A meta-analysis of phosphate binders lanthanum carbonate versus sevelamer hydrochloride in patients with end-stage renal disease undergoing hemodialysis

Background and Objectives: The purpose of this study was to compare the effects of phosphate binders lanthanum carbonate (LC) versus sevelamer hydrochloride (SH) in end-stage renal disease (ESRD) patients undergoing hemodialysis.Methods: Studies including randomized controlled trials (RCTs) comparing phosphate binders lanthanum carbonate versus sevelamer hydrochloride, in ESRD patients undergoing hemodialysis, were identified using a pre-defined search strategy. Phosphate, calcium, calcium-phosphorus product, intact parathyroid hormone, alkaline phosphatase, total cholesterol, and triglyceride were extracted and compared by RevMan 5.1 (The Cochrane Collaboration, Oxford, UK).Results: Six studies were identified. Meta-analysis showed that SH treatment reduced levels of phosphate, intact parathyroid hormone, and total serum alkaline phosphatase (ALP) when compared with LC treatment. Furthermore, patients on SH treatment tended to have reduced calcium levels, calcium-phosphorus product, total cholesterol, and triglyceride when compared to patients treated with LC, but there was no statistical difference.Conclusion: SH treatment of patients with ESRD is more effective compared to LC treatment. However, more well-designed random control trails are required for confirmation.Keywords: End-stage renal disease, hemodialysis, phosphate binders, lanthanum carbonate (LC), sevelamer hydrochloride (SH), meta-analysis

Simultaneous Detection of Chlamydia Trachomatis, Neisseria Gonorrhoeae, Ureaplasma Urealyticum by Multiplex PCR-Running

Chlamydia trachomatis (CT), Ureaplasma urealyticum (UU) and Neisseria gonorrhoeae (NG) are the most common pathogens of sexually transmitted infections (STIs), frequently founded in urogenital infections, and showed a criminal role in increasing the risk of potential adverse outcomes. In this study a multiplex PCR assay for the simultaneous detection and accurate identification of 3 clinically relevant pathogens of STIs, i.e., CT, NG and UU in a single tube was developed and evaluated. The limits of detection for the multiplex PCR assay were ~10 copies of DNAs per reaction. This assay has comparable clinical sensitivity to the conventional monoplex real-time PCR assay and considerable potential to be routine molecular diagnostic tool for simultaneous identification of STIs at relatively low cost due to multiplexing

A meta-analysis of phosphate binders lanthanum carbonate versus sevelamer hydrochloride in patients with end-stage renal disease undergoing hemodialysis

Background and Objectives: The purpose of this study was to compare the effects of phosphate binders lanthanum carbonate (LC) versus sevelamer hydrochloride (SH) in end-stage renal disease (ESRD) patients undergoing hemodialysis. Methods: Studies including randomized controlled trials (RCTs) comparing phosphate binders lanthanum carbonate versus sevelamer hydrochloride, in ESRD patients undergoing hemodialysis, were identified using a pre-defined search strategy. Phosphate, calcium, calcium-phosphorus product, intact parathyroid hormone, alkaline phosphatase, total cholesterol, and triglyceride were extracted and compared by RevMan 5.1 (The Cochrane Collaboration, Oxford, UK). Results: Six studies were identified. Meta-analysis showed that SH treatment reduced levels of phosphate, intact parathyroid hormone, and total serum alkaline phosphatase (ALP) when compared with LC treatment. Furthermore, patients on SH treatment tended to have reduced calcium levels, calcium-phosphorus product, total cholesterol, and triglyceride when compared to patients treated with LC, but there was no statistical difference. Conclusion: SH treatment of patients with ESRD is more effective compared to LC treatment. However, more well-designed random control trails are required for confirmation

A systematic review and meta-analyses of the relationship between glutathione S-transferase gene polymorphisms and renal cell carcinoma susceptibility

Abstract Background Association of GSTM1- and GSTT1-null genotypes, GSTP1 A/G gene polymorphism with renal cell carcinoma (RCC) susceptibility was detected, and the relationship between the GSTM1/GSTT1-null genotype and clinical TNM stages of RCC was assessed, using meta-analysis method. Methods Association investigations according to eligibility criteria were searched and identified from the databases of Cochrane Library, PubMed, and Embase from establishment time of databases to July 1, 2017, and eligible reports were analyzed by meta-analysis. 95% confidence intervals (CI) were also detected, and odds ratios (OR) was used to express the results for dichotomous data. Results This meta-analysis indicated that there was no an association between GSTM1-null genotype, GSTT1-null genotype, GSTP1 A/G gene polymorphism and RCC risk in the overall population of Caucasians or Asians. The dual GSTM1–GSTT1-null genotype was also not associated with RCC in the overall population of Caucasians. Interestingly, there was an association between the dual GSTM1-GSTT1-null genotype and the susceptibility of RCC in Asians. Relationship of the GSTM1-null genotype with clinical TNM stage of RCC was not observed in the overall population of Asians or Caucasians. In this meta-analysis, no association between the GSTT1-null genotype and clinical TNM stage of RCC was observed in Caucasians or Asians. Interestingly, GSTT1-null genotype was detected to be associated with the clinical TNM stages in patients with RCC in the overall population. Conclusion The dual GSTM1-GSTT1-null genotype is detected to be associated with the onset of RCC in Asians, and there is an association between the GSTT1-null genotype and the clinical TNM stages in patients with RCC in the overall population

Fabrication of Temperature Sensors with High-Performance Uniformity through Thermal Annealing

It is considered to be of great significance to monitor human health and track the effect of drugs by measuring human temperature mapping through flexible temperature sensors. In this work, we found that the thermal annealing of flexible temperature sensors based on graphite–acrylate copolymer composites can not only improve the temperature coefficient of resistance (TCR) values of the devices, but also greatly improve the uniformity of the performance of the devices prepared in parallel. The best results were obtained when the devices were annealed at 100 °C, which is believed to be due to the rearrangement of graphite particles to generate more uniform and numerous conductive channels within the conductive composite. We believe this finding might promote the practical development of flexible temperature sensors in body temperature sensing for health maintenance and medical applications

Fabrication of Temperature Sensors with High-Performance Uniformity through Thermal Annealing

It is considered to be of great significance to monitor human health and track the effect of drugs by measuring human temperature mapping through flexible temperature sensors. In this work, we found that the thermal annealing of flexible temperature sensors based on graphite–acrylate copolymer composites can not only improve the temperature coefficient of resistance (TCR) values of the devices, but also greatly improve the uniformity of the performance of the devices prepared in parallel. The best results were obtained when the devices were annealed at 100 °C, which is believed to be due to the rearrangement of graphite particles to generate more uniform and numerous conductive channels within the conductive composite. We believe this finding might promote the practical development of flexible temperature sensors in body temperature sensing for health maintenance and medical applications

歷史的建構 = The construction of history

Paper Presented by: 沈思: 以文化研究角度看端午節的歷史觀 謝玉蘭: 從香港蘇豪看歷史不同呈現方式 梁寶珊: 傳統再造 – 長州太平清醮與中環廟會 韓麗珠: 2003年春天的集體回憶 – 沙士期間人與人之間距離的改變 嚴偉基: 記憶像鐵軌一樣長 - 電影《阿飛正傳》與《2046》中的列車意

Additional file 1: of A systematic review and meta-analyses of the relationship between glutathione S-transferase gene polymorphisms and renal cell carcinoma susceptibility

Table S1. Scale for Quality Assessment. (DOC 44 kb