Two-Loop Diagrammatics in a Self-Dual Background

Diagrammatic rules are developed for simplifying two-loop QED diagrams with propagators in a constant self-dual background field. This diagrammatic analysis, using dimensional regularization, is used to explain how the fully renormalized two-loop Euler-Heisenberg effective Lagrangian for QED in a self-dual background field is naturally expressed in terms of one-loop diagrams. The connection between the two-loop and one-loop vacuum diagrams in a background field parallels a corresponding connection for free vacuum diagrams, without a background field, which can be derived by simple algebraic manipulations. It also mirrors similar behavior recently found for two-loop amplitudes in N=4 SUSY Yang-Mills theory.Comment: 16 pp, Latex, Axodra

Spallation reactions. A successful interplay between modeling and applications

The spallation reactions are a type of nuclear reaction which occur in space by interaction of the cosmic rays with interstellar bodies. The first spallation reactions induced with an accelerator took place in 1947 at the Berkeley cyclotron (University of California) with 200 MeV deuterons and 400 MeV alpha beams. They highlighted the multiple emission of neutrons and charged particles and the production of a large number of residual nuclei far different from the target nuclei. The same year R. Serber describes the reaction in two steps: a first and fast one with high-energy particle emission leading to an excited remnant nucleus, and a second one, much slower, the de-excitation of the remnant. In 2010 IAEA organized a worskhop to present the results of the most widely used spallation codes within a benchmark of spallation models. If one of the goals was to understand the deficiencies, if any, in each code, one remarkable outcome points out the overall high-quality level of some models and so the great improvements achieved since Serber. Particle transport codes can then rely on such spallation models to treat the reactions between a light particle and an atomic nucleus with energies spanning from few tens of MeV up to some GeV. An overview of the spallation reactions modeling is presented in order to point out the incomparable contribution of models based on basic physics to numerous applications where such reactions occur. Validations or benchmarks, which are necessary steps in the improvement process, are also addressed, as well as the potential future domains of development. Spallation reactions modeling is a representative case of continuous studies aiming at understanding a reaction mechanism and which end up in a powerful tool.Comment: 59 pages, 54 figures, Revie

Scientific Prospects for Hard X-ray Polarimetry

X-ray polarimetry promises to give qualitatively new information about high-energy sources. Examples of interesting source classes are binary black hole systems, rotation and accretion powered neutron stars, Microquasars, Active Galactic Nuclei and Gamma-Ray Bursts. Furthermore, X-ray polarimetry affords the possibility for testing fundamental physics, e.g. to observe signatures of light bending in the strong gravitational field of a black hole, to detect third order Quantum Electrodynamic effects in the magnetosphere of Magnetars, and to perform sensitive tests of Lorentz Invariance. In this paper we discuss scientific drivers of hard (>10 keV) X-ray polarimetry emphasizing how observations in the hard band can complement observations at lower energies (0.1 - 10 keV). Subsequently, we describe four different technical realizations of hard X-ray polarimeters suitable for small to medium sized space borne missions, and study their performance in the signal-dominated case based on Monte Carlo simulations. We end with confronting the instrument requirements for accomplishing the science goals with the capabilities of the four polarimeters.Comment: Accepted for publication in Astroparticle Physic

Supplementary Material for: Cross-Sectional Association between Polyfluoroalkyl Chemicals and Cognitive Limitation in the National Health and Nutrition Examination Survey

<b><i>Background/Aims:</i></b> Our limited understanding of how polyfluoroalkyl chemicals (PFCs) may impact on human health suggests the potential for a protective impact on brain health. This study was designed to explore the association between PFCs and cognitive ability in older adults. <b><i>Methods:</i></b> We assessed the association between four PFCs, perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorononanoic acid (PFNA) and perfluorohexane sulfonic acid (PFHxS), and self-reported limitation due to difficulty remembering or periods of confusion using data from participants aged 60–85 years from the 1999–2000 and 2003–2008 National Health and Nutrition Examination Surveys. We also considered whether diabetic status or diabetic medication use modifies this association in light of in vitro evidence that PFCs may act on the same receptors as some diabetic medications. <b><i>Results:</i></b> In multivariable adjusted models, point estimates suggest a protective association between PFCs and self-reported cognitive limitation (odds ratio, OR; 95% confidence interval, CI) for a doubling in PFC concentration: PFOS (OR, 0.90; 95% CI, 0.78, 1.03), PFOA (OR, 0.92; 95% CI, 0.78, 1.09), PFNA (OR, 0.91; 95% CI, 0.79, 1.04) and PFHxS (OR, 0.93; 95% CI, 0.82, 1.06). The protective association was concentrated in diabetics, with strong, significant protective associations in nonmedicated diabetics. <b><i>Conclusions:</i></b> This cross-sectional study suggests that there may be a protective association between exposure to PFCs and cognition in older adults, particularly diabetics

Medical Conditions in Former Professional American-Style Football Players Are Associated With Self-Reported Clinical Features of Traumatic Encephalopathy Syndrome.

