Waiting time distribution of solar energetic particle events modeled with a non-stationary Poisson process

We present a study of the waiting time distributions (WTDs) of solar energetic particle (SEP) events observed with the spacecraft $WIND$ and $GOES$. Both the WTDs of solar electron events (SEEs) and solar proton events (SPEs) display a power-law tail $\sim \Delta t^{-\gamma}$. The SEEs display a broken power-law WTD. The power-law index is $\gamma_{1} =$ 0.99 for the short waiting times ($$100 hours). The break of the WTD of SEEs is probably due to the modulation of the corotating interaction regions (CIRs). The power-law index $\gamma \sim$ 1.82 is derived for the WTD of SPEs that is consistent with the WTD of type II radio bursts, indicating a close relationship between the shock wave and the production of energetic protons. The WTDs of SEP events can be modeled with a non-stationary Poisson process which was proposed to understand the waiting time statistics of solar flares (Wheatland 2000; Aschwanden $\&$ McTiernan 2010). We generalize the method and find that, if the SEP event rate $\lambda = 1/\Delta t$ varies as the time distribution of event rate $f(\lambda) = A \lambda^{-\alpha}exp(-\beta \lambda)$, the time-dependent Poisson distribution can produce a power-law tail WTD $\sim \Delta t^{\alpha - 3}$, where $0 \leq \alpha < 2$.Comment: 10 pages, 4 figures, accepted for publication in ApJ Letter

The Emergent Landscape of Detecting EGFR Mutations Using Circulating Tumor DNA in Lung Cancer.

The advances in targeted therapies for lung cancer are based on the evaluation of specific gene mutations especially the epidermal growth factor receptor (EGFR). The assays largely depend on the acquisition of tumor tissue via biopsy before the initiation of therapy or after the onset of acquired resistance. However, the limitations of tissue biopsy including tumor heterogeneity and insufficient tissues for molecular testing are impotent clinical obstacles for mutation analysis and lung cancer treatment. Due to the invasive procedure of tissue biopsy and the progressive development of drug-resistant EGFR mutations, the effective initial detection and continuous monitoring of EGFR mutations are still unmet requirements. Circulating tumor DNA (ctDNA) detection is a promising biomarker for noninvasive assessment of cancer burden. Recent advancement of sensitive techniques in detecting EGFR mutations using ctDNA enables a broad range of clinical applications, including early detection of disease, prediction of treatment responses, and disease progression. This review not only introduces the biology and clinical implementations of ctDNA but also includes the updating information of recent advancement of techniques for detecting EGFR mutation using ctDNA in lung cancer

Tris(1,10-phenanthroline-κ2 N,N′)zinc(II) bis­(4-bromo­benzoate) 6.5-hydrate

In the title compound, [Zn(C12H8N2)3](C7H4BrO2)2·6.5H2O, the ZnII atom is coordinated by six N atoms from three 1,10-phenanthroline (phen) mol­ecules in a distorted octa­hedral geometry. The chelating phen ligands exhibit nearly perfect coplanarity (r.m.s. deviations of 0.048, 0.039 and 0.061 Å). The mean inter­planar distances of 3.51 (2) and 3.54 (4) Å between adjacent phen ligands indicate π–π stacking inter­actions, which connect the complex cations into chains along [101]. The 4-bromo­benzoate anions and the uncoordinated water mol­ecules, parts of which are not fully occupied, are linked by O—H⋯O hydrogen bonds. Two carboxyl­ate O atoms and one Br atom in the 4-bromo­benzoate anions are each disordered over two sites with occupancy factors of 0.60 and 0.40

Liquid biopsy genotyping in lung cancer: ready for clinical utility?

Liquid biopsy is a blood test that detects evidence of cancer cells or tumor DNA in the circulation. Despite complicated collection methods and the requirement for technique-dependent platforms, it has generated substantial interest due, in part, to its potential to detect driver oncogenes such as epidermal growth factor receptor (EGFR) mutants in lung cancer. This technology is advancing rapidly and is being incorporated into numerous EGFR tyrosine kinase inhibitor (EGFR-TKI) development programs. It appears ready for integration into clinical care. Recent studies have demonstrated that biological fluids such as saliva and urine can also be used for detecting EGFR mutant DNA through application other user-friendly techniques. This review focuses on the clinical application of liquid biopsies to lung cancer genotyping, including EGFR and other targets of genotype-directed therapy and compares multiple platforms used for liquid biopsy

