A review of optimal planning active distribution system:Models, methods, and future researches

Due to the widespread deployment of distributed energy resources (DERs) and the liberalization of electricity market, traditional distribution networks are undergoing a transition to active distribution systems (ADSs), and the traditional deterministic planning methods have become unsuitable under the high penetration of DERs. Aiming to develop appropriate models and methodologies for the planning of ADSs, the key features of ADS planning problem are analyzed from the different perspectives, such as the allocation of DGs and ESS, coupling of operation and planning, and high-level uncertainties. Based on these analyses, this comprehensive literature review summarizes the latest research and development associated with ADS planning. The planning models and methods proposed in these research works are analyzed and categorized from different perspectives including objectives, decision variables, constraint conditions, and solving algorithms. The key theoretical issues and challenges of ADS planning are extracted and discussed. Meanwhile, emphasis is also given to the suitable suggestions to deal with these abovementioned issues based on the available literature and comparisons between them. Finally, several important research prospects are recommended for further research in ADS planning field, such as planning with multiple micro-grids (MGs), collaborative planning between ADSs and information communication system (ICS), and planning from different perspectives of multi-stakeholders

Frequent copy number variations of PI3K/AKT pathway and aberrant protein expressions of PI3K subunits are associated with inferior survival in diffuse large B cell lymphoma

BACKGROUND: It has been reported that the PI3K/AKT signaling pathway is activated in diffuse large B-cell lymphoma (DLBCL), PI3K constitutive activation plays a crucial role in PI3K/AKT pathway. However, the copy number variations (CNVs) of PI3K subunits on gene level remain unknown in DLBCL. Therefore, the aim of the study is to investigate the CNV of PI3K subunits and their relationship with clinicopathological features exploring the possible mechanism underlying of PI3K activation in DLBCL. METHODS: CNV of 12 genes in the PI3K/AKT pathway was detected by NanoString nCounter in 60 de novo DLBCLs and 10 reactive hyperplasia specimens as controls. Meanwhile, immunohistochemistry (IHC) was performed to examine the expression of p110α, p110β, p110γ, p110δ, and pAKT on DLBCL tissue microarrays. RESULTS: All PI3K and AKT subunits, except for PIK3R1, had various CNVs in the form of copy number amplifications and copy number losses. Their rates were in the range of 8.3–20.0%. Of them PIK3CA and PIK3CB gene CNVs were significantly associated with decreased overall survival (P = 0.029 and P = 0.019, respectively). IHC showed that the frequency of strong positive expression of p110α, p110β, p110γ, and p110δ were 26.7%, 25.0%, 18.3%, and 25.0% respectively, and they were found to be associated with decreased survival (P = 0.022, P = 0.015, P = 0.015, and P = 0.008, respectively). Expression of p110α was not only significantly associated with CNVs of PIK3CA (P = 0.002) but also positively correlated with strong positive expression of pAKT (P = 0.026). CONCLUSIONS: CNV of PIK3CA is highly associated with aberrant p110α protein expression and subsequent activation of PI3K/AKT pathway. CNVs of PIK3CA and PIK3CB, and aberrant protein expression of p110 isoforms are of great important value for predicting inferior prognosis in DLBCL. Frequent CNVs of PI3K/AKT subunits may play an important role in the tumorigenesis of DLBCL

Activation of MET signaling by HDAC6 offers a rationale for a novel ricolinostat and crizotinib combinatorial therapeutic strategy in diffuse large B‐cell lymphoma

Some histone deacetylases (HDACs) promote tumor cell growth and pan‐ or selective HDAC inhibitors are active in some cancers; however, the pivotal HDAC enzyme and its functions in human diffuse large B‐cell lymphoma (DLBCL) remain largely unknown. Using NanoString nCounter assays, we profiled HDAC mRNA expression and identified HDAC6 as an upregulated HDAC family member in DLBCL tissue samples. We then found that HDAC6 plays an oncogenic role in DLBCL, as evidenced by its promotion of cell proliferation in vitro and tumor xenograft growth in vivo. Mechanistically, the interaction between HDAC6 and HR23B downregulated HR23B expression, thereby reducing the levels of casitas B‐lineage lymphoma (c‐Cbl), an E3 ubiquitin ligase for hepatocyte growth factor receptor (MET), which resulted in the inhibition of MET ubiquitination‐dependent degradation. In addition, enhanced HDAC6 expression and decreased HR23B expression were correlated with poor overall survival rates among patients with DLBCL. Taken together, these results establish an HDAC6–HR23B–MET axis and indicate that HDAC6 is a potent promoter of lymphomagenesis in DLBCL. Thus, a therapeutic strategy based on HDAC6 inhibitors in combination with MET inhibitors is promising. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146400/1/path5108_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146400/2/path5108.pd

Test of Perfomance ERK Hybrid Dryer with Biomass Furnace as Additional Heating System for Nutmeg Seed (Myristica SP.) Drying

