Examining Appropriacy of CFI and TLI Cutoff Value in Multiple-Group CFA Test of Measurement Invariance to Enhance Accuracy of Test Score Interpretation

The most common effect size when using a multiple-group confirmatory factor analysis approach to measurement invariance is ΔCFI and ΔTLI with a cutoff value of 0.01. However, this recommended cutoff value may not be ubiquitously appropriate and may be of limited application for some tests (e.g., measures using dichotomous items or different estimation methods, sample sizes, or model complexity). Moreover, prior cutoff value estimations often have ignored consequences resulting in using measures that more accurately estimate countries’ or learners’ proficiency for some countries or groups versus others. In this study, we investigate whether the cutoff value proposed by Cheung and Rensvold (ΔCFI or ΔTLI \u3e 0.01) is appropriate across educational measurement contexts. Specifically, we investigated the performance of ΔCFI and ΔTLI in capturing LOI at the scalar level in dichotomous items within item response theory on groups whose test characteristic curves differed by 0.5. Simulation results showed that the proposed cutoff value of 0.01 in ΔCFI and ΔTLI was not appropriate to capture LOI under the study conditions, which may result in the misinterpretation of test results or inaccurate inferences

Effect of Adjusting Pseudo-Guessing Parameter Estimates on Test Scaling When Item Parameter Drift Is Present

In item response theory test scaling/equating with the three-parameter model, the scaling coefficients A and B have no impact on the c-parameter estimates of the test items since the c-parameter estimates are not adjusted in the scaling/equating procedure. The main research question in this study concerned how serious the consequences would be if c-parameter estimates are not adjusted in the test equating procedure when item-parameter drift (IPD) is present. This drift is commonly observed in equating studies and hence, has been the source of considerable research. The results from a series of Monte-Carlo simulation studies conducted under 32 different combinations of conditions showed that some calibration strategies in the study, where the c-parameters were adjusted to be identical across two test forms, resulted in more robust equating performance in the presence of IPD. This paper discusses the practical effectiveness and the theoretical importance of appropriately adjusting c-parameter estimates in equating. Accessed 3,754 times on https://pareonline.net from July 04, 2015 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right

F-theory, GUTs, and the Weak Scale

In this paper we study a deformation of gauge mediated supersymmetry breaking in a class of local F-theory GUT models where the scale of supersymmetry breaking determines the value of the mu term. Geometrically correlating these two scales constrains the soft SUSY breaking parameters of the MSSM. In this scenario, the hidden SUSY breaking sector involves an anomalous U(1) Peccei-Quinn symmetry which forbids bare mu and B mu terms. This sector typically breaks supersymmetry at the desired range of energy scales through a simple stringy hybrid of a Fayet and Polonyi model. A variant of the Giudice-Masiero mechanism generates the value mu ~ 10^2 - 10^3 GeV when the hidden sector scale of supersymmetry breaking is F^(1/2) ~ 10^(8.5) GeV. Further, the B mu problem is solved due to the mild hierarchy between the GUT scale and Planck scale. These models relate SUSY breaking with the QCD axion, and solve the strong CP problem through an axion with decay constant f_a ~ M_(GUT) * mu / L, where L ~ 10^5 GeV is the characteristic scale of gaugino mass unification in gauge mediated models, and the ratio \mu / L ~ M_(GUT)/M_(pl) ~ 10^(-3). We find f_a ~ 10^12 GeV, which is near the high end of the phenomenologically viable window. Here, the axino is the goldstino mode which is eaten by the gravitino. The gravitino is the LSP with a mass of about 10^1 - 10^2 MeV, and a bino-like neutralino is (typically) the NLSP with mass of about 10^2 - 10^3 GeV. Compatibility with electroweak symmetry breaking also determines the value of tan(beta) ~ 30 +/- 7.Comment: v3: 94 pages, 9 figures, clarification of Fayet-Polonyi model and instanton corrections to axion potentia

Patients’ Experiences of a Sarcoma Diagnosis: A Process Mapping Exercise of Diagnostic Pathways

