Inequalities for Light Nuclei in the Wigner Symmetry Limit

Using effective field theory we derive inequalities for light nuclei in the Wigner symmetry limit. This is the limit where isospin and spin degrees of freedom can be interchanged. We prove that the energy of any three-nucleon state is bounded below by the average energy of the lowest two-nucleon and four-nucleon states. We show how this is modified by lowest-order terms breaking Wigner symmetry and prove general energy convexity results for SU(N). We also discuss the inclusion of Wigner-symmetric three and four-nucleon force terms.Comment: 10 page

On the Quark Mass Dependence of Two Nucleon Observables

We study the implications of lattice QCD determinations of the S-wave nucleon-nucleon scattering lengths at unphysical light quark masses. It is found that with the help of nuclear effective field theory (NEFT), not only the quark mass dependence of the effective range parameters, but also the leading quark mass dependence of all the low energy deuteron matrix elements can be obtained. The quark mass dependence of deuteron charge radius, magnetic moment, polarizability and the deuteron photodisintegration cross section are shown based on the NPLQCD lattice calculation of the scattering lengths at 354 MeV pion mass and the NEFT power counting scheme of Beane, Kaplan and Vuorinen. Further improvement can be obtained by performing the lattice calculation at smaller quark masses. Our result can be used to constrain the time variation of isoscalar combination of u and d quark mass m_q, to help the anthropic principle study to find the m_q range which allows the existence of life, and to provide a weak test of the multiverse conjecture.Comment: 18 pages, 5 figure

Photoluminescence Study of Hydrothermally Grown ZnO Nanostructures

In this work, the hydrothermally grown ZnO nanostructures were successfully prepared using the aqueous solution of zinc nitride dehydrate (Zn(NO3)2). The effect of solution molarity on the optical and structural properties of ZnO nanostructures were studied by temperature dependent photoluminescence (PL) measurements. The intensity ratio of the ultraviolet emission to the visible emission is calculated. It is found that the calculated results are also dependent on the solution molarity and consistent with the crystal quality of ZnO nanostructures

Mutations in the Salmonella enterica serovar Choleraesuis cAMP-receptor protein gene lead to functional defects in the SPI-1 Type III secretion system

Salmonella enterica serovar Choleraesuis (Salmonella Choleraesuis) causes a lethal systemic infection (salmonellosis) in swine. Live attenuated Salmonella Choleraesuis vaccines are effective in preventing the disease, and isolates of Salmonella Choleraesuis with mutations in the cAMP-receptor protein (CRP) gene (Salmonella Choleraesuis ∆crp) are the most widely used, although the basis of the attenuation remains unclear. The objective of this study was to determine if the attenuated phenotype of Salmonella Choleraesuis ∆crp was due to alterations in susceptibility to gastrointestinal factors such as pH and bile salts, ability to colonize or invade the intestine, or cytotoxicity for macrophages. Compared with the parental strain, the survival rate of Salmonella Choleraesuis ∆crp at low pH or in the presence of bile salts was higher, while the ability of the mutant to invade intestinal epithelia was significantly decreased. In examining the role of CRP on the secretory function of the Salmonella pathogenicity island 1 (SPI-1) encoded type III secretion system (T3SS), it was shown that Salmonella Choleraesuis ∆crp was unable to secrete the SPI-1 T3SS effector proteins, SopB and SipB, which play a role in Salmonella intestinal invasiveness and macrophage cytotoxicity, respectively. In addition, caspase-1 dependent cytotoxicity for macrophages was significantly reduced in Salmonella Choleraesuis ∆crp. Collectively, this study demonstrates that the CRP affects the secretory function of SPI-1 T3SS and the resulting ability to invade the host intestinal epithelium, which is a critical element in the pathogenesis of Salmonella Choleraesuis

A Holographic Model For Hall Viscosity

We have modified the holographic model of Saremi and Son by using a charged black brane, instead of a neutral one, such that when the bulk pseudo scalar potential is made of quadratic and quartic terms, parity can still be broken spontaneously in the boundary theory. In our model, the 3+1 dimensional bulk has a pseudo scalar coupled to the gravitational Chern-Simons term in the anti de Sitter charged black brane back ground. Parity could be broken spontaneously in the bulk by the pseudo scalar hairy solution and give rise to non-zero Hall viscosity at the boundary theory.Comment: 15 pages, 4 figure

Elastic and Inelastic Neutrino-Deuteron Scattering in Effective Field Theory

The differential cross-sections for elastic and inelastic neutrino-deuteron scattering are calculated analytically using nucleon-nucleon effective field theory. For elastic scattering, the deuteron axial form factor and the deuteron strange magnetic moment form factor are computed to next-to-leading order, including two-body currents. For inelastic scattering, two neutral current processes nu+d->nu+n+p, nubar+d->nubar+n+p and one charged current process nubar+d->(e^+)+n+n are computed to next-to-leading order. These depend on an isovector axial two-body matrix element whose value is yet to be fixed by experiment. Potential model calculations by Kubodera et al. and Ying et al. are reproduced for different values of the two-body matrix element. This implies that the differences between the two potential model calculations lie in their treatment of short distance physics. The charged current to neutral current nubar-d cross-section ratio is confirmed to be insensitive to short distance physics, and the same ratio is obtained by potential models and the calculation presented here, within 5%, for incident incident neutrino energies up to 20 MeV. The two-body matrix element could be fixed using the parity violating process epol+d->e+n+p.Comment: 29 pages, 11 figures; An error in the charged current cross section has been corrected. Figures and discussion have been modified accordingl