Consensus criteria for traumatic encephalopathy syndrome (TES) specify that at least one core clinical feature of cognitive impairment (CI; e.g., difficulties with memory, executive function) or neurobehavioral dysregulation (ND; e.g., explosiveness, rage, and mood lability) be present and not fully accounted for by other health disorders. Associations between self-reported symptoms that mirror the core clinical features of TES-and how they may be related to concomitant medical conditions-remain unclear. The purpose of this study was to evaluate the association of medical conditions and football exposures with TES clinical features (CI &lt;sup&gt;+/-&lt;/sup&gt; , ND &lt;sup&gt;+/-&lt;/sup&gt; ) in 1741 former professional American-style football (ASF) players (age, 57.7 ± 13.9 years; professional seasons, 6.6 ± 3.9 years). Demographics (age, race/ethnicity, current body mass index, age of first football exposure, use of performance-enhancing drugs, position played, and past concussion symptoms), self-reported medical conditions (anxiety, depression, attention-deficit hyperactivity disorder [ADHD], sleep apnea, headache, stroke, hypertension, heart disease, high cholesterol, erectile dysfunction, and low testosterone) were collected. Of 1741 participants, 7.4% were CI &lt;sup&gt;+&lt;/sup&gt; and/or ND &lt;sup&gt;+&lt;/sup&gt; (n = 129). Participants who were CI &lt;sup&gt;+&lt;/sup&gt; or ND &lt;sup&gt;+&lt;/sup&gt; were more likely to report one or more coexisting medical conditions than participants who did not report CI or ND (odds ratio [OR] = 2.04; 95% confidence interval: 1.25-3.47; p = 0.003). Separate general linear models for each medical condition that adjusted for demographics and football-related factors identified significant associations between ADHD, diabetes, erectile dysfunction, headaches, sleep apnea, anxiety, and low testosterone and CI &lt;sup&gt;+&lt;/sup&gt; and/or ND &lt;sup&gt;+&lt;/sup&gt; (ORs = 1.8-6.0). Chi-square automatic interaction detection (CHAID) multi-variable decision tree models that incorporated medical conditions and football exposures accurately differentiated former players meeting either CI or ND clinical criteria from those meeting none (accuracy = 91.2-96.6%). CHAID identified combinations of depression, headache, sleep apnea, ADHD, and upper quartiles of concussion symptom history as most predictive of CI &lt;sup&gt;+&lt;/sup&gt; and/or ND &lt;sup&gt;+&lt;/sup&gt; status. CI &lt;sup&gt;+&lt;/sup&gt; and/or ND &lt;sup&gt;+&lt;/sup&gt; players were more likely to report medical conditions known to cause cognitive symptoms. Concussion exposure and medical conditions significantly increased the likelihood that a former ASF player would demonstrate cognitive or neurobehavioral dysfunction. Clinicians engaged with this population should consider whether treatable coexisting condition(s) could account for some portion of the clinical picture associated with TES presentation

Association Between Concussion Burden During Professional American-Style Football and Postcareer Hypertension.

Previous work has demonstrated an association between American-style football (ASF) and the development of hypertension among collegiate athletes.1 In addition, hypertension prevalence has been shown to be higher among active professional ASF athletes compared with similarly aged members of the general population.2 Whereas causal factors including deliberate weight gain, repetitive isometric strength training, sleep apnea, and nonsteroidal anti-inflammatory drug use have been suggested, definitive mechanisms remain incompletely understood. Recent studies in general populations have shown associations between brain injury and subsequent hypertension.3 Given that ASF players are at particular risk for recurrent head injury, the relationship between concussion history and later life hypertension deserves focused exploration

NMDA receptors are essential for the acquisition, but not expression, of conditional fear and associative spike firing in the lateral amygdala

We examined the contribution of N -methyl-D-aspartate (NMDA) receptors (NMDARs) to the acquisition and expression of amygdaloid plasticity and Pavlovian fear conditioning using single-unit recording techniques in behaving rats. We demonstrate that NMDARs are essential for the acquisition of both behavioral and neuronal correlates of conditional fear, but play a comparatively limited role in their expression. Administration of the competitive NMDAR antagonist ±-3-(2-carboxypiperazin-4-yl) propyl-1-phosphonic acid (CPP) prior to auditory fear conditioning completely abolished the acquisition of conditional freezing and conditional single-unit activity in the lateral amygdala (LA). In contrast, CPP given prior to extinction testing did not affect the expression of conditional single-unit activity in LA, despite producing deficits in conditional freezing. Administration of CPP also blocked the induction of long-term potentiation in the amygdala. Together, these data suggest that NMDARs are essential for the acquisition of conditioning-related plasticity in the amygdala, and that NMDARs are more critical for regulating synaptic plasticity and learning than routine synaptic transmission in the circuitry supporting fear conditioning.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/71768/1/j.1460-9568.2004.03513.x.pd