Patients with sarcoma often report prolonged time to diagnosis, which is attributed to the rarity of sarcoma and the low awareness of pre-diagnostic signs and symptoms. Aims: To describe patients’ experiences of pre-diagnostic signs/symptoms and pathways to diagnosis, including where help was sought, and the processes involved. Methods: Mixed methods involving quantitative, qualitative and inductive thematic analyses using novel process mapping of patient journey data, as reported by the patients. We examined the time from symptom onset to first professional presentation (patient interval, PI), first consultation to diagnostic biopsy, first consultation to diagnosis (diagnostic interval) and first presentation to diagnosis (total interval). Results: A total of 87 interviews were conducted over 5 months in 2017. Of these, 78 (40 males/38 females) were included. The sarcoma subtypes were bone (n = 21), soft tissue (n = 41), head and neck (n = 9) and gastro-intestinal (GIST; n = 7). Age at diagnosis was 13–24 (n = 7), 25–39 (n = 23), 40–64 (n = 34) and 65+ (n = 14) years. The median PI was 13 days (1–4971) and similar between sarcoma subtypes, with the exception of GIST (mPI = 2 days, (1–60). The longest mPI (31 days, range 4–762) was for those aged 13–24 years. The median diagnostic interval was 87.5 (range 0–5474 days). A total of 21 patients were misdiagnosed prior to diagnosis and symptoms were commonly attributed to lifestyle factors. Conclusions: Prolonged times to diagnosis were experienced by the majority of patients in our sample. Further research into the evolution of pre-diagnostic sarcoma symptoms is required to inform awareness interventions

Supersymmetry with Light Stops

Recent LHC data, together with the electroweak naturalness argument, suggest that the top squarks may be significantly lighter than the other sfermions. We present supersymmetric models in which such a split spectrum is obtained through "geometries": being "close to" electroweak symmetry breaking implies being "away from" supersymmetry breaking, and vice versa. In particular, we present models in 5D warped spacetime, in which supersymmetry breaking and Higgs fields are located on the ultraviolet and infrared branes, respectively, and the top multiplets are localized to the infrared brane. The hierarchy of the Yukawa matrices can be obtained while keeping near flavor degeneracy between the first two generation sfermions, avoiding stringent constraints from flavor and CP violation. Through the AdS/CFT correspondence, the models can be interpreted as purely 4D theories in which the top and Higgs multiplets are composites of some strongly interacting sector exhibiting nontrivial dynamics at a low energy. Because of the compositeness of the Higgs and top multiplets, Landau pole constraints for the Higgs and top couplings apply only up to the dynamical scale, allowing for a relatively heavy Higgs boson, including m_h = 125 GeV as suggested by the recent LHC data. We analyze electroweak symmetry breaking for a well-motivated subset of these models, and find that fine-tuning in electroweak symmetry breaking is indeed ameliorated. We also discuss a flat space realization of the scenario in which supersymmetry is broken by boundary conditions, with the top multiplets localized to a brane while other matter multiplets delocalized in the bulk.Comment: 27 pages, 7 figure

Cytochrome P450-derived epoxyeicosatrienoic acids and coronary artery disease in humans: a targeted metabolomics study

Cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) exhibit potent cardiovascular protective effects in preclinical models, and promoting the effects of EETs has emerged as a potential therapeutic strategy for coronary artery disease (CAD). The relationship between circulating EET levels and CAD extent in humans, however, remains unknown. A panel of free (unesterified) plasma eicosanoid metabolites was quantified in 162 patients referred for coronary angiography, and associations with extent of CAD [no apparent CAD (N = 39), nonobstructive CAD (N = 51), and obstructive CAD (N = 72)] were evaluated. A significant relationship between free EET levels and CAD extent was observed (P = 0.003) such that the presence of obstructive CAD was associated with lower circulating EET levels. This relationship was confirmed in multiple regression analysis where CAD extent was inversely and significantly associated with EET levels (P = 0.013), and with a biomarker of EET biosynthesis (P < 0.001), independent of clinical and demographic factors. Furthermore, quantitative enrichment analysis revealed that these associations were the most pronounced compared with other eicosanoid metabolism pathways. Collectively, these findings suggest that the presence of obstructive CAD is associated with lower EET metabolite levels secondary to suppressed EET biosynthesis. Novel strategies that promote the effects of EETs may have therapeutic promise for patients with obstructive CAD

