published by Taylor & Francis in Journal of Textile Design Research and Practice on 11/11/2019, available online: https://www.tandfonline.com/doi/full/10.1080/20511787.2019.1682909 The accepted version of the publication may differ from the final published version.There are hundreds of small museums, archives, and collections in the English Midlands, United Kingdom (UK), many of which are the legacy of the region’s rich industrial heritage. A surprising number of these include dress and textiles in various forms, from the costume collection of Charles Paget-Wade at Berrington Hall (Leominster) to intricately stitched smocks made by local needlewomen in Herefordshire, and the wealth of manufacturers’ samples that comprise the silk ribbon trade archive at the Herbert Museum, Coventry. These are challenging times for many such organisations as they face cutbacks in staff and local authority funding. Yet they offer a unique and largely unexploited resource for staff, students, and researchers in art and design higher education (HE), not only for primary research but also as a catalyst for design innovation. The discussion here, which takes the format of group research practitioner interview, builds on a Knowledge Exchange event that was held December 2017 at the Fashion Lab, University of Wolverhampton (UoW). The event brought together a diverse group of fashion and textiles professionals to talk, exchange ideas, take part in object handling sessions, mind-map, and brain-storm how to catalyse connections between heritage collections and higher education and build value. With seed funding from the Museum-University Partnership Initiative (MUPI) (see National Co-ordinating Centre for Public Engagement - NCCPE 2019), the day built on a series of scoping visits to collections in the region undertaken by Professor Fiona Hackney and Dr Emily Baines. The group involved staff, students and museum professionals including those from UoW, De Montfort University (DMU), Hereford College of Arts (HCA), Nottingham Trent University (NTU), artist Ruth Singer who leads the Arts Council-funded Criminal Quilts project in association with Staffordshire Record Office (Singer 2019), and representatives from Herefordshire Museum Service, the Herbert Gallery (Coventry), Walsall Museums Service, the Lace Guild Stourbridge, and Ironbridge Gorge Museum Trust. The following conversation reflects themes that emerged in the project including: the need to embed archival work and primary research in fashion and textiles curricula at all levels, the development of hubs to connect university research with museum practice, the added value of artist-led projects, and the significance of place-based textiles heritage as a catalyst for new business and sustainable design practice

Post-malnutrition growth and its associations with child survival and non-communicable disease risk: A secondary analysis of the Malawi 'ChroSAM' cohort

OBJECTIVE: Explore patterns of post-malnutrition growth (PMGr) during and after treatment for severe malnutrition, and describe associations with survival and non-communicable disease (NCD) risk seven years post-treatment. DESIGN: Six indicators of PMGr were derived based on a variety of timepoints, weight, weight-for-age z-score (WAZ) and height-for-age z-score (HAZ). Three categorisation methods included: no categorisation, quintiles, and latent class analysis (LCA). Associations with mortality risk, and seven NCD indicators were analysed. SETTING: Secondary data from Blantyre, Malawi between 2006 and 2014. PARTICIPANTS: A cohort of 1024 children treated for severe malnutrition (weight-for-length z-score <70% median and/or MUAC<110 mm and/or bilateral oedema) at aged 5 to 168 months. RESULTS: Faster weight gain during treatment (g/day) and after treatment (g/kg/day) were associated with lower risk of death (aOR 0.99, 95%CI 0.99 to 1.00; and aOR 0.91, 95% CI 0.87 to 0.94 respectively). In survivors (mean age 9 years), it was associated with greater hand grip strength (0.02, 95%CI 0.00 to 0.03) and larger HAZ (6.62, 95%CI 1.31 to 11.9), both indicators of better health. However, faster weight gain was also associated with increased waist:hip ratio (0.02, 95%CI 0.01 to 0.03), an indicator of later life NCD risk. The clearest patterns of association were seen when defining PMGr based on weight gain in g/day during treatment and using the LCA method to describe growth patterns. Weight deficit at admission was a major confounder. CONCLUSIONS: A complex pattern of benefits and risks is associated with faster PMGr. Both initial weight deficit and rate of weight gain have important implications for future health

The contribution of metacognitions and attentional control to decisional procrastination