Conventional drying depend on the weather. It was caused agricultural product damaged, and moldy attack. So we need hybrid dryer with a source of radiation and solar biomass to continuous drying and can be controlled.The aims of this research is test performance of ERK hybrid dryer to drying the nutmeg seed during the drying process. Experiments were conducted to determine the distribution of temperature in the dryer in condition with no material and material conditions. Input of energy derived from biomass combustion in the furnace (evening) and combination of biomass and radiation (during the day). Measurements of temperature and RH using a thermocouple CC and alcohol thermometer. Temperature and RH to be measured include temperature and RH in dryer with several measurement points representing the up, middle , bottom and inlet temperature, outlet temperature and ambient temperature measurements at intervals of 30 minutes. The results showed average temperature ranges between 42 ° C - 51 ° C and RH ranged between 50.96 % -55.65 % . Time of drying is used to dry nutmeg from the initial moisture content from 80.72 % wb to 9.67 % wb is 52 hours with an average drying rate is 7.8 % db / hour . The total energy used to heat and vaporize materials,water that is 290 499.9 kJ. Efficiency of drying system 8.63% and energy of drying required to water evaporated is 28520.62 kJ / kg. The result quality of product obtained color of nutmeg generally more uniform

Persepsi Masyarakat terhadap Alun-alun Kota Bandung sebagai Ruang Terbuka Publik

Bandung merupakan sebuah kota yang strategis yang memiliki nilai sejarah yang cukup panjang dalam masa perjuangan. Alun alun Bandung merupakan hasil warisan ciri kota tradisional yang dibangun oleh penguasa kolonial yang merupakan pusat ruang terbuka kota. Dari masa kemasa Alun-alun kota Bandung telah mengalami beberapa kali Perubahan, baik bentuk maupun fungsinya sehingga mengakibatkan degradasi makna terhadap fungsinya bagi masyarakat Kota Bandung itu sendiri. Maka fenomena tersebut mengarahkan kepada pertanyaan penelitian yaitu bagaimana persepsi masyarakat terhadap Alun-alun Kota Bandung ditinjau sebagai ruang terbuka publik. Tujuan penelitian ini adalah untuk mengetahui persepsi masyarakat terhadap Alun-alun Kota Bandung. Dari tujuan tersebut maka sasaran yang dilakukan adalah mengidentifikasi karakter dan fungsi ruang terbuka publik yaitu fungsi ekologis, arsitektural, dan sosial. Dari hasil analisis dengan menggunakan kuesioner yaitu uji sampel dengan regresi linear sederhana dengan pendekatan analisis pengguna dan analisis karakteristik ruang terbuka publik. Hasil penelitian ini menghasilkan penilaian baik terhadap korelasi variabel bebas yaitu persepsi masyarakat terhadap variabel terikat yaitu Alun-alun Kota Bandung, setiap kali pertanyaan yang berkenaan dengan Persepsi masyarakat terhadap Alun-alun Kota Bandung akan mempengaruhi nilai hasil pengujian yang cenderung meningkat akan keberadaan Alun-alun itu sendiri. Hasil penelitian ini bisa dimanfaatkan untuk mengangkat kembali citra Alun-alun Kota Bandung sebagai ruang publik atau (Central Square).[Public Perception of The Alun-alun Bandung as Public Open Space] Bandung is a city that has a value that strategic long history in the struggle. Alun Bandung square is the result of inherited traits of traditional town built by the colonial rulers which is the center of the city open space. Over time, Bandung town square has undergone several changes, both form and function, resulting in degradation of the meaning of the function for the city of London itself. The phenomenon then leads to the research question is how the public perception of the square is the city of Bandung reviewed as public open space for the present study tries to analyze the function of the existence of Bandung City Square as a public space. The purpose of this study was to determine the public perception of the square is the city of Bandung. From these objectives, the target does is identify the character and function of public open space that is the function of ecological, architectural and social. From the analysis by using a questionnaire that test samples with a simple linear regression analysis approach and analysis of the characteristics of users of public open space. The results of this study resulted in better assessment of the correlation of the independent variable is the public perception of the dependent variable is the town square of Bandung, every time queries regarding the public\u27s perception of the town square Bandung will affect the value of the test results are likely to increase in the existence Square itself. the results of this study can be used to lift the image of Bandung city square as a public space or (Central Square)

Hyaluronan–CD44 Interaction Promotes Oncogenic Signaling, microRNA Functions, Chemoresistance, and Radiation Resistance in Cancer Stem Cells Leading to Tumor Progression

Hyaluronan (HA), a major component of the extracellular matrix (ECM), is enriched in many types of tumors. There is good evidence linking high levels of HA production in human carcinomas to an aggressive phenotype and tumor metastasis. HA is generally bound to CD44 isoforms (so-called CD44s and CD44v3) which are ubiquitous, abundant, and functionally important cell surface receptors. This chapter describes the evidence for HA/CD44v3-mediated activation of the cytoskeleton (e.g., ankyrin and GTPases) and matrix metalloproteinase (MMP) signaling during tumor progression. A special focus is placed on the role of HA-CD44v3 interaction in cancer stem cells (CSCs). Matrix HA is known to be present in CSC niches. Since CD44v3 serves as a CSC marker, it provides an important physical linkage between matrix HA and various transcription factors that regulate tumor cell functions through distinct signaling pathways. CSCs are known to be chemoresistant and/or radiation resistant and to cause cancer relapse. The purpose of this chapter is to review the most current research on the cellular and molecular biology of CSCs. The emphasis will be placed on both CSC niche and matrix HA-induced microRNA signaling plus various CSC functions (e.g., self-renewal, differentiation, and chemoresistance) during cancer progression. Understanding the regulation of CSCs is critically important for designing CSC-specific therapeutic targets to prevent cancer development and progression