Bartonella species detection in captive, stranded and free-ranging cetaceans

We present prevalence of Bartonella spp. for multiple cohorts of wild and captive cetaceans. One hundred and six cetaceans including 86 bottlenose dolphins (71 free-ranging, 14 captive in a facility with a dolphin experiencing debility of unknown origin, 1 stranded), 11 striped dolphins, 4 harbor porpoises, 3 Risso's dolphins, 1 dwarf sperm whale and 1 pygmy sperm whale (all stranded) were sampled. Whole blood (n = 95 live animals) and tissues (n = 15 freshly dead animals) were screened by PCR (n = 106 animals), PCR of enrichment cultures (n = 50 animals), and subcultures (n = 50 animals). Bartonella spp. were detected from 17 cetaceans, including 12 by direct extraction PCR of blood or tissues, 6 by PCR of enrichment cultures, and 4 by subculture isolation. Bartonella spp. were more commonly detected from the captive (6/14, 43%) than from free-ranging (2/71, 2.8%) bottlenose dolphins, and were commonly detected from the stranded animals (9/21, 43%; 3/11 striped dolphins, 3/4 harbor porpoises, 2/3 Risso's dolphins, 1/1 pygmy sperm whale, 0/1 dwarf sperm whale, 0/1 bottlenose dolphin). Sequencing identified a Bartonella spp. most similar to B. henselae San Antonio 2 in eight cases (4 bottlenose dolphins, 2 striped dolphins, 2 harbor porpoises), B. henselae Houston 1 in three cases (2 Risso's dolphins, 1 harbor porpoise), and untyped in six cases (4 bottlenose dolphins, 1 striped dolphin, 1 pygmy sperm whale). Although disease causation has not been established, Bartonella species were detected more commonly from cetaceans that were overtly debilitated or were cohabiting in captivity with a debilitated animal than from free-ranging animals. The detection of Bartonella spp. from cetaceans may be of pathophysiological concern

Heavy Squarks at the LHC

The LHC, with its seven-fold increase in energy over the Tevatron, is capable of probing regions of SUSY parameter space exhibiting qualitatively new collider phenomenology. Here we investigate one such region in which first generation squarks are very heavy compared to the other superpartners. We find that the production of these squarks, which is dominantly associative, only becomes rate-limited at mSquark > 4(5) TeV for L~10(100) fb-1. However, discovery of this scenario is complicated because heavy squarks decay primarily into a jet and boosted gluino, yielding a dijet-like topology with missing energy (MET) pointing along the direction of the second hardest jet. The result is that many signal events are removed by standard jet/MET anti-alignment cuts designed to guard against jet mismeasurement errors. We suggest replacing these anti-alignment cuts with a measurement of jet substructure that can significantly extend the reach of this channel while still removing much of the background. We study a selection of benchmark points in detail, demonstrating that mSquark= 4(5) TeV first generation squarks can be discovered at the LHC with L~10(100)fb-1

Investigating the effect of independent blinded digital image assessment on the STOP GAP trial

Background Blinding is the process of keeping treatment assignment hidden and is used to minimise the possibility of bias. Trials at high risk of bias have been shown to report larger treatment effects than low risk studies. In dermatology, one popular method of blinding is to have independent outcome assessors who are unaware of treatment allocation assessing the end point using digital photographs. However, this can be complex, expensive and time-consuming. The objective of this study was to compare the effect of blinded and unblinded outcome assessment on the results of the STOP GAP trial. Methods The STOP GAP trial compared prednisolone to ciclosporin in treating pyoderma gangrenosum. Participants’ lesions were measured at baseline and 6 weeks to calculate the primary outcome, speed of healing. Independent blinded assessors obtained measurements from digital photographs using specialist software. In addition, unblinded treating clinicians estimated lesion area by measuring length and width. The primary outcome was determined using blinded measurements where available, otherwise unblinded measurements were used (method referred to as trial measurements). In this study, agreement between the trial and unblinded measurements was determined using the intraclass correlation coefficient (ICC). The STOP GAP primary analysis was repeated using unblinded measurements only. We introduced differential and non-differential error in unblinded measurements and investigated the effect on the STOP GAP primary analysis. Results 86 (80%) of the 108 patients were assessed using digital images. Agreement between trial and unblinded measurements was excellent (ICC=0.92 at baseline; 0.83 at 6 weeks). There was no evidence that the results of the trial primary analysis differed according to how the primary outcome was assessed (p-value for homogeneity = 1.00). Conclusions Blinded digital image assessment in STOP GAP did not meaningfully alter trial conclusions compared with unblinded assessment. However, as the process brought added accuracy and credibility to the trial it was considered worthwhile. These findings question the usefulness of digital image assessment in a trial with an objective outcome and where bias is not expected to be excessive. Further research should investigate if there are alternative, less complex ways of incorporating blinding in clinical trials

Physics at a 100 TeV pp collider: beyond the Standard Model phenomena

This report summarises the physics opportunities in the search and study of physics beyond the Standard Model at a 100 TeV pp collider.Comment: 196 pages, 114 figures. Chapter 3 of the "Physics at the FCC-hh" Repor