525 research outputs found
An Energy Feedback System for the MIT/Bates Linear Accelerator
We report the development and implementation of an energy feedback system for
the MIT/Bates Linear Accelerator Center. General requirements of the system are
described, as are the specific requirements, features, and components of the
system unique to its implementation at the Bates Laboratory. We demonstrate
that with the system in operation, energy fluctuations correlated with the 60
Hz line voltage and with drifts of thermal origin are reduced by an order of
magnitude
A High Power Hydrogen Target for Parity Violation Experiments
Parity-violating electron scattering measurements on hydrogen and deuterium,
such as those underway at the Bates and CEBAF laboratories, require
luminosities exceeding cms, resulting in large beam
power deposition into cryogenic liquid. Such targets must be able to absorb 500
watts or more with minimal change in target density. A 40~cm long liquid
hydrogen target, designed to absorb 500~watts of beam power without boiling,
has been developed for the SAMPLE experiment at Bates. In recent tests with
40~A of incident beam, no evidence was seen for density fluctuations in
the target, at a sensitivity level of better than 1\%. A summary of the target
design and operational experience will be presented.Comment: 13 pages, 9 postscript figure
The Strange Quark Contribution to the Proton's Magnetic Moment
We report a new determination of the strange quark contribution to the
proton's magnetic form factor at a four-momentum transfer Q2 = 0.1 (GeV/c)^2
from parity-violating e-p elastic scattering. The result uses a revised
analysis of data from the SAMPLE experiment which was carried out at the
MIT-Bates Laboratory. The data are combined with a calculation of the proton's
axial form factor GAe to determine the strange form factor GMs(Q2=0.1)=0.37 +-
0.20 +- 0.26 +- 0.07. The extrapolation of GMs to its Q2=0 limit and comparison
with calculations is also discussed.Comment: 6 pages, 1 figure, submitted to Phys. Lett.
In depth analysis of kinase cross screening data to identify CaMKK2 inhibitory scaffolds
The calcium/calmodulinâdependent protein kinase kinase 2 (CAMKK2) activates CAMK1, CAMK4, AMPK, and AKT, leading to numerous physiological responses. The deregulation of CAMKK2 is linked to several diseases, suggesting the utility of CAMKK2 inhibitors for oncological, metabolic and inflammatory indications. In this work, we demonstrate that STOâ609, frequently described as a selective inhibitor for CAMKK2, potently inhibits a significant number of other kinases. Through an analysis of literature and public databases, we have identified other potent CAMKK2 inhibitors and verified their activities in differential scanning fluorimetry and enzyme inhibition assays. These inhibitors are potential starting points for the development of selective CAMKK2 inhibitors and will lead to tools that delineate the roles of this kinase in disease biology.252CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTĂFICO E TECNOLĂGICO - CNPQFUNDAĂĂO DE AMPARO Ă PESQUISA DO ESTADO DE SĂO PAULO - FAPESP465651/2014-32013/50724-5; 2014/50897-0; 2019/14275-
Parity Violation in Elastic Electron-Proton Scattering and the Proton's Strange Magnetic Form Factor
We report a new measurement of the parity-violating asymmetry in elastic electron scattering from the proton at backward scattering angles. This asymmetry is sensitive to the strange magnetic form factor of the proton as well as electroweak axial radiative corrections. The new measurement of A = -4.92±0.61±0.73 ppm provides a significant constraint on these quantities. The implications for the strange magnetic form factor are discussed in the context of theoretical estimates for the axial corrections
Cerebral blood flow and cognitive performance in postural tachycardia syndrome: insights from sustained cognitive stress test
