Specific Involvement of G Proteins in Regulation of Serum Response Factor-mediated Gene Transcription by Different Receptors

Regulation of serum response factor (SRF)-mediated gene transcription by G protein subunits and G protein-coupled receptors was investigated in transfected NIH3T3 cells and in a cell line that was derived from mice lacking G_(αq) and G_(α11). We found that the constitutively active forms of the α subunits of the G_q and G_(12) class of G proteins, including Gα_q, Gα_(11), Gα_(14), Gα_(16), Gα_(12), and Gα_(13), can activate SRF in NIH3T3 cells. We also found that the type 1 muscarinic receptor (m1R) and α_1-adrenergic receptor (AR)-mediated SRF activation is exclusively dependent on Gα_(q/11), while the receptors for thrombin, lysophosphatidic acid (LPA), thromboxane A2, and endothelin can activate SRF in the absence of Gα_(q/11). Moreover, RGS12 but not RGS2, RGS4, or Axin was able to inhibit Gα_(12) and Gα_(13)-mediated SRF activation. And RGS12, but not other RGS proteins, blocked thrombin- and LPA-mediated SRF activation in the Gα_(q/11)-deficient cells. Therefore, the thrombin, LPA, thromboxane A2, and endothelin receptors may be able to couple to Gα_(12/13). On the contrary, receptors including β_2- and α_2-ARs, m2R, the dopamine receptors type 1 and 2, angiotensin receptors types 1 and 2, and interleukin-8 receptor could not activate SRF in the presence or absence of Gα_(q/11), suggesting that these receptors cannot couple to endogenous G proteins of the G_(12) or G_q classes

Stochastic equations with low regularity drifts

By using the It\^{o}-Tanaka trick, we prove the unique strong solvability as well as the gradient estimates for stochastic differential equations with irregular drifts in low regularity Lebesgue-H\"{o}lder space $L^q(0,T;{\mathcal C}_b^\alpha({\mathbb R}^d))$ with $\alpha\in(0,1)$ and $q\in (2/(1+\alpha),2$). As applications, we show the unique weak and strong solvability for stochastic transport equations driven by the low regularity drift with $q\in (4/(2+\alpha),2$) as well as the local Lipschitz estimate for stochastic strong solutions

Advances in stabilisation of hybrid stochastic differential equations by delay feedback control

A novel approach to design the feedback control based on past states is proposed for hybrid stochastic differential equations (HSDEs). This new theorem builds up the connection between the delay feedback control and the control function without delay terms, which enables one to construct the delay feedback control using the existing results on stabilities of HSDEs. Methods to find the upper bound of the length of the time delay are also investigated. Numerical simulations are presented to demonstrate the new theorem

Improving Knowledge-aware Dialogue Generation via Knowledge Base Question Answering

Neural network models usually suffer from the challenge of incorporating commonsense knowledge into the open-domain dialogue systems. In this paper, we propose a novel knowledge-aware dialogue generation model (called TransDG), which transfers question representation and knowledge matching abilities from knowledge base question answering (KBQA) task to facilitate the utterance understanding and factual knowledge selection for dialogue generation. In addition, we propose a response guiding attention and a multi-step decoding strategy to steer our model to focus on relevant features for response generation. Experiments on two benchmark datasets demonstrate that our model has robust superiority over compared methods in generating informative and fluent dialogues. Our code is available at https://github.com/siat-nlp/TransDG.Comment: Accepted by AAAI-202

Proto-Tethys magmatic evolution along northern Gondwana: Insights from Late Silurian–Middle Devonian A-type magmatism, East Kunlun Orogen, Northern Tibetan Plateau, China

