4,319 research outputs found

    Peptides as Promising Non-Viral Vectors for Gene Therapy

    Get PDF

    Effects of pedestrian excitation on two short-span FRP footbridges in Delft

    Get PDF
    This is the author accepted manuscript. The final version is available from the publisher via the DOI in this recordReported in this paper is an evaluation of the vibration behaviour of two footbridges in The Netherlands having main spans of about 15, m. Short-span footbridges over canals and rivers are embedded in the landscape of Delft and elsewhere. Increasingly, these bridges are made of Fibre-Reinforced Polymer (FRP) composites, utilising the high-strength and light-weight nature of the material, and taking advantage of fast installation and low maintenance costs. Due to low mass, these FRP bridges might be sensitive to dynamic excitation by human actions. The two footbridges investigated in this paper have the main bearing structure which consists of either two or four longitudinal beams made of vacuum infused FRPs with foam cores connected by an FRP deck. Modal testing revealed that fundamental vertical natural frequency of the two structures at 4.8 and 6.1, Hz is in the range typical of similar structures made of concrete and steel, whilst the corresponding damping ratio for the wider, slightly cambered, bridge was exceptionally high at 7.9%. The vibration response to dynamic force by people walking was typically up to 1, m/s 2 . While both of these light-weight structures performed satisfactorily under the regular pedestrian loading, the higher frequency – higher damping structure represents an example of successful control of pedestrian-induced vibrations by means of longitudinal restraints at the end supports and slightly curved shape of the main structure.Engineering and Physical Sciences Research Council (EPSRC

    Experimental demonstration of a hyper-entangled ten-qubit Schr\"odinger cat state

    Full text link
    Coherent manipulation of an increasing number of qubits for the generation of entangled states has been an important goal and benchmark in the emerging field of quantum information science. The multiparticle entangled states serve as physical resources for measurement-based quantum computing and high-precision quantum metrology. However, their experimental preparation has proved extremely challenging. To date, entangled states up to six, eight atoms, or six photonic qubits have been demonstrated. Here, by exploiting both the photons' polarization and momentum degrees of freedom, we report the creation of hyper-entangled six-, eight-, and ten-qubit Schr\"odinger cat states. We characterize the cat states by evaluating their fidelities and detecting the presence of genuine multi-partite entanglement. Small modifications of the experimental setup will allow the generation of various graph states up to ten qubits. Our method provides a shortcut to expand the effective Hilbert space, opening up interesting applications such as quantum-enhanced super-resolving phase measurement, graph-state generation for anyonic simulation and topological error correction, and novel tests of nonlocality with hyper-entanglement.Comment: 11 pages, 5 figures, comments welcom

    Psychometric properties of a prostate cancer radiation late toxicity questionnaire

    Get PDF
    <p>Abstract</p> <p>Background</p> <p>To construct a short prostate cancer radiation late toxicity (PCRT) questionnaire with health-related quality-of-life (HRQoL) domains.</p> <p>Methods</p> <p>The PCRT was developed by item generation, questionnaire construction (n = 7 experts, n = 8 focus group patients), pilot testing (n = 37), item reduction (n = 100), reliability testing (n = 237), and validity testing (n = 274).</p> <p>Results</p> <p>Reliability of the three item-reduced subscales demonstrated intraclass correlation coefficients (CC) of 0.811 (GU), 0.842 (GI), and 0.740 (sexual). Discriminant validity demonstrated Pearson CC of 0.449 (GU-GI), 0.200 (sexual-GU), and 0.09 (sexual-GI). Content validity correlations between PCRT-PCQoL were 0.35–0.78, PCRT-FACT-G<sup>© </sup>were 0.19–0.39, and PCRT-SF-36<sup>® </sup>were 0.03–0.34.</p> <p>Conclusion</p> <p>We successfully generated a PCRT HRQoL questionnaire including subscales with very good psychometric properties.</p

    Multi-step self-guided pathways for shape-changing metamaterials

    Get PDF
    Multi-step pathways, constituted of a sequence of reconfigurations, are central to a wide variety of natural and man-made systems. Such pathways autonomously execute in self-guided processes such as protein folding and self-assembly, but require external control in macroscopic mechanical systems, provided by, e.g., actuators in robotics or manual folding in origami. Here we introduce shape-changing mechanical metamaterials, that exhibit self-guided multi-step pathways in response to global uniform compression. Their design combines strongly nonlinear mechanical elements with a multimodal architecture that allows for a sequence of topological reconfigurations, i.e., modifications of the topology caused by the formation of internal self-contacts. We realized such metamaterials by digital manufacturing, and show that the pathway and final configuration can be controlled by rational design of the nonlinear mechanical elements. We furthermore demonstrate that self-contacts suppress pathway errors. Finally, we demonstrate how hierarchical architectures allow to extend the number of distinct reconfiguration steps. Our work establishes general principles for designing mechanical pathways, opening new avenues for self-folding media, pluripotent materials, and pliable devices in, e.g., stretchable electronics and soft robotics.Comment: 16 pages, 3 main figures, 10 extended data figures. See https://youtu.be/8m1QfkMFL0I for an explanatory vide

    Exposure and impact of a mass media campaign targeting sexual health amongst Scottish men who have sex with men: an outcome evaluation

