Clinical management of a child with melanotic neuroectodermal tumour of infancy

A rare case of melanotic neuroectodermal tumour of infancy affecting the maxilla is reported. These are rare, mainly benign neoplasms that present during infancy. Prompt surgery and rehabilitation using partial dentures are essential to minimise the effects of the deformity. The integrated surgical and prosthodontic management needed to attain good restoration of aesthetic and masticatory function in a child are emphasised. Additional partial dentures need to be made that accommodate the changes in the dental arch that occur as the child grows.published_or_final_versio

Ultrafast spectrum observation based on visualized spectro-temporal analyzer (ViSTA)

We present an ultrafast optical spectrum analyzing modality known as visualized spectro-temporal analyzer, which leverages the time-lens focusing mechanism, can realize frame rate as high as 100 MHz, with 0.02-nm resolution and –30-dBm detection sensitivity. © 2013 Optical Society of Americapublished_or_final_versio

Estimating Risks of Inapparent Avian Exposure for Human Infection: Avian Influenza Virus A (H7N9) in Zhejiang Province, China

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Regional Transport and Its Association with Tuberculosis in the Shandong Province of China, 2009-2011

Human mobility has played a major role in the spread of infectious diseases such as tuberculosis (TB) through transportation; however, its pattern and mechanism have remained unclear. This study used transport networks as a proxy for human mobility to generate the spatial process of TB incidence. It examined the association between TB incidence and four types of transport networks at the provincial level: provincial roads, national roads, highways, and railways. Geographical information systems and geospatial analysis were used to examine the spatial distribution of 2217 smear-positive TB cases reported between 2009 and 2011 in the Shandong province. The study involved factors such as population density and elevation difference in conjunction with the types of transport networks to predict the disease occurrence in space. It identified spatial clusters of TB incidence linked not only with transport networks of the regions but also differentiated by elevation. Our research findings provide evidence of targeting populous regions with well-connected transport networks for effective surveillance and control of TB transmission in Shandong.postprin

Direct Copper Plating to IWO for Silicon Heterojunction Solar Cells

Indium tungsten oxide (IWO) can provide advantages over indium tin oxide (ITO) as a transparent conducting oxide silicon heterojunction (SHJ) solar cells due to its lower absorption in the long wavelength region. However, lowtemperature metallization methods are required for IWO-coated cells. This paper introduces a new process for the direct Cu plating to IWO surfaces for SHJ cells. The process, which employs a rapidly-plated initial seed Cu layer, can achieve strong interfacial adhesion and specific resistivity values as low as 1.81 ± 0.32 m∼ W -cm 2

Simultaneous dual-band optical coherence tomography for endoscopic applications

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A Self Healing Microservices Architecture: A Case Study in Docker Swarm Cluster

One desired aspect of a self-adapting microservices architecture is the ability to continuously monitor the operational environment, detect and observe anomalous behaviour as well as implement a reasonable policy for self-scaling, self-healing, and self-tuning the computational resources in order to dynamically respond to a sudden change in its operational environment. Often the behaviour of a microservices architecture continuously changes over time and the identification of both normal and abnormal behaviours of running services becomes a challenging task. This paper proposes a self-healing Microservice architecture that continuously monitors the operational environment, detects and observes anomalous behaviours, and provides a reasonable adaptation policy using a multi-dimensional utility-based model. This model preserves the cluster state and prevents multiple actions to taking place at the same time. It also guarantees that the executed adaptation action fits the current execution context and achieves the adaptation goals. The results show the ability of this model to dynamically scale the architecture horizontally or vertically in response to the context changes

Genetically predicted circulating protein biomarkers and ovarian cancer risk.

OBJECTIVE: Most women with epithelial ovarian cancer (EOC) are diagnosed after the disease has metastasized and survival in this group remains poor. Circulating proteins associated with the risk of developing EOC have the potential to serve as biomarkers for early detection and diagnosis. We integrated large-scale genomic and proteomic data to identify novel plasma proteins associated with EOC risk. METHODS: We used the germline genetic variants most strongly associated (P <1.5 × 10-11) with plasma levels of 1329 proteins in 3301 healthy individuals from the INTERVAL study to predict circulating levels of these proteins in 22,406 EOC cases and 40,941 controls from the Ovarian Cancer Association Consortium (OCAC). Association testing was performed by weighting the beta coefficients and standard errors for EOC risk from the OCAC study by the inverse of the beta coefficients from INTERVAL. RESULTS: We identified 26 proteins whose genetically predicted circulating levels were associated with EOC risk at false discovery rate < 0.05. The 26 proteins included MFAP2, SEMG2, DLK1, and NTNG1 and a group of 22 proteins whose plasma levels were predicted by variants at chromosome 9q34.2. All 26 protein association signals identified were driven by association with the high-grade serous histotype that comprised 58% of the EOC cases in OCAC. Regional genomic plots confirmed overlap of the genetic association signal underlying both plasma protein level and EOC risk for the 26 proteins. Pathway analysis identified enrichment of seven biological pathways among the 26 proteins (Padjusted <0.05), highlighting roles for Focal Adhesion-PI3K-Akt-mTOR and Notch signaling. CONCLUSION: The identified proteins further illuminate the etiology of EOC and represent promising new EOC biomarkers for targeted validation by studies involving direct measurement of plasma proteins in EOC patient cohorts

Comammox Nitrospira Clade B is the most abundant complete ammonia oxidizer in a dairy pasture soil and inhibited by dicyandiamide and high ammonium concentrations

The recent discovery of comammox Nitrospira, a complete ammonia oxidizer, capable of completing the nitrification on their own has presented tremendous challenges to our understanding of the nitrification process. There are two divergent clades of comammox Nitrospira, Clade A and B. However, their population abundance, community structure and role in ammonia and nitrite oxidation are poorly understood. We conducted a 94-day microcosm study using a grazed dairy pasture soil amended with urea fertilizers, synthetic cow urine, and the nitrification inhibitor, dicyandiamide (DCD), to investigate the growth and community structure of comammox Nitrospira spp. We discovered that comammox Nitrospira Clade B was two orders of magnitude more abundant than Clade A in this fertile dairy pasture soil and the most abundant subcluster was a distinctive phylogenetic uncultured subcluster Clade B2. We found that comammox Nitrospira Clade B might not play a major role in nitrite oxidation compared to the role of canonical Nitrospira nitrite-oxidizers, however, comammox Nitrospira Clade B is active in nitrification and the growth of comammox Nitrospira Clade B was inhibited by a high ammonium concentration (700 kg synthetic urine-N ha¯¹) and the nitrification inhibitor DCD. We concluded that comammox Nitrospira Clade B: (1) was the most abundant comammox in the dairy pasture soil; (2) had a low tolerance to ammonium and can be inhibited by DCD; and (3) was not the dominant nitrite-oxidizer in the soil. This is the first study discovering a new subcluster of comammox Nitrospira Clade B2 from an agricultural soil