The East Kunlun Orogen records the geological evolutions of the Neoproterozoic – Early Paleozoic Proto-Tethyan Ocean and Late Paleozoic–Mesozoic Paleo-Tethys Ocean along northern Gondwana. However, the late-stage evolution of the Proto-Tethyan Ocean and the configuration of peri-Gondwana microcontinents during the Silurian – Devonian is under debate. Here we report new geochronological and geochemical data of A-type granites from the western Wulonggou and the eastern Gouli areas in the East Kunlun Orogen to deepen our understanding of these problems. Zircon LA-ICP-MS UPb data reveal that the Danshuigou monzogranite and Shenshuitan syenogranite from the western Wulonggou area were emplaced simultaneously at 418 ± 3 Ma, while the Niantang syenogranite from the eastern Gouli area was emplaced at 403 ± 2 Ma. All these rocks display high-K calcic-alkalic to shoshonitic and metaluminous to slight peraluminous signatures, with relatively low CaO, Al2O3, MgO and Sr, and high FeOt/MgO, Ga/Al, Zr, and Nb, indicating their A-type affinity. Their moderate whole-rock εNd(t) (−5.3 to −0.6) and zircon εHf(t) (−6.3–6.4) are different from those of depleted mantle and old basement rocks, but similar to those of the Ordovician–Silurian granitoids in the East Kunlun Orogen. These chemical signatures, together with the anhydrous, low-pressure and high-temperature characteristics of the magmas, indicate that partial melting of the Ordovician–Silurian granitoids generated these A-type granites. Regionally, these A-type granites and previously reported A-type granites in the East Kunlun Orogen compose a Late Silurian – Middle Devonian A-type granite belt. This belt, together with the regionally coeval molasse formation and mafic-ultramafic rocks, indicate a post-collisional extensional regime for the East Kunlun Orogen during the Late Silurian – Middle Devonian. Given that extensive contemporaneous post-collision-related magmatic rocks have also been revealed in the neighboring West Kunlun, Altyn, Qilian and Qinling blocks/terranes, we contend that the Neoproterozoic – Early Paleozoic Proto-Tethyan Ocean that separated these blocks/terranes from Gondwana had closed by the Late Silurian – Middle Devonian, which]resulted in the re-welding of the above blocks/terranes to northern Gondwana or Gondwana-derived microcontinents

Genesis of the Wutuogou Ag-Pb-Zn deposit in the Eastern Kunlun Orogenic Belt, NW China: Constraints from calcite U-Pb geochronology, mineral chemistry, and in-situ sulfur isotopes

The Wutuogou Ag-Pb-Zn deposit, a newly discovered vein-type deposit, is located in the Eastern Kunlun Orogenic Belt (EKOB), northwestern China. The vein-type Ag-Pb-Zn ore bodies are hosted in Middle Triassic granodiorite and monzogranite and are characterized by high-grade Ag, Pb, and Zn (average Ag: 293 g/t, Pb: 3.00 %, Zn: 2.85 %). Three paragenetic stages have been recognized: quartz + pyrite (Py-1) + arsenopyrite (stage I), pyrite (Py-2) + sphalerite + chalcopyrite + tetrahedrite + quartz (substage II-1), galena + pyrargyrite + freibergite + freieslebenite + quartz + calcite (substage II-2), and quartz + calcite (stage III). Except for Ag-bearing minerals (pyrargyrite, freibergite, and freieslebenite), invisible silver is also present in pyrite (1.91–165 ppm), sphalerite (3.86–8806 ppm), and galena (up to 0.21 wt%). The calcite is closely associated with sulfides in substage II-2 and yields a U-Pb age of 210 ± 7 Ma (MSWD = 2.7), which represents the ore-forming age (lower limit). Py-1 displays higher As contents and lower Co contents than those of Py-2, indicating a decrease in temperature from stage I to stage II. In addition, the Fe/Zn mass ratios (0.025–0.075) of sphalerite estimate the fluid temperature for substage II-1 of 246–284 ◦C, whereas the Ag/(Ag + Cu) and Zn/(Zn + Fe) mole ratios of freibergite estimate the fluid temperature for substage II-2 of 140–270 ◦C, further indicating the decrease of temperature from stage I through substage II-1 to substage II-2. Mineral assemblages of pyrite-chalcopyrite-tetrahedrite in substage II-1 and Ag-sulfosalts in substage II-2 suggest a decrease in sulfur fugacity (fS2). Both the decrease in fS2 and cooling of the mineralizing fluids facilitate silver precipitation. The heterogeneous compositions of the freibergite and the Ag zonation in sphalerite (Sp-1) resulted from retrograde solid-state reactions that redistributed Ag through microscale exsolution. The δ34S values (+5.49 to +7.78 ‰) of the sulfides and the low Zn/Cd ratios (107–195) of sphalerite indicate a felsic magma source for the ore-forming materials. Therefore, we concluded that the Wutuogou Ag-Pb-Zn deposit corresponds to a medium- to low-temperature magmatic-hydrothermal deposit associated with Late Triassic magmatism in the Eastern Kunlun Orogenic Belt (EKOB)Genesis of the Wutuogou Ag-Pb-Zn deposit in the Eastern Kunlun Orogenic Belt, NW China: Constraints from calcite U-Pb geochronology, mineral chemistry, and in-situ sulfur isotopespublishedVersio