Pediatric T- and NK-cell lymphomas: new biologic insights and treatment strategies

T- and natural killer (NK)-cell lymphomas are challenging childhood neoplasms. These cancers have varying presentations, vast molecular heterogeneity, and several are quite unusual in the West, creating diagnostic challenges. Over 20 distinct T- and NK-cell neoplasms are recognized by the 2008 World Health Organization classification, demonstrating the diversity and potential complexity of these cases. In pediatric populations, selection of optimal therapy poses an additional quandary, as most of these malignancies have not been studied in large randomized clinical trials. Despite their rarity, exciting molecular discoveries are yielding insights into these clinicopathologic entities, improving the accuracy of our diagnoses of these cancers, and expanding our ability to effectively treat them, including the use of new targeted therapies. Here, we summarize this fascinating group of lymphomas, with particular attention to the three most common subtypes: T-lymphoblastic lymphoma, anaplastic large cell lymphoma, and peripheral T-cell lymphoma-not otherwise specified. We highlight recent findings regarding their molecular etiologies, new biologic markers, and cutting-edge therapeutic strategies applied to this intriguing class of neoplasms

Lawrence Welk Scrapbooks Collection, 1938-1981

The Lawrence Welk Scrapbook Collection is perhaps the single, most comprehensive collection documenting the career of Lawrence Welk from 1938 to 1981. However there is a significant gap between 1943 and 1950 and also 1954-1955. Whether scrapbooks were ever compiled the years of the gaps is not known. It is believed that Welk‟s sister Eva Welk compiled these early scrapbooks, possibly through 1953. From 1956 to 1981 the scrapbooks are complete. No scrapbooks were compiled after 1981. The scrapbooks from 1938 to 1953 have been photocopied and are available in a bound volume at the Institute Research Room. This was done due to the fragile condition of the originals

Lawrence Welk Sheet Music Collection, 1919-1966

The Lawrence Welk Sheet Music Collection includes single sheet music titles and a number of music books that either feature Lawrence Welk or members of his musical family on the cover or were composed and published by them. The vast majority of the titles are from the 1930s through 1950s. A photograph of Lawrence Welk is featured on many of the cover and often the phrase ‘Featured by Lawrence Welk and his Champagne Orchestra’ is printed on the cover also

Nobody knows how I love you, nobody cares the way I do [first line of chorus]

Performers: Lawrence WelkPiano, Voice and Chord

Must be that you\u27re an angel casting a spell on me [first line of chorus]

Performance Medium: Piano, Voice and Chord

All the states have answered freedom\u27s call; [first line of chorus]

Performers: Lawrence WelkPiano, Voice and Chord

How can I live without you when the world\u27s full of love [first line of chorus]

Performers: Lawrence WelkPiano, Voice and Chord