Earlier research has implicated metacognitions and attentional control in procrastination and self-regulatory failure. This study tested several hypotheses: (1) that metacognitions would be positively correlated with decisional procrastination; (2) that attentional control would be negatively correlated with decisional procrastination; (3) that metacognitions would be negatively correlated with attentional control; and (4) that metacognitions and attentional control would predict decisional procrastination when controlling for negative affect. One hundred and twenty-nine participants completed the Depression Anxiety Stress Scale 21, the Meta-Cognitions Questionnaire 30, the Attentional Control Scale, and the Decisional Procrastination Scale. Significant relationships were found between all three attentional control factors (focusing, shifting, and flexible control of thought) and two metacognitions factors (negative beliefs concerning thoughts about uncontrollability and danger, and cognitive confidence). Results also revealed that decisional procrastination was significantly associated with negative affect, all measured metacognitions factors, and all attentional control factors. In the final step of a hierarchical regression analysis only stress, cognitive confidence, and attention shifting were independent predictors of decisional procrastination. Overall these findings support the hypotheses and are consistent with the Self-Regulatory Executive Function model of psychological dysfunction. The implications of these findings are discussed

Fine tuning Exo2, a small molecule inhibitor of secretion and retrograde trafficking pathways in mammalian cells

The small molecule 4-hydroxy-3-methoxybenzaldehyde (5,6,7,8-tetrahydro[1]benzothieno[2,3- d]pyrimidin-4-yl)hydrazone (Exo2) stimulates morphological changes at the mammalian Golgi and trans-Golgi network that are virtually indistinguishable from those induced by brefeldin A. Both brefeldin A and Exo2 protect cells from intoxication by Shiga(-like) toxins by acting on other targets that operate at the early endosome, but do so at the cost of high toxicity to target cells. The advantage of Exo2 is that it is much more amenable to chemical modification and here we report a range of Exo2 analogues produced by modifying the tetrahydrobenzothienopyrimidine core, the vanillin moiety and the hydrazone bond that links these two. These compounds were examined for the morphological changes they stimulated at the Golgi stack, the trans Golgi network and the transferrin receptor-positive early endosomes and this activity correlated with their inherent toxicity towards the protein manufacturing ability of the cell and their protective effect against toxin challenge. We have developed derivatives that can separate organelle morphology, target specificity, innate toxicity and toxin protection. Our results provide unique compounds with low toxicity and enhanced specificity to unpick the complexity of membrane trafficking networks

Tissue-Specific Orchestration of Gilthead Sea Bream Resilience to Hypoxia and High Stocking Density

Two different O-2 levels (normoxia: 75-85% O-2 saturation; moderate hypoxia: 42-43% O-2 saturation) and stocking densities (LD: 9.5, and HD: 19 kg/m(3)) were assessed on gilthead sea bream (Sparus aurata) in a 3-week feeding trial. Reduced O-2 availability had a negative impact on feed intake and growth rates, which was exacerbated by HD despite of the improvement in feed efficiency. Blood physiological hallmarks disclosed the enhancement in O-2-carrying capacity in fish maintained under moderate hypoxia. This feature was related to a hypo-metabolic state to cope with a chronic and widespread environmental O-2 reduction, which was accompanied by a differential regulation of circulating cortisol and growth hormone levels. Customized PCR-arrays were used for the simultaneous gene expression profiling of 34-44 selected stress and metabolic markers in liver, white skeletal muscle, heart, and blood cells. The number of differentially expressed genes ranged between 22 and 19 in liver, heart, and white skeletal muscle to 5 in total blood cells. Partial Least-Squares Discriminant Analysis (PLS-DA) explained [R2Y(cum)] and predicted [Q2Y(cum)] up to 95 and 65% of total variance, respectively. The first component (R2Y = 0.2889) gathered fish on the basis of O-2 availability, and liver and cardiac genes on the category of energy sensing and oxidative metabolism (cs, hif-1 alpha, pgc1 alpha, pgc1 beta, sirts 1-2-4-5-6-7), antioxidant defense and tissue repair (prdx5, sod2, mortalin, gpx4, gr, grp-170, and prdx3) and oxidative phosphorylation (nd2, nd5, and coxi) highly contributed to this separation. The second component (R2Y = 0.2927) differentiated normoxic fish at different stocking densities, and the white muscle clearly promoted this separation by a high over-representation of genes related to GH/IGF system (ghr-i, igfbp6b, igfbp5b, insr, igfbp3, and igf-i). The third component (R2Y = 0.2542) discriminated the effect of stocking density in fish exposed to moderate hypoxia by means of hepatic fatty acid desaturases (fads2, scd1a, and scd1b) and muscle markers of fatty acid oxidation (cpt1a). All these findings disclose the different contribution of analyzed tissues (liver >= heart > muscle > blood) and specific genes to the hypoxic- and crowding stress-mediated responses. This study will contribute to better explain and understand the different stress resilience of farmed fish across individuals and species