改良穴位图谱在中医护理操作中运用效果评价

Objective To find an effective study method to master the nursing procedures of acupoints that will be applied in the clinical nursing work. Methods Based on the Chinese medicine hospital of traditional Chinese medicine nursing guidelines (trial version) published by the bureau of traditional Chinese medicine and given full expression to the advantages of the Traditional Chinese Medicine, acupoints map was improved and was applied in clinical work in August 2011 in our hospital. The nursing operation workload and learning effect in the continuity two years were compared by retrospective investigation combined with questionnaire survey. Results 1, The operation workload increases obviously and the overall growth rate in five work targets is 88.66%, after improving acupoints map of TCM nursing. 2, There are significant differences (P &lt; 0.001) on learning interest, learning degree, memory speed, knowledge of diseas, method of operation and clinical application in our comparison.Conclusion The improved acupoints map can inspire the learning interest of the nursing stuff, help them to master common nursing acupoints of traditional Chinese medicine quickly and apply it to clinical disease. There are good social and economic benefits of this method, so it is worth promoting.目的 寻找一种有效掌握中医护理穴位的学习方法并运用于临床护理工作中。 方法 以中医药局印发《中医医院中医护理工作指南(试行)》文件的内容为指导思想，全面体现中医特色和优势。本院积极开展中医护理操作，于2011年8月设计改良穴位图谱并运用于临床。采用回顾性调查并结合问卷式调查，比较实施前后一年期间中医护理操作工作量及学习效果。结果 （1）2011年8月采用改良穴位图谱后中医护理操作工作量明显增长，五项工作量的总体增长率达88.66%；（2）采用改良穴位图谱前后护士在学习兴趣、易学程度、记忆速度、疾病腧穴知识、操作方法、临床应用等方面比较均有显著性差异（P＜0.001）。 结论 采取改良穴位图谱学习方法能提高护理人员对穴位的学习兴趣，快速掌握中医护理疾病的常用腧穴并应用于临床，赢得了较好的社会效益和经济效益，值得推广

Use of an open-source CAD software program and additive manufacturing technology to design and fabricate a definitive cast for retrofitting a crown to an existing removable partial denture

This technical report describes a digital process for designing and fabricating a stackable definitive cast and die system to facilitate the fabrication of a new surveyed crown to retrofit to a removable partial denture (RPD). By using an open-source computer-aided design (CAD) software program, this technique provides an economical option for dental clinicians and laboratory technicians to use intraoral scans and design a stackable definitive cast and die system with minimal financial investment in the CAD software. In addition, this technique provides the advantage of a conventional indirect technique in that it can create a definitive cast with an RPD clasp assembly ready for the dental technician to properly contour the new surveyed crown, but without the need for the patient to be without the RPD during the process

DNMT3a in the hippocampal CA1 is crucial in the acquisition of morphine self‐administration in rats

Drug‐reinforced excessive operant responding is one fundamental feature of long-lasting addiction‐like behaviors and relapse in animals. However, the transcriptional regulatory mechanisms responsible for the persistent drug‐specific (not natural rewards) operant behavior are not entirely clear. In this study, we demonstrate a key role for one of the de novo DNA methyltransferase, DNMT3a, in the acquisition of morphine self‐administration (SA) in rats. The expression of DNMT3a in the hippocampal CA1 region but not in the nucleus accumbens shell was significantly up‐regulated after 1‐ and 7‐day morphine SA (0.3 mg/kg/infusion) but not after the yoked morphine injection. On the other hand, saccharin SA did not affect the expression of DNMT3a or DNMT3b. DNMT inhibitor 5‐aza‐2‐deoxycytidine (5‐aza) microinjected into the hippocampal CA1 significantly attenuated the acquisition of morphine SA. Knockdown of DNMT3a also impaired the ability to acquire the morphine SA. Overall, these findings suggest that DNMT3a in the hippocampus plays an important role in the acquisition of morphine SA and may be a valid target to prevent the development of morphine addiction. Includes Supplemental informatio

Nucleon-nucleon momentum correlation function for light nuclei

Nucleon-nucleon momentum correlation function have been presented for nuclear reactions with neutron-rich or proton-rich projectiles using a nuclear transport theory, namely Isospin-Dependent Quantum Molecular Dynamics model. The relationship between the binding energy of projectiles and the strength of proton-neutron correlation function at small relative momentum has been explored, while proton-proton correlation function shows its sensitivity to the proton density distribution. Those results show that nucleon-nucleon correlation function is useful to reflect some features of the neutron- or proton-halo nuclei and therefore provide a potential tool for the studies of radioactive beam physics.Comment: Talk given at the 18th International IUPAP Conference on Few-Body Problems in Physics (FB18), Santos, Brasil, August 21-26, 2006. To appear in Nucl. Phys.