Establishing Scientific Mechanisms to Maintain Security of the Core Socialist Values

Since the public’s wide cognition and profound recognition of the core socialist values serve as the primary prerequisite for safeguarding the values system, it is quite necessary to explore the rules of cognition and recognition as well as establish sound and scientific mechanisms. The establishment of a scientific interpretation mechanism, a reasonable publicity mechanism, an effective education mechanism and an overall coordination mechanism forms the prerequisite and essence for and the guarantee of the public’s wide cognition and profound recognition of the core socialist values. In this way, the core socialist values can be translated from values objective, orientation and criterion to collective awareness, the guide and objective that the public voluntarily pursue, the firm belief and behavioral guideline within the public and in turn moral practice and conscious action

A snoRNA modulates mRNA 3' end processing and regulates the expression of a subset of mRNAs.

mRNA 3' end processing is an essential step in gene expression. It is well established that canonical eukaryotic pre-mRNA 3' processing is carried out within a macromolecular machinery consisting of dozens of trans-acting proteins. However, it is unknown whether RNAs play any role in this process. Unexpectedly, we found that a subset of small nucleolar RNAs (snoRNAs) are associated with the mammalian mRNA 3' processing complex. These snoRNAs primarily interact with Fip1, a component of cleavage and polyadenylation specificity factor (CPSF). We have functionally characterized one of these snoRNAs and our results demonstrated that the U/A-rich SNORD50A inhibits mRNA 3' processing by blocking the Fip1-poly(A) site (PAS) interaction. Consistently, SNORD50A depletion altered the Fip1-RNA interaction landscape and changed the alternative polyadenylation (APA) profiles and/or transcript levels of a subset of genes. Taken together, our data revealed a novel function for snoRNAs and provided the first evidence that non-coding RNAs may play an important role in regulating mRNA 3' processing

Controlled growth of atomically thin transition metal dichalcogenides via chemical vapor deposition method

Two-dimensional (2D) transition metal dichalcogenides (TMDC) have attracted great research interest due to their potential application in electronics, optoelectronics, electrocatalysis, and so on. To satisfy expectations, high-quality materials with designed structures are highly desired through the controlled growth of TMDC. Chemical vapor deposition (CVD) offers facile control in synthesizing 2D TMDC as well as a high degree of freedom for tuning their structures and properties. In this review, we elaborate on recent advances in CVD techniques for synthesizing atomically thin TMDC. The novel techniques for achieving continuous uniform 2D films are provided along with insights into the growth mechanisms. Moreover, approaches toward high-quality materials by growing large single crystals and oriented domains are thoroughly summarized. The strategies for controlling the crystal thickness, phase, and doping condition are also discussed. Finally, we address the challenges in the field and prospective research directions