1,633 research outputs found
Interface steps in field effect devices
The charge doped into a semiconductor in a field effect transistor (FET) is
generally confined to the interface of the semiconductor. A planar step at the
interface causes a potential drop due to the strong electric field of the FET,
which in turn is screened by the doped carriers. We analyze the dipolar
electronic structure of a single step in the Thomas-Fermi approximation and
find that the transmission coefficient through the step is exponentially
suppressed by the electric field and the induced carrier density as well as by
the step height. In addition, the field enhancement at the step edge can
facilitate the electric breakthrough of the insulating layer. We suggest that
these two effects may lead to severe problems when engineering FET devices with
very high doping. On the other hand steps can give rise to interesting physics
in superconducting FETs by forming weak links and potentially creating atomic
size Josephson junctions.Comment: 6 pages, 4 figures, submitted to J. Appl. Phy
Effects of street traffic noise in the night
The relationship between automobile traffic noise and the degree of disturbance experience experienced at night was explored through a random sample survey of 1600 individuals in rural and urban areas. The data obtained were used to establish threshold values
When it Pays to Rush: Interpreting Morphogen Gradients Prior to Steady-State
During development, morphogen gradients precisely determine the position of
gene expression boundaries despite the inevitable presence of fluctuations.
Recent experiments suggest that some morphogen gradients may be interpreted
prior to reaching steady-state. Theoretical work has predicted that such
systems will be more robust to embryo-to-embryo fluctuations. By analysing two
experimentally motivated models of morphogen gradient formation, we investigate
the positional precision of gene expression boundaries determined by
pre-steady-state morphogen gradients in the presence of embryo-to-embryo
fluctuations, internal biochemical noise and variations in the timing of
morphogen measurement. Morphogens that are direct transcription factors are
found to be particularly sensitive to internal noise when interpreted prior to
steady-state, disadvantaging early measurement, even in the presence of large
embryo-to-embryo fluctuations. Morphogens interpreted by cell-surface receptors
can be measured prior to steady-state without significant decrease in
positional precision provided fluctuations in the timing of measurement are
small. Applying our results to experiment, we predict that Bicoid, a
transcription factor morphogen in Drosophila, is unlikely to be interpreted
prior to reaching steady-state. We also predict that Activin in Xenopus and
Nodal in zebrafish, morphogens interpreted by cell-surface receptors, can be
decoded in pre-steady-state.Comment: 18 pages, 3 figure
The Fate of Trace Pollutants in Natural Waters – Lakes as 'Real-World Test Tubes'
Lakes play an important role as ecosystems and drinking-water supplies, but they are also ideal 'real-world test tubes' for studying the fate and behavior of trace pollutants in natural waters. The trace metals Cu, Zn, and Cd and the organic herbicide atrazine are used to illustrate
the combined approach of field measurements and mathematical modeling to assess the behavior of pollutants in natural waters. In contrast to fast flowing waters (i.e., rivers), lakes act as integrators of pollutant inputs from surface waters of the respective catchment area, thus being
regional indicators of human activities
Effect of the Matrix Metalloproteinase Inhibitor Doxycycline on Human Trace Fear Memory
Learning to predict threat is of adaptive importance, but aversive memory can also become disadvantageous and burdensome in clinical conditions such as posttraumatic stress disorder (PTSD). Pavlovian fear conditioning is a laboratory model of aversive memory and thought to rely on structural synaptic reconfiguration involving matrix metalloproteinase (MMP)9 signaling. It has recently been suggested that the MMP9-inhibiting antibiotic doxycycline, applied before acquisition training in humans, reduces fear memory retention after one week. This previous study used cued delay fear conditioning, in which predictors and outcomes overlap in time. However, temporal separation of predictors and outcomes is common in clinical conditions. Learning the association of temporally separated events requires a partly different neural circuitry, for which the role of MMP9 signaling is not yet known. Here, we investigate the impact of doxycycline on long-interval (15 s) trace fear conditioning in a randomized controlled trial with 101 (50 females) human participants. We find no impact of the drug in our preregistered analyses. Exploratorypost hocanalyses of memory retention suggested a serum level-dependent effect of doxycycline on trace fear memory retention. However, effect size to distinguish CS+/CS− in the placebo group turned out to be smaller than in previously used delay fear conditioning protocols, which limits the power of statistical tests. Our results suggest that doxycycline effect on trace fear conditioning in healthy individuals is smaller and less robust than anticipated, potentially limiting its clinical application potential
Silicon-organic hybrid electro-optical devices
Organic materials combined with strongly guiding silicon waveguides open the route to highly efficient electro-optical devices. Modulators based on the so-called silicon-organic hybrid (SOH) platform have only recently shown frequency responses up to 100 GHz, high-speed operation beyond 112 Gbit/s with fJ/bit power consumption. In this paper, we review the SOH platform and discuss important devices such as Mach-Zehnder and IQ-modulators based on the linear electro-optic effect. We further show liquid-crystal phase-shifters with a voltage-length product as low as V pi L = 0.06 V.mm and sub-mu W power consumption as required for slow optical switching or tuning optical filters and devices
Optical interconnect solution with plasmonic modulator and Ge photodetector array
We report on an optical chip-to-chip interconnect solution, thereby demonstrating plasmonics as a solution for ultra-dense, high-speed short-reach communications. The interconnect comprises a densely integrated plasmonic Mach-Zehnder modulator array that is packaged with standard driving electronics. On the receiver side, a germanium photodetector array is integrated with trans-impedance amplifiers. A multicore fiber provides a compact optical interface to the array. We demonstrate 4 × 20 Gb/s on-off keying signaling with direct detection.ISSN:1041-1135ISSN:1941-017
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