Primer Festival de Nuevo Teatro en Washington: Trayectoria y análisis

Primer Festival de Nuevo Teatro en Washington: Trayectoria y análisi

Utopian Projects and Crises of Theory: Describing the Elephant

Utopian Projects and Crises of Theory: Describing the Elephan

Cuba's Teatro Nuevo: First National Festival

Cuba's Teatro Nuevo: First National Festiva

Deterring discrimination with data

Discrimination on grounds of race, sex, and handicap persists in many local school districts in spite of nearly twenty years of sustained attention from federal policymakers. Because litigation proceeds slowly and expensively, and because administrative attacks on discrimination have been stymied by political controversy, additional policy strategies merit careful consideration. We studied the operation of one such strategy in nine local districts: the mandatory collection of data concerning civil rights matters in schools. Data collection and reporting shaped local compliance with civil rights laws in four ways: by threatening local officials with future penalties, by providing political ammunition to constituencies that care about civil rights, by allowing local districts to learn about their own performance, and by framing school practices in ways that heighten awareness about equity. In this policy setting, data collection has advantages and disadvantages that complement those of other enforcement strategies. In this and other policy settings, data collection has power to elicit compliance even in the absence of conventional enforcement.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45444/1/11077_2004_Article_BF00229728.pd

Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis.

How pathogenic cluster of differentiation 4 (CD4) T cells in rheumatoid arthritis (RA) develop remains poorly understood. We used Nur77-a marker of T cell antigen receptor (TCR) signaling-to identify antigen-activated CD4 T cells in the SKG mouse model of autoimmune arthritis and in patients with RA. Using a fluorescent reporter of Nur77 expression in SKG mice, we found that higher levels of Nur77-eGFP in SKG CD4 T cells marked their autoreactivity, arthritogenic potential, and ability to more readily differentiate into interleukin-17 (IL-17)-producing cells. The T cells with increased autoreactivity, nonetheless had diminished ex vivo inducible TCR signaling, perhaps reflective of adaptive inhibitory mechanisms induced by chronic autoantigen exposure in vivo. The enhanced autoreactivity was associated with up-regulation of IL-6 cytokine signaling machinery, which might be attributable, in part, to a reduced amount of expression of suppressor of cytokine signaling 3 (SOCS3)-a key negative regulator of IL-6 signaling. As a result, the more autoreactive GFPhi CD4 T cells from SKGNur mice were hyperresponsive to IL-6 receptor signaling. Consistent with findings from SKGNur mice, SOCS3 expression was similarly down-regulated in RA synovium. This suggests that despite impaired TCR signaling, autoreactive T cells exposed to chronic antigen stimulation exhibit heightened sensitivity to IL-6, which contributes to the arthritogenicity in SKG mice, and perhaps in patients with RA

C and N Abundances in Stars At the Base of the Red Giant Branch in M5

We present an analysis of a large sample of moderate resolution Keck LRIS spectra of subgiant (V \sim 17.2) and fainter stars in the Galactic globular cluster M5 (NGC 5904) with the goal of deriving C and N abundances. Star-to-star stochastic variations with significant range in both [C/Fe] and [N/Fe] are found at all luminosities extending to the bottom of the RGB at M_V \sim +3. Similar variations in CH appear to be present in the main sequence turnoff spectra. There is no sign of a change in the behavior of C and N with evolutionary stage over the full range in luminosity of the RGB and SGB. The C and N abundances appear strongly anti-correlated, as would be expected from the CN-cycle processing of stellar material. Yet the present stars are considerably fainter than the RGB bump, the point at which deep mixing is believed to set in. On this basis, while the observed abundance pattern is consistent with proton capture nucleosynthesis, we infer that the site of the reactions is likely not within the present sample, but rather in a population of more massive (2 -- 5 M(Sun)) now defunct stars. The range of variation of the N abundances is very large and the sum of C+N increases as C decreases. To reproduce this requires the incorporation not only of CN but also of ON-processed material. Furthermore, the existence of this correlation is quite difficult to reproduce with an external mechanism such as ``pollution'' with material processed in a more massive AGB star, which mechanism is fundamentally stochastic in nature. We therefore suggest that although the internal mixing hypothesis has serious flaws,new theoretical insights are needed and it should not be ruled out yet. (abridged)Comment: Slightly updated version to conform to that accepted by the A

High Levels of Persistent Problem Drinking in Women at High Risk for HIV in Kampala, Uganda: A Prospective Cohort Study.

