Proceedings of the 29th EG-ICE International Workshop on Intelligent Computing in Engineering

This publication is the Proceedings of the 29th EG-ICE International Workshop on Intelligent Computing in Engineering from July 6-8, 2022. The EG-ICE International Workshop on Intelligent Computing in Engineering brings together international experts working on the interface between advanced computing and modern engineering challenges. Many engineering tasks require open-world resolution of challenges such as supporting multi-actor collaboration, coping with approximate models, providing effective engineer-computer interaction, search in multi-dimensional solution spaces, accommodating uncertainty, including specialist domain knowledge, performing sensor-data interpretation and dealing with incomplete knowledge. While results from computer science provide much initial support for resolution, adaptation is unavoidable and most importantly, feedback from addressing engineering challenges drives fundamental computer-science research. Competence and knowledge transfer goes both ways. &nbsp

Proceedings of the 29th EG-ICE International Workshop on Intelligent Computing in Engineering

This publication is the Proceedings of the 29th EG-ICE International Workshop on Intelligent Computing in Engineering from July 6-8, 2022. The EG-ICE International Workshop on Intelligent Computing in Engineering brings together international experts working on the interface between advanced computing and modern engineering challenges. Many engineering tasks require open-world resolution of challenges such as supporting multi-actor collaboration, coping with approximate models, providing effective engineer-computer interaction, search in multi-dimensional solution spaces, accommodating uncertainty, including specialist domain knowledge, performing sensor-data interpretation and dealing with incomplete knowledge. While results from computer science provide much initial support for resolution, adaptation is unavoidable and most importantly, feedback from addressing engineering challenges drives fundamental computer-science research. Competence and knowledge transfer goes both ways. &nbsp

Nuclear expression of epidermal growth factor receptor is novel prognostic value in patients with ovarian cancer

[[abstract]]Epidermal growth factor receptor (EGFR) has been detected in the nucleus of cancer cells and primary tumors for decades. While localized in the nucleus, EGFR functions as a transcriptional regulator resulting in the activation of the cyclin D1 gene. Despite nuclear accumulation of EGFR is linked to increased DNA synthesis and proliferative potential, the pathological significance of nuclear EGFR, however, remains uninvestigated. Furthermore, expression of EGFR has not provided a consistent predictive value for survival of breast cancer patients. Here, we analyzed 130 breast carcinomas via immunohistochemical analyses for the levels of nuclear and non-nuclear EGFR. We found 37.7% of the cohort immunostained positively for nuclear EGFR and 6.9% with high levels of expression. Importantly, Kaplan-Meier survival analysis and log-rank test revealed a significant inverse correlation between high nuclear EGFR and overall survival (P = 0.009). Expression of nuclear EGFR correlated positively with increased levels of cyclin D1 and Ki-67, both are indicators for cell proliferation. In contrast, expression of non-nuclear EGFR did not significantly correlate with those of cyclin D1 and Ki-67 or the overall survival rate. In addition, we analyzed 37 oral squamous carcinomas for EGFR expression and found 24.3% of the cases to contain moderate/high levels of nuclear EGFR. Taken together, our findings indicate pathological significance of nuclear EGFR and may have important clinical implication

Experimental Study of Frame-Supported Shear Wall Structure of High-Rise Buildings with Transfer Slab in Metro Depot

Taking the frame-supported shear wall structure of a 102.1 m high metro depot as the test object, the structure has obvious vertical irregularity, and a quasi-static test was carried out on the structural model with the scale of 1/5. The damage development and strain of the structure were observed by applying displacement loads under different seismic actions, and the experimental phenomena and measured data were analyzed. The results show that the safety performance of the structure meets the seismic requirements of the MCE (Maximum considered earthquake) condition. Under the action of load, a reasonable damage mechanism is formed in which the components above the transfer story crack first and those below the transfer story crack later, which is in line with the design concept of “the performance objective of the bottom frame structure is higher than that of the upper shear wall structure”. The transfer plate is mainly subjected to shear deformation, the possible shear failure of the transfer plate should be avoided by reasonable design. Due to the large height difference between the first floor and the second floor, the structure may be adversely affected, so it is necessary to make the yielding floor appear in the bottom strengthening part above the transfer story. Under the SLE (Service level earthquake) and DBE (Design based earthquake) conditions, the bottom frame of the structure is mainly subjected to elastic deformation. Under the MCE (Maximum considered earthquake) condition, the bottom frame of the structure causes a lot of damage, increases energy consumption and decreases stiffness, which further proves that “the performance goal of the bottom frame structure is higher than that of the upper shear wall structure”

Experimental Study of Frame-Supported Shear Wall Structure of High-Rise Buildings with Transfer Slab in Metro Depot

Taking the frame-supported shear wall structure of a 102.1 m high metro depot as the test object, the structure has obvious vertical irregularity, and a quasi-static test was carried out on the structural model with the scale of 1/5. The damage development and strain of the structure were observed by applying displacement loads under different seismic actions, and the experimental phenomena and measured data were analyzed. The results show that the safety performance of the structure meets the seismic requirements of the MCE (Maximum considered earthquake) condition. Under the action of load, a reasonable damage mechanism is formed in which the components above the transfer story crack first and those below the transfer story crack later, which is in line with the design concept of “the performance objective of the bottom frame structure is higher than that of the upper shear wall structure”. The transfer plate is mainly subjected to shear deformation, the possible shear failure of the transfer plate should be avoided by reasonable design. Due to the large height difference between the first floor and the second floor, the structure may be adversely affected, so it is necessary to make the yielding floor appear in the bottom strengthening part above the transfer story. Under the SLE (Service level earthquake) and DBE (Design based earthquake) conditions, the bottom frame of the structure is mainly subjected to elastic deformation. Under the MCE (Maximum considered earthquake) condition, the bottom frame of the structure causes a lot of damage, increases energy consumption and decreases stiffness, which further proves that “the performance goal of the bottom frame structure is higher than that of the upper shear wall structure”

SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization

Steroid receptor coactivator 3 (SRC-3) is an oncogenic nuclear receptor coactivator that plays a significant role in drug resistance. Using a lentiviral cDNA library rescue screening approach, we identified a SRC-3 downstream gene—TRAF4 (tumor necrosis factor [TNF] receptor associated-factor 4)—that functions in cell resistance to cytotoxic stress. TRAF4 expression is positively correlated with SRC-3 expression in human breast cancers. Similar to that observed for SRC-3 overexpression, breast cancer cells overexpressing TRAF4 are more resistant to stress-induced death. Here, we further dissected the underlying molecular mechanism for SRC-3 and TRAF4-mediated resistance to cytotoxic agents. We observed that SRC-3 expression is inversely correlated with the expression of p53-regulated proapoptotic genes in breast cancers and further found that SRC-3 and TRAF4 overexpression diminished cytotoxic stress-induced up-regulation of the tumor suppressor p53 protein. To determine the mechanism, we showed that the TRAF domain of TRAF4 bound to the N-terminal TRAF-like region of the deubiquitinase HAUSP (herpesvirus-associated ubiquitin-specific protease; also named USP7) and blocked the access of p53 to the same region of HAUSP. This TRAF4-mediated inhibition of HAUSP then led to the loss of p53 deubiquitination and its stabilization in response to cellular stress. Consistent with this cellular function, we also found that TRAF4 overexpression in breast cancer patients was associated significantly with poor prognosis. Because of SRC-3's ability to abrogate p53 function, our results suggest that SRC-3 overexpression may be especially important in tumors in which p53 is not mutated