    Get PDF
    Background: This paper explores the exposure and impact of a Scottish mass media campaign: Make Your Position Clear. It ran from October 2009 to July 2010, targeted gay men and other men who have sex with men (MSM), and had two key aims: to promote regular sexual health and HIV testing every 6 months, and to promote the use of appropriate condoms and water-based lubricant with each episode of anal intercourse. Methods: A cross-sectional survey (anonymous and self-report) was conducted 10 months after the campaign was launched (July 2010). Men were recruited from commercial venues. Outcome measures included use of lubricant, testing for sexually transmitted infections and HIV, and intentions to seek HIV testing within the following six months. Linear-by-linear chi-square analysis and binary logistic regressions were conducted to explore the associations between the outcome measures and campaign exposure. Results: The total sample was 822 men (62.6% response rate). Men self-identifying as HIV positive were excluded from the analysis (n = 38). Binary logistic analysis indicated that those with mid or high campaign exposure were more likely to have been tested for HIV in the previous six months when adjusted for age, area of residence and use of the “gay scene” (AOR = 1.96, 95% CI = 1.26 to 3.06, p = .003), but were not more likely to be tested for STIs (AOR = 1.37, 95% CI = 0.88 to 2.16, p = .167). When adjusted for previous HIV testing, those with mid or high campaign exposure were not more likely to indicate intention to be tested for HIV in the following six months (AOR = 1.30, 95% CI = 0.73 to 2.32, p = .367). Those with no campaign exposure were less likely than those with low exposure to have used appropriate lubricant with anal sex partners in the previous year (AOR = 0.42, 95% CI = 0.23 to 0.77, p = .005). Conclusions: The campaign had demonstrable reach. The analysis showed partial support for the role of mass media campaigns in improving sexual health outcomes. This suggests that a role for mass media campaigns remains within combination HIV prevention

    Beating the channel capacity limit for linear photonic superdense coding

    Full text link
    Dense coding is arguably the protocol that launched the field of quantum communication. Today, however, more than a decade after its initial experimental realization, the channel capacity remains fundamentally limited as conceived for photons using linear elements. Bob can only send to Alice three of four potential messages owing to the impossibility of carrying out the deterministic discrimination of all four Bell states with linear optics, reducing the attainable channel capacity from 2 to log_2 3 \approx 1.585 bits. However, entanglement in an extra degree of freedom enables the complete and deterministic discrimination of all Bell states. Using pairs of photons simultaneously entangled in spin and orbital angular momentum, we demonstrate the quantum advantage of the ancillary entanglement. In particular, we describe a dense-coding experiment with the largest reported channel capacity and, to our knowledge, the first to break the conventional linear-optics threshold. Our encoding is suited for quantum communication without alignment and satellite communication.Comment: Letter: 6 pages, 4 figures. Supplementary Information: 4 pages, 1 figur

    More Benefits of Semileptonic Rare B Decays at Low Recoil: CP Violation

    Full text link
    We present a systematic analysis of the angular distribution of Bbar -> Kbar^\ast (-> Kbar pi) l^+ l^- decays with l = e, mu in the low recoil region (i.e. at high dilepton invariant masses of the order of the mass of the b-quark) to account model-independently for CP violation beyond the Standard Model, working to next-to-leading order QCD. From the employed heavy quark effective theory framework we identify the key CP observables with reduced hadronic uncertainties. Since some of the CP asymmetries are CP-odd they can be measured without B-flavour tagging. This is particularly beneficial for Bbar_s,B_s -> phi(-> K^+ K^-) l^+ l^- decays, which are not self-tagging, and we work out the corresponding time-integrated CP asymmetries. Presently available experimental constraints allow the proposed CP asymmetries to be sizeable, up to values of the order ~ 0.2, while the corresponding Standard Model values receive a strong parametric suppression at the level of O(10^-4). Furthermore, we work out the allowed ranges of the short-distance (Wilson) coefficients C_9,C_10 in the presence of CP violation beyond the Standard Model but no further Dirac structures. We find the Bbar_s -> mu^+ mu^- branching ratio to be below 9*10^-9 (at 95% CL). Possibilities to check the performance of the theoretical low recoil framework are pointed out.Comment: 18 pages, 3 fig.; 1 reference and comment on higher order effects added; EOS link fixed. Minor adjustments to Eqs 4.1-4.3 to match the (lower) q^2-cut as given in paper. Main results and conclusions unchanged; v3+v4: treatment of exp. uncert. in likelihood-function in EOS fixed and constraints from scan on C9,C10 updated (Fig 2,3 and Eqs 3.2,3.3). Main results and conclusions absolutely unchange

    Rare B Decays with a HyperCP Particle of Spin One

    Full text link
    In light of recent experimental information from the CLEO, BaBar, KTeV, and Belle collaborations, we investigate some consequences of the possibility that a light spin-one particle is responsible for the three Sigma^+ -> p mu^+ mu^- events observed by the HyperCP experiment. In particular, allowing the new particle to have both vector and axial-vector couplings to ordinary fermions, we systematically study its contributions to various processes involving b-flavored mesons, including B-Bbar mixing as well as leptonic, inclusive, and exclusive B decays. Using the latest experimental data, we extract bounds on its couplings and subsequently estimate upper limits for the branching ratios of a number of B decays with the new particle. This can serve to guide experimental searches for the particle in order to help confirm or refute its existence.Comment: 17 pages, 3 figures; discussion on spin-0 case modified, few errors corrected, main conclusions unchange

    Demon-like Algorithmic Quantum Cooling and its Realization with Quantum Optics

    Get PDF
    The simulation of low-temperature properties of many-body systems remains one of the major challenges in theoretical and experimental quantum information science. We present, and demonstrate experimentally, a universal cooling method which is applicable to any physical system that can be simulated by a quantum computer. This method allows us to distill and eliminate hot components of quantum states, i.e., a quantum Maxwell's demon. The experimental implementation is realized with a quantum-optical network, and the results are in full agreement with theoretical predictions (with fidelity higher than 0.978). These results open a new path for simulating low-temperature properties of physical and chemical systems that are intractable with classical methods.Comment: 7 pages, 5 figures, plus supplementarity material
    corecore