KCNN2 polymorphisms and cardiac tachyarrhythmias

Potassium calcium-activated channel subfamily N member 2 (KCNN2) encodes an integral membrane protein that forms small-conductance calcium-activated potassium (SK) channels. Recent studies in animal models show that SK channels are important in atrial and ventricular repolarization and arrhythmogenesis. However, the importance of SK channels in human arrhythmia remains unclear. The purpose of the present study was to test the association between genetic polymorphism of the SK2 channel and the occurrence of cardiac tachyarrhythmias in humans. We enrolled 327 Han Chinese, including 72 with clinically significant ventricular tachyarrhythmias (VTa) who had a history of aborted sudden cardiac death (SCD) or unexplained syncope, 98 with a history of atrial fibrillation (AF), and 144 normal controls. We genotyped 12 representative tag single nucleotide polymorphisms (SNPs) across a 141-kb genetic region containing the KCNN2 gene; these captured the full haplotype information. The rs13184658 and rs10076582 variants of KCNN2 were associated with VTa in both the additive and dominant models (odds ratio [OR] 2.89, 95% confidence interval [CI] = 1.505-5.545, P = 0.001; and OR 2.55, 95% CI = 1.428-4.566, P = 0.002, respectively). After adjustment for potential risk factors, the association remained significant. The population attributable risks of these 2 variants of VTa were 17.3% and 10.6%, respectively. One variant (rs13184658) showed weak but significant association with AF in a dominant model (OR 1.91, CI = 1.025-3.570], P = 0.042). There was a significant association between the KCNN2 variants and clinically significant VTa. These findings suggest an association between KCNN2 and VTa; it also appears that KCNN2 variants may be adjunctive markers for risk stratification in patients susceptible to SCD

Neutrino-Deuteron Scattering in Effective Field Theory at Next-to-Next-to Leading Order

We study the four channels associated with neutrino-deuteron breakup reactions at next-to-next to leading order in effective field theory. We find that the total cross-section is indeed converging for neutrino energies up to 20 MeV, and thus our calculations can provide constraints on theoretical uncertainties for the Sudbury Neutrino Observatory. We stress the importance of a direct experimental measurement to high precision in at least one channel, in order to fix an axial two-body counterterm.Comment: 32 pages, 14 figures (eps

Leukocyte Cell-Derived Chemotaxin 2 Retards Non-Small Cell Lung Cancer Progression Through Antagonizing MET and EGFR Activities

Background/Aims: Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) therapy is a clinical option for non-small cell lung cancer (NSCLC) harboring activating EGFR mutations or for cancer with wild-type (WT) EGFR when chemotherapy has failed. MET receptor activation or MET gene amplification was reported to be a major mechanism of acquired resistance to EGFR-TKI therapy in NSCLC cells. Leukocyte cell-derived chemotaxin 2 (LECT2) is a multifunctional cytokine that was shown to suppress metastasis of hepatocellular carcinoma via inhibiting MET activity. Until now, the biological function responsible for LECT2’s action in human NSCLC remains unclear. Methods: LECT2-knockout (KO) mice and NOD/SCID/IL2rgnull (NSG) mice were respectively used to investigate the effects of LECT2 on the tumorigenicity and metastasis of murine (Lewis lung carcinoma, LLC) and human (HCC827) lung cancer cells. The effect of LECT2 on in vitro cell proliferation was evaluated, using MTS and colony formation assays. The effect of LECT2 on cell motility was evaluated using transwell migration and invasion assays. An enzyme-linked immunosorbent assay was performed to detect secreted LECT2 in plasma and media. Co-immunoprecipitation and Western blot assays were used to investigate the underlying mechanisms of LECT2 in NSCLC cells. Results: Compared to WT mice, mice with LECT2 deletion exhibited enhanced growth and metastasis of LLC cells, and survival times decreased in LLC-implanted mice. Overexpression of LECT2 in orthotopic human HCC827 xenografts in NSG mice resulted in significant inhibition of tumor growth and metastasis. In vitro, overexpression of LECT2 or treatment with a recombinant LECT2 protein impaired the colony-forming ability and motility of NSCLC cells (HCC827 and PC9) harboring high levels of activated EGFR and MET. Mechanistic investigations found that LECT2 bound to MET and EGFR to antagonize their activation and further suppress their common downstream pathways: phosphatidylinositol 3-kinase/Akt and extracellular signal-regulated kinase. Conclusion: EGFR-MET signaling is critical for aggressive behaviors of NSCLC and is recognized as a therapeutic target for NSCLC especially for patients with acquired resistance to EGFR-TKI therapy. Our findings demonstrate, for the first time, that LECT2 functions as a suppressor of the progression of NSCLC by targeting EGFR-MET signaling

d+idd+id Holographic Superconductors

A holographic model of $d+id$ superconductors based on the action proposed by Benini, Herzog, and Yarom [arXiv:1006.0731] is studied. This model has a charged spin two field in an AdS black hole spacetime. Working in the probe limit, the normalizable solution of the spin two field in the bulk gives rise to a $d+id$ superconducting order parameter at the boundary of the AdS. We calculate the fermion spectral function in this\ superconducting background and confirm the existence of fermi arcs for non-vanishing Majorana couplings. By changing the relative strength $\gamma$ of the $d$ and $id$ condensations, the position and the size of the fermi arcs are changed. When $\gamma =1$, the spectrum becomes isotropic and the spectral function is s-wave like. By changing the fermion mass, the fermi momentum is changed. We also calculate the conductivity for these holographic $d+id$ superconductors where time reversal symmetry has been broken spontaneously. A non-vanishing Hall conductivity is obtained even without an external magnetic field.Comment: 24 pages,17 figures, Add more discussions on hall conductivity, two new figures, Matched with published versio