An overview of reference user services during the ATDRSS (Advanced Tracking and Data Relay Satellite System) era

The Tracking and Data Relay Satellite System (TDRSS) is an integral part of the overall NASA Space Network (SN) that will continue to evolve into the 1990's. Projections for the first decade of the 21st century indicate the need for an SN evolution that must accommodate growth int he LEO user population and must further support the introduction of new/improved user services. A central ingredient of this evolution is an Advanced TDRSS (ATDRSS) follow-on to the current TDRSS that must initiate operations by the late 1990's in a manner that permits an orderly transition from the TDRSS to the ATDRSS era. An SN/ATDRSS architectural and operational concept that will satisfy the above goals is being developed. To this date, an SN/ATDRSS baseline concept was established that provides users with an end-to-end data transport (ENDAT) service. An expanded description of the baseline ENDAT concept, from the user perspective, is provided with special emphasis on the TDRSS/ATDRSS evolution. A high-level description of the end-to-end system that identifies the role of ATDRSS is presented; also included is a description of the baseline ATDRSS architecture and its relationship with the TDRSS 1996 baseline. Other key features of the ENDAT service are then expanded upon, including the multiple grades of service, and the RF telecommunications/tracking services to be available. The ATDRSS service options are described

Evolution of NASA's Near-Earth Tracking and Data Relay Satellite System (TDRSS)

NASA's Tracking and Data Relay Satellite System (TDRSS) is now in its 23rd year of operations and its spacecraft fleet includes three second-generation spacecraft launched since the year 2000; a figure illustrates the first generation TDRSS spacecraft. During this time frame the TDRSS has provided communications relay support to a broad range of missions, with emphasis on low-earth-orbiting (LEO) spacecraft that include unmanned science spacecraft (e.g., Hubble Space Telescope), and human spaceflight (Space Shuttle and Space Station). Furthermore, the TDRSS has consistently demonstrated its uniqueness and adaptability in several ways. First, its S- and K-band services, combined with its multi-band/steerable single-access (SA) antennas and ground-based configuration flexibility, have permitted the mission set to expand to unique users such as scientific balloons and launch vehicles. Second, the bent-pipe nature of the system has enabled the introduction of new/improved services via technology insertion and upgrades at each of the ground terminals; a specific example here is the Demand Access Service (DAS), which, for example, is currently providing science-alert support to NASA science missions Third, the bent-pipe nature of the system, combined with the flexible ground-terminal signal processing architecture has permitted the demonstration/vaIidation of new techniques/services/technologies via a real satellite channel; over the past 10+ years these have, for example, included demonstrations/evaluations of emerging modulation/coding techniques. Given NASA's emerging Exploration plans, with missions beginning later this decade and expanding for decades to come, NASA is currently planning the development of a seamless, NASA-wide architecture that must accommodate missions from near-earth to deep space. Near-earth elements include Ground-Network (GN) and Near-Earth Relay (NER) components and both must efficiently and seamlessly support missions that encompass: earth orbit, including dedicated science missions and lunar support/cargo vehicles; earth/moon transit; lunar in-situ operations; and other missions within approximately 2 million km of earth (e.g., at the sun/earth libration points). Given that the NER is an evolution of TDRSS, one element of this NASA-wide architecture development activity is a trade study of future NER architecture candidates. The present paper focuses on trade study aspects associated with the NER, highlights study elements, and provides representative interim results

Demand access communications for TDRSS users

The Tracking and Data Relay Satellite System (TDRSS) has long been used to provide reliable low and high-data rate relay services between user spacecraft in Earth orbit and the ground. To date, these TDRSS services have been implemented via prior scheduling based upon estimates of user needs and mission event timelines. While this approach may be necessary for large users that require greater amounts of TDRSS resources, TDRSS can potentially offer the planned community of smaller science missions (e.g., the small explorer missions), and other emerging users, the unique opportunity for services on demand. In particular, innovative application of the existing TDRSS Multiple Access (MA) subsystem, with its phased array antenna, could be used to implement true demand access services without modification to either the TDRSS satellites or the user transponder, thereby introducing operational and performance benefits to both the user community and the Space Network. In this paper, candidate implementations of demand access service via the TDRSS MA subsystem are examined in detail. Both forward and return link services are addressed and a combination of qualitative and quantitative assessments are provided. The paper also identifies further areas for investigation in this ongoing activity that is being conducted by GSFC/Code 531 under the NASA Code O Advanced Systems Program

