Post-Selection Inference for Generalized Linear Models with Many Controls

This paper considers generalized linear models in the presence of many controls. We lay out a general methodology to estimate an effect of interest based on the construction of an instrument that immunize against model selection mistakes and apply it to the case of logistic binary choice model. More specifically we propose new methods for estimating and constructing confidence regions for a regression parameter of primary interest $\alpha_0$, a parameter in front of the regressor of interest, such as the treatment variable or a policy variable. These methods allow to estimate $\alpha_0$ at the root-$n$ rate when the total number $p$ of other regressors, called controls, potentially exceed the sample size $n$ using sparsity assumptions. The sparsity assumption means that there is a subset of $s<n$ controls which suffices to accurately approximate the nuisance part of the regression function. Importantly, the estimators and these resulting confidence regions are valid uniformly over $s$-sparse models satisfying $s^2\log^2 p = o(n)$ and other technical conditions. These procedures do not rely on traditional consistent model selection arguments for their validity. In fact, they are robust with respect to moderate model selection mistakes in variable selection. Under suitable conditions, the estimators are semi-parametrically efficient in the sense of attaining the semi-parametric efficiency bounds for the class of models in this paper

Phase soliton and pairing symmetry of a two-band superconductor: Role of the proximity effect

We suggest a mechanism which promotes the existence of a phase soliton -- topological defect formed in the relative phase of superconducting gaps of a two-band superconductor with s+- type of pairing. This mechanism exploits the proximity effect with a conventional s-wave superconductor which favors the alignment of the phases of the two-band superconductor which, in the case of s+- pairing, are pi-shifted in the absence of proximity. In the case of a strong proximity such effect can be used to reduce soliton's energy below the energy of a soliton-free state thus making the soliton thermodynamically stable. Based on this observation we consider an experimental setup, applicable both for stable and metastable solitons, which can be used to distinguish between s+- and s++ types of pairing in the iron-based multiband superconductors.Comment: New references, added discussion about self-consistency of the GL description of a phase soliton in the presence of a proximity patc

Role of metal-dependent regulation of ESX-3 secretion in intracellular survival of Mycobacterium tuberculosis

More people die every year from Mycobacterium tuberculosis infection than from infection by any other bacterial pathogen. Type VII secretion systems (T7SS) are used by both environmental and pathogenic mycobacteria to secrete proteins across their complex cell envelope. In the nonpathogen Mycobacterium smegmatis, the ESX-1 T7SS plays a role in conjugation, and the ESX-3 T7SS is involved in metal homeostasis. In M. tuberculosis, these secretion systems have taken on roles in virulence, and they also are targets of the host immune response. ESX-3 secretes a heterodimer composed of EsxG (TB9.8) and EsxH (TB10.4), which impairs phagosome maturation in macrophages and is essential for virulence in mice. Given the importance of EsxG and EsxH during infection, we examined their regulation. With M. tuberculosis, the secretion of EsxG and EsxH was regulated in response to iron and zinc, in accordance with the previously described transcriptional response of the esx-3 locus to these metals. While iron regulated the esx-3 expression in both M. tuberculosis and M. smegmatis, there is a significant difference in the dynamics of this regulation. In M. smegmatis, the esx-3 locus behaved like other iron-regulated genes such as mbtB. In M. tuberculosis, both iron and zinc modestly repressed esx-3 expression. Diminished secretion of EsxG and EsxH in response to these metals altered the interaction of M. tuberculosis with macrophages, leading to impaired intracellular M. tuberculosis survival. Our findings detail the regulatory differences of esx-3 in M. tuberculosis and M. smegmatis and demonstrate the importance of metal-dependent regulation of ESX-3 for virulence in M. tuberculosis

Optical emissions associated with energetic electrons produced by stepping leaders in cloud-to-ground lightning discharges

All data used in this paper are directly available after a request is made to authors W.X. ([email protected]), S.C. ([email protected]), or V.P.P. ([email protected]).International audienceBoth natural cloud-to-ground and rocket-triggered lightning flashes have been found to be associated with intense and brief bursts of X-ray emissions. Using a full energy Monte Carlo model combined with an optical emission model, we quantify the optical emissions induced by the strong acceleration of thermal runaway electrons in the highly inhomogeneous electric field produced by stepping lightning leaders. The results demonstrate that this acceleration process is accompanied with not only high-energy X-ray emissions but also detectable levels of optical emissions. The fluorescence beam exhibits a conical shape and appears to be larger than the streamer zone associated with the lightning leader. Moreover, we emphasize that the size of the fluorescence beam largely depends on the electrical properties of the associated lightning leader and the intensity ratio between emissions from the second positive band system of N 2 and the first negative band system of N + 2 reflects the intrinsic difference in the energetics of electrons involved. Therefore, corresponding measurements compared to modeling results can provide useful information for understanding of the stepping mechanism of lightning leaders and associated X-ray production processes

Spin Seebeck effect from antiferromagnetic magnons and critical spin fluctuations in epitaxial FeF2 films

We report a longitudinal spin Seebeck effect (SSE) study in epitaxially grown FeF2(110) antiferromagnetic (AFM) thin films with strong uniaxial anisotropy over the temperature range of 3.8 - 250 K. Both the magnetic field- and temperature-dependent SSE signals below the N\'eel temperature (TN=70 K) of the FeF2 films are consistent with a theoretical model based on the excitations of AFM magnons without any net induced static magnetic moment. In addition to the characteristic low-temperature SSE peak associated with the AFM magnons, there is another SSE peak at TN which extends well into the paramagnetic phase. All the SSE data taken at different magnetic fields up to 12 T near and above the critical point TN follow the critical scaling law very well with the critical exponents for magnetic susceptibility of 3D Ising systems, which suggests that the AFM spin correlation is responsible for the observed SSE near TN

3d Printed Multilayer Microwave Absorber

This paper explores the possibility to create 3D printed multilayer electromagnetic absorbers. The proposed design is similar to the thin-film filters used in optics and consists of interleaving high and low permittivity layers. Based on transmission line theory, the multilayer absorber can be designed in a circuit simulator. Analytical equations, circuit simulations, and measurements are used to analyze and validate the designed absorber. Multilayer absorbers based on 3D printed material can be an inexpensive option for engineering usage with great design flexibility and fast fabrication