BACKGROUND: The physiology underlying "brain fog" in the absence of orthostatic stress in postural tachycardia syndrome(POTS) remains poorly understood. METHODS AND RESULTS: We evaluated cognitive and hemodynamic responses (cardiovascular and cerebral: heart rate, blood pressure, end-tidal carbon dioxide, and cerebral blood flow velocity (CBFv) in the middle cerebral artery at baseline, after initial cognitive testing, and after (30-minutes duration) prolonged cognitive stress test (PCST) whilst seated; as well as after 5-minute standing in consecutively enrolled participants with POTS (n=22) and healthy controls (n=18). Symptom severity was quantified with orthostatic hypotensive questionnaire at baseline and end of study. Subjects in POTS and control groups were frequency age- and sex-matched (29±11 versus 28±13 years; 86 versus 72% women, respectively; both Pâ„0.4). The CBFv decreased in both groups (condition, P=0.04) following PCST, but a greater reduction in CBFv was observed in the POTS versus control group (â7.8% versus â1.8%; interaction, P=0.038). Notably, the reduced CBFv following PCST in the POTS group was similar to that seen during orthostatic stress (60.0±14.9 versus 60.4±14.8 cm/s). Further, PCST resulted in greater slowing in psychomotor speed (6.1% versus 1.4%, interaction, P=0.027) and a greater increase in symptom scores at study completion (interaction, P0.05). CONCLUSIONS: Reduced CBFv and cognitive dysfunction were evident in patients with POTS following prolonged cognitive stress even in the absence of orthostatic stress.Rachel Wells, Varun Malik, Anthony G. Brooks, Dominik Linz, Adrian D. Elliott, Prashanthan Sanders ... et al
CONFIDENCE overview of improvements in radioecological human food chain models and future needs
Radioecological models used to make predictions of the radionuclide activity concentrations in human foodstuffs must be sufficiently robust and fit for purpose with uncertainties reduced where practicable. The CONFIDENCE project had a work package with the objective to improve the capabilities of radioecological models and this paper presents the key findings of this work. Recommendations for future radioecological studies/model developments are made based on the findings of the work conducted and consultations with end-users
Electronic localization at mesoscopic length scales: different definitions of localization and contact effects in a heuristic DNA model
In this work we investigate the electronic transport along model DNA
molecules using an effective tight-binding approach that includes the backbone
on site energies. The localization length and participation number are examined
as a function of system size, energy dependence, and the contact coupling
between the leads and the DNA molecule. On one hand, the transition from an
diffusive regime to a localized regime for short systems is identified,
suggesting the necessity of a further length scale revealing the system borders
sensibility. On the other hand, we show that the lenght localization and
participation number, do not depended of system size and contact coupling in
the thermodynamic limit. Finally we discuss possible length dependent origins
for the large discrepancies among experimental results for the electronic
transport in DNA sample
Parity-violating Electron Deuteron Scattering and the Proton's Neutral Weak Axial Vector Form Factor
We report on a new measurement of the parity-violating asymmetry in
quasielastic electron scattering from the deuteron at backward angles at Q2=
0.038 (GeV/c)2. This quantity provides a determination of the neutral weak
axial vector form factor of the nucleon, which can potentially receive large
electroweak corrections. The measured asymmetry A=-3.51 +/- 0.57(stat) +/-
0.58(sys)ppm is consistent with theoretical predictions. We also report on
updated results of the previous experiment at Q2=0.091 (GeV/c)2, which are also
consistent with theoretical predictions.Comment: 4 pages, 2 figures, submitted to Phys. Rev. Let
Transverse Beam Spin Asymmetries in Forward-Angle Elastic Electron-Proton Scattering
We have measured the beam-normal single-spin asymmetry in elastic scattering
of transversely-polarized 3 GeV electrons from unpolarized protons at Q^2 =
0.15, 0.25 (GeV/c)^2. The results are inconsistent with calculations solely
using the elastic nucleon intermediate state, and generally agree with
calculations with significant inelastic hadronic intermediate state
contributions. A_n provides a direct probe of the imaginary component of the
2-gamma exchange amplitude, the complete description of which is important in
the interpretation of data from precision electron-scattering experiments.Comment: 5 pages, 3 figures, submitted to Physical Review Letters; shortened
to meet PRL length limit, clarified some text after referee's comment
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