Protein Modification by Dicarbonyl Molecular Species in Neurodegenerative Diseases

Neurodegeneration results from abnormalities in cerebral metabolism and energy balance within neurons, astrocytes, microglia, or microvascular endothelial cells of the blood-brain barrier. In Alzheimer's disease, β-amyloid is considered the primary contributor to neuropathology and neurodegeneration. It now is believed that certain systemic diseases, such as diabetes mellitus, can contribute to neurodegeneration through the effects of chronic hyperglycemia/insulin resistance resulting in protein glycation, oxidative stress and inflammation within susceptible brain regions. Here, we present an overview of research focusing on the role of protein glycation, oxidative stress, and inflammation in the neurodegenerative process. Of special interest in this paper is the effect of methylglyoxal (MGO), a cytotoxic byproduct of glucose metabolism, elevated in neurodegenerative disease, and diabetes mellitus, on cerebral protein function and oxidative stress. How MGO interacts with amino acid residues within β-amyloid, and small peptides within the brain, is also discussed in terms of the affect on protein function

Undergraduate students\u27 self-reported use of mathematics textbooks

Textbooks play an important role in undergraduate mathematics courses and have the potential to impact student learning. However, there have been few studies that describe students\u27 textbook use in detail. In this study, 1156 undergraduate students in introductory mathematics classes were surveyed, and asked to describe how they used their textbook. The results indicate that students tend to use examples, instead of the expository text, to build their mathematical understanding, which instructors may view as problematic. This way of using the textbook may be the result of the textbook structure itself, as well as students\u27 beliefs about reading and the nature of mathematics. Although many instructors may not clearly convey how they want their students to use the textbook, students do report using it more productively when they believe they are asked to do so. This suggests that instructors should carefully choose text materials to promote mathematical reasoning, and actively encourage their students to read the text in a way that supports the development of this reasoning

Ramping Up Antimicrobial Peptides Against Severe Acute Respiratory Syndrome Coronavirus-2

Human-derived antimicrobial peptides (AMPs), such as defensins and cathelicidin LL-37, are members of the innate immune system and play a crucial role in early pulmonary defense against viruses. These AMPs achieve viral inhibition through a variety of mechanisms including, but not limited to, direct binding to virions, binding to and modulating host cell-surface receptors, blocking viral replication, and aggregation of viral particles and indirectly by functioning as chemokines to enhance or curb adaptive immune responses. Given the fact that we are in a pandemic of unprecedented severity and the urgent need for therapeutic options to combat severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), naturally expressed AMPs and their derivatives have the potential to combat coronavirus disease 2019 (COVID-19) and impede viral infectivity in various ways. Provided the fact that development of effective treatments is an urgent public health priority, AMPs and their derivatives are being explored as potential prophylactic and therapeutic candidates. Additionally, cell-based platforms such as human mesenchymal stem cell (hMSC) therapy are showing success in saving the lives of severely ill patients infected with SARS-CoV-2. This could be partially due to AMPs released from hMSCs that also act as immunological rheostats to modulate the host inflammatory response. This review highlights the utilization of AMPs in strategies that could be implemented as novel therapeutics, either alone or in combination with other platforms, to treat CoV-2–infected individuals

Quartet S Wave Neutron Deuteron Scattering in Effective Field Theory

The real and imaginary part of the quartet S wave phase shift in nd scattering (^4 S_{3/2}) for centre-of-mass momenta of up to 300 MeV (E_cm \approx 70 MeV) is presented in effective field theory, using both perturbative pions and a theory in which pions are integrated out. As available, the calculation agrees with both experimental data and potential model calculations, but extends to a higher, so far untested momentum r\'egime above the deuteron breakup point. A Lagrangean more feasible for numerical computations is derived.Comment: 27 pages LaTeX2e with 11 figures, uses packages includegraphicx (6 .eps files), color and feynmp (necessary Metapost files included). Corrections in bibliography and NNLO results added above breaku

Policy Considerations & Industry Perspectives on 3D Printing

The Cardozo Arts and Entertainment Law Journal hosted its Spring Symposium on Monday, February 2nd, 2015. The heavy precipitation and frigid temperatures did not stop practitioners, scholars and students alike from coming together in impressive numbers to engage in a discussion about the intellectual property issues surrounding 3D printing