Are Asians comfortable with discussing death in health valuation studies? A study in multi-ethnic Singapore

BACKGROUND To characterize ease in discussing death (EID) and its influence on health valuation in a multi-ethnic Asian population and to determine the acceptability of various descriptors of death and "pits"/"all-worst" in health valuation. METHODS In-depth interviews (English or mother-tongue) among adult Chinese, Malay and Indian Singaporeans selected to represent both genders and a wide range of ages/educational levels. Subjects rated using 0–10 visual analogue scales (VAS): (1) EID, (2) acceptability of 8 descriptors for death, and (3) appropriateness of "pits" and "all-worst" as descriptors for the worst possible health state. Subjects also valued 3 health states using VAS followed by time trade-off (TTO). The influence of sociocultural variables on EID and these descriptors was studied using univariable analyses and multiple linear regression (MLR). The influence of EID on VAS/TTO utilities with adjustment for sociocultural variables was assessed using MLR. RESULTS Subjects (n = 63, 35% Chinese, 32% Malay, median age 44 years) were generally comfortable with discussing death (median EID: 8.0). Only education significantly influenced EID (p = 0.045). EID correlated weakly with VAS/TTO scores (range: VAS: -0.23 to 0.07; TTO: -0.14 to 0.11). All subjects felt "passed away", "departed" and "deceased" were most acceptable (median acceptability: 8.0) while "sudden death" and "immediate death" were least acceptable (median acceptability: 5.0). Subjects clearly preferred "all-worst" to "pits" (63% vs. 19%, p < 0.001). CONCLUSION Singaporeans were generally comfortable with discussing death and had clear preferences for several descriptors of death and for "all-worst". EID is unlikely to influence health preference measurement in health valuation studies

Structural and electronic properties of Al nanowires: an ab initio pseudopotential study

The stability and electronic structure of a single monatomic Al wire has been studied using the ab initio pseudopotential method. The Al wire undergoes two structural rearrangements under compression, i.e., zigzag configurations at angles of $140^o$ and $60^o$. The evolution of electronic structures of the Al chain as a function of structural phase transition has been investigated. The relationship between electronic structure and geometric stability is also discussed. The 2p bands in the Al nanowire are shown to play a critical role in its stability. The effects of density functionals (GGA and LDA) on cohesive energy and bond length of Al nanostructures (dimmer, chains, and monolayers) are also examined. The link between low dimensional 0D structure (dimmer) to high dimensional 3D bulk Al is estimated. An example of optimized tip-suspended finite atomic chain is presented to bridge the gap between hypothetical infinite chains and experimental finite chains.Comment: 11 pages, 5 figure

Prolonged operative time increases risk of blood loss and transfusion requirements in revision hip surgery.

INTRODUCTION: Revision hip surgery is well documented to have a high association with substantial blood loss and the associated need for a blood transfusion. This exposes the patient to increased risk of transfusion reaction and blood borne infection. There are many strategies to minimize allogeneic transfusion rates in revision surgery such as pre-operative autologous donation, peri-operative tranexamic acid, thrombin sealants, normovolaemic haemodilution, intra-operative blood salvage and the use of post-operative autologous drains. PATIENTS AND METHODS: We prospectively looked at 177 consecutive cases performed at one centre by a single surgical and anaesthetic team to identify which patient and operative factors were most significant in minimizing the requirement for an allogeneic blood transfusion. RESULTS: Our results identified the duration of surgery as being the only significant variable affecting the level of blood loss. We noted a 3% increase in the probability of massive blood loss (> 2000 mls) for every minute of increased surgical time in our series. CONCLUSIONS: We conclude that measures to minimize the duration of surgery would be beneficial in reducing blood loss and the risks of requiring blood transfusions in revision hip surgery

One-dimensional collision carts computer model and its design ideas for productive experiential learning

We develop an Easy Java Simulation (EJS) model for students to experience the physics of idealized one-dimensional collision carts. The physics model is described and simulated by both continuous dynamics and discrete transition during collision. In the field of designing computer simulations, we discuss briefly three pedagogical considerations such as 1) consistent simulation world view with pen paper representation, 2) data table, scientific graphs and symbolic mathematical representations for ease of data collection and multiple representational visualizations and 3) game for simