An initial implementation of multiagent simulation of travel behavior for a medium-sized city in China

Since the traditional four-step model is so simple that it cannot solve complex modern transportation problems, microsimulation is gradually applied for transportation planning and some researches indicate that it is more compatible and realistic. In this paper, a framework of agent-based simulation of travel behavior is proposed, which is realized by MATSim, a simulation tool developed for large-scale agent-based simulation. MATSim is currently developed and some of its models are under training, so a detailed introduction of simulation structure and preparation of input data will be presented. In practice, the preparation process differs from one to another in different simulation projects because the available data for simulation is various. Thus, a simulation of travel behavior under a condition of limited available survey data will be studied based on MATSim; furthermore, a medium-sized city in China will be taken as an example to check whether agent-based simulation of travel behavior can be successfully applied in China

Limits on the Weak Equivalence Principle and Photon Mass with FRB 121102 Subpulses

Fast radio bursts (FRBs) are short-duration (~millisecond) radio transients with cosmological origin. The simple sharp features of the FRB signal have been utilized to probe two fundamental laws of physics, namely, testing Einstein\u27s weak equivalence principle and constraining the rest mass of the photon. Recently, Hessels et al. found that after correcting for dispersive delay, some of the bursts in FRB 121102 have complex time–frequency structures that include subpulses with a time–frequency downward drifting property. Using the delay time between subpulses in FRB 121102, here we show that the parameterized post-Newtonian parameter γ is the same for photons with different energies to the level of ... (see full abstract in article)

Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy

Random-pattern skin flap transplantation is frequently applied in plastic and reconstructive surgery. However, the distal part of the flap often suffers necrosis due to ischemia. In this study, the effects of salvianolic acid B (Sal B) on flap survival were evaluated, and the underlying mechanisms were investigated. Sal B improved the survival area, reduced tissue edema, and increased the number of microvessels in skin flaps after 7 days, whereas an autophagy inhibitor (3-methyladenine) reversed the Sal B-induced increase in flap viability. In addition, Sal B stimulated angiogenesis, inhibited apoptosis, reduced oxidative stress, and upregulated autophagy in areas of ischemia. Moreover, the effects of Sal B on angiogenesis, apoptosis, and oxidative stress were reversed by autophagy inhibition. Overall, our findings suggest that Sal B has pro-angiogenesis, anti-apoptosis, and anti-oxidative stress effects by stimulating autophagy, which enhances the survival of random-pattern skin flaps

A Macromolecular Approach to Eradicate Multidrug Resistant Bacterial Infections while Mitigating Drug Resistance Onset

Polymyxins remain the last line treatment for multidrug-resistant (MDR) infections. As polymyxins resistance emerges, there is an urgent need to develop effective antimicrobial agents capable of mitigating MDR. Here, we report biodegradable guanidinium-functionalized polycarbonates with a distinctive mechanism that does not induce drug resistance. Unlike conventional antibiotics, repeated use of the polymers does not lead to drug resistance. Transcriptomic analysis of bacteria further supports development of resistance to antibiotics but not to the macromolecules after 30 treatments. Importantly, high in vivo treatment efficacy of the macromolecules is achieved in MDR A. baumannii-, E. coli-, K. pneumoniae-, methicillin-resistant S. aureus-, cecal ligation and puncture-induced polymicrobial peritonitis, and P. aeruginosa lung infection mouse models while remaining non-toxic (e.g., therapeutic index—ED50/LD50: 1473 for A. baumannii infection). These biodegradable synthetic macromolecules have been demonstrated to have broad spectrum in vivo antimicrobial activity, and have excellent potential as systemic antimicrobials against MDR infections

Boosting the performance of single-atom catalysts via external electric field polarization

Single-atom catalysts represent a unique catalytic system with high atomic utilization and tunable reaction pathway. Despite current successes in their optimization and tailoring through structural and synthetic innovations, there is a lack of dynamic modulation approach for the single-atom catalysis. Inspired by the electrostatic interaction within specific natural enzymes, here we show the performance of model single-atom catalysts anchored on two-dimensional atomic crystals can be systematically and efficiently tuned by oriented external electric fields. Superior electrocatalytic performance have been achieved in single-atom catalysts under electrostatic modulations. Theoretical investigations suggest a universal “onsite electrostatic polarization” mechanism, in which electrostatic fields significantly polarize charge distributions at the single-atom sites and alter the kinetics of the rate determining steps, leading to boosted reaction performances. Such field-induced on-site polarization offers a unique strategy for simulating the catalytic processes in natural enzyme systems with quantitative, precise and dynamic external electric fields

Non-phosgene synthesis of isocyanates based on CO2: Synthesis of methyl N-phenyl carbamate through coupling route with lead compound catalysts

The synthesis of methyl N-phenyl carbamate (MPC), the key intermediate for the non-phosgene synthesis of isocyanates based on CO2, was studied from the reaction of dimethyl carbonate and N,N'-diphenyl urea under pressure. A variety of solid catalysts were screened, which showed lead compounds such as PbO, PbO2, PbCO3, and 2PbCO(3)center dot Pb(OH)(2) had excellent catalytic activity. The characterization of XRD showed that the screened lead compound catalysts after reaction were changed into the same lead compound with the group -PbOH. With the increase of recycling times of the used lead compound catalysts, the selectivity of MPC and conversion of DPU were still about 99%. And the characterization of XRD and FRIR showed that new lead compound, which was produced with the increase of recycling times of the used lead compound catalysts, was also a lead compound with -PbOH. So the above results indicated that the real lead catalyst was the compound containing -PbOH. A possible reaction mechanism was discussed with the lead compound catalysts. (C) 2009 Elsevier B.V. All rights reserved