The aim of this study was to describe the epidemiology of problem drinking in a cohort of women at high-risk of HIV in Kampala, Uganda. Overall, 1027 women at high risk of HIV infection were followed from 2008 to 2013. The CAGE and AUDIT questionnaires were used to identify problem drinkers in the cohort. Interviewer-administered questionnaires were used to ascertain socio-demographic and behavioural factors. Blood and genital samples were tested for HIV and other sexually transmitted infections. At enrollment, most women (71%) reported using alcohol at least weekly and about a third reported having drunk alcohol daily for at least 2 weeks during the past 3 months. Over half (56%) were problem drinkers by CAGE at enrollment, and this was independently associated with vulnerability (being divorced/separated/widowed, less education, recruiting clients at bars/clubs, and forced sex at first sexual experience). Factors associated with problem drinking during follow-up included younger age, meeting clients in bars/clubs, number of clients, using drugs and HSV-2 infection. HIV prevalence was associated with drinking at enrollment, but not during follow-up. This longitudinal study found high levels of persistent problem drinking. Further research is needed to adapt and implement alcohol-focused interventions in vulnerable key populations in sub-Saharan Africa

Abundances in Stars from the Red Giant Branch Tip to Near the Main Sequence Turn Off in M71: III. Abundance Ratios

We present abundance ratios for 23 elements with respect to Fe in a sample of stars with a wide range in luminosity, from luminous giants to stars near the turnoff, in the globular cluster M71. The analyzed spectra, obtained with HIRES at the Keck Observatory, are of high dispersion (R=35,000). We find that the neutron capture, the iron peak and the alpha-element abundance ratios show no trend with Teff, and low scatter around the mean between the top of the RGB and near the main sequence turnoff. The alpha-elements Mg, Ca, Si and Ti are overabundant relative to Fe. The anti-correlation between O and Na abundances, observed in other metal poor globular clusters, is detected in our sample and extends to the main sequence. A statistically significant correlation between Al and Na abundances is observed among the M71 stars in our sample, extending to Mv = +1.8, fainter than the luminosity of the RGB bump in M5. Lithium is varying, as expected, and Zr may be varying from star to star as well. M71 appears to have abundance ratios very similar to M5 whose bright giants were studied by Ivans et al. (2001), but seems to have a smaller amplitude of star-to-star variations at a given luminosity, as might be expected from its higher metallicity. The results of our abundance analysis of 25 stars in M71 provide sufficient evidence of abundance variations at unexpectedly low luminosities to rule out the mixing scenario. Either alone or, even more powerfully, combined with other recent studies of C and N abundances in M71 stars, the existence of such abundance variations cannot be reproduced within the context of our current understanding of stellar evolution.Comment: AJ, in press (June 2002), 18 figure

Association between Mycoplasma genitalium infection and HIV acquisition among female sex workers in Uganda: evidence from a nested case-control study.

OBJECTIVES: Cross-sectional studies have shown a strong association between Mycoplasma genitalium and HIV infections. We previously reported that in a cohort of female sex workers in Uganda, M genitalium infection at baseline was associated with HIV seroconversion. Here we examine the temporal association between the M genitalium infection status shortly before HIV seroconversion and HIV acquisition. METHODS: A nested case-control study was conducted within a cohort of women at high risk for HIV in Kampala. Cases were those of women acquiring HIV within 2 years of enrolment. For each of the 42 cases, 3 controls were selected from women HIV negative at the visit when the corresponding case first tested HIV seropositive. The association between HIV acquisition and M genitalium infection immediately prior to HIV testing was analysed using conditional logistic regression. RESULTS: There was weak evidence of an association between M genitalium infection and HIV acquisition overall (crude OR=1.57; 95% CI 0.67 to 3.72, aOR=2.28: 95% CI 0.81 to 6.47). However, time of M genitalium testing affected the association (p value for effect-modification=0.004). For 29 case-control sets with endocervical samples tested 3 months prior to the first HIV-positive result, M genitalium infection increased the risk of HIV acquisition (crude OR=3.09; 95% CI 1.06 to 9.05, aOR=7.19; 95% CI 1.68 to 30.77), whereas there was little evidence of an association among the 13 case-control sets with samples tested at an earlier visit (crude OR=0.30: 95% CI 0.04 to 2.51; aOR=0.34; 95% CI 0.02 to 5.94). CONCLUSIONS: Our study showed evidence of a temporal relationship between M genitalium infection and HIV acquisition that suggests that M genitalium infection may be a co-factor in the acquisition of HIV infection

Bacterial vaginosis among women at high risk for HIV in Uganda: high rate of recurrent diagnosis despite treatment.

OBJECTIVES: Bacterial vaginosis (BV) is associated with increased risk for sexually transmitted infections (STIs) and HIV acquisition. This study describes the epidemiology of BV in a cohort of women at high risk for STI/HIV in Uganda over 2 years of follow-up between 2008-2011. METHODS: 1027 sex workers or bar workers were enrolled and asked to attend 3-monthly follow-up visits. Factors associated with prevalent BV were analysed using multivariate random-effects logistic regression. The effect of treatment on subsequent episodes of BV was evaluated with survival analysis. RESULTS: Prevalences of BV and HIV at enrolment were 56% (573/1027) and 37% (382/1027), respectively. Overall, 905 (88%) women tested positive for BV at least once in the study, over a median of four visits. Younger age, a higher number of previous sexual partners and current alcohol use were independently associated with prevalent BV. BV was associated with STIs, including HIV. Hormonal contraception and condom use were protective against BV. Among 853 treated BV cases, 72% tested positive again within 3 months. There was no difference in time to subsequent BV diagnosis between treated and untreated women. CONCLUSIONS: BV was highly prevalent and persistent in this cohort despite treatment. More effective treatment strategies are urgently needed