Singing the critical life: folk, place, and the palimpsest of rhythms in the beat of the city

Purpose – The purpose of this paper is to provide an ethnographic account of a folk music venue from the perspective of a participant observer. Design/methodology/approach – The research is based on a classic thick description, describing the central participants in a performance and the operation of spacing and timing processes, thus significantly creating private ownership of a public space. Findings – There are collective proceses of spacing and timing that are informal but normative framing what superficially appears to constitute random or unstructured activities. The musical knowledge and performance competence drive these processes rather than externally visible considerations of authenticity. Research limitations/implications – This paper is a single-venue descriptive research. Originality/value – This paper adds to the relatively few small-scale ethnographies of urban music venues. Keywords Regulation, Authenticity, Auto-ethnography, Music performance, Folk, Timing Paper type Research pape

Navigating wasta in business practices in Lebanon

Faced with severe social, political, and economic challenges, Lebanon is described as a weak state. Argued to be a key factor weakening the formal institutions there, is the prevalent practice of wasta. This article seeks to answer two questions: (1) Why is wasta prevalent in a business environment characterised by weak formal institutions, such as Lebanon? (2) How can managers navigate the use of wasta in the Lebanese business context where it prevails, avoiding its negative outcomes while utilizing its positive outcomes? Fourteen semi‐structured interviews were conducted of managers from the Lebanese industrial sector. The findings highlight that wasta is used due to the networked nature of Lebanese society, economic hardship, widespread corruption and to maintain power. It was found that wasta could be beneficial in securing jobs, removing red tape, and gaining employment for humanitarian reasons. Finally, the negative outcomes of using wasta were found to include the employment of unqualified individuals, a reduction of organizations' productivity and a further weakening of formal institutions

Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes

Serum magnesium and calcium levels in relation to ischemic stroke : Mendelian randomization study

ObjectiveTo determine whether serum magnesium and calcium concentrations are causally associated with ischemic stroke or any of its subtypes using the mendelian randomization approach.MethodsAnalyses were conducted using summary statistics data for 13 single-nucleotide polymorphisms robustly associated with serum magnesium (n = 6) or serum calcium (n = 7) concentrations. The corresponding data for ischemic stroke were obtained from the MEGASTROKE consortium (34,217 cases and 404,630 noncases).ResultsIn standard mendelian randomization analysis, the odds ratios for each 0.1 mmol/L (about 1 SD) increase in genetically predicted serum magnesium concentrations were 0.78 (95% confidence interval [CI] 0.69-0.89; p = 1.3 7 10-4) for all ischemic stroke, 0.63 (95% CI 0.50-0.80; p = 1.6 7 10-4) for cardioembolic stroke, and 0.60 (95% CI 0.44-0.82; p = 0.001) for large artery stroke; there was no association with small vessel stroke (odds ratio 0.90, 95% CI 0.67-1.20; p = 0.46). Only the association with cardioembolic stroke was robust in sensitivity analyses. There was no association of genetically predicted serum calcium concentrations with all ischemic stroke (per 0.5 mg/dL [about 1 SD] increase in serum calcium: odds ratio 1.03, 95% CI 0.88-1.21) or with any subtype.ConclusionsThis study found that genetically higher serum magnesium concentrations are associated with a reduced risk of cardioembolic stroke but found no significant association of genetically higher serum calcium concentrations with any ischemic stroke subtype

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol- increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels

A device to attract the money? Or an invitation to partnership?

This chapter questions the basis of the general perception of universities that like most educational institutions they can be trusted, suggesting that this comes about because they are seen to be guardians of a search for the truth. But a brief case history indicates that truth is indeed a contested terrain and that universities may be tempted to conceive of themselves as permitting them also to be generic arbiters of the truth as embodied in the knowledge they choose to impart and research. There is a penumbra of obligation and thus sequences of events and actions that fall within the arena of ethical judgement and it is the realm of these with which this chapter is concerned. There are opportunities for conflict with those institutions whose claimed truths are embodied in experience and practice. Difficulties in understanding what has gone wrong make it difficult to enforce relations based on contract that are not understood in the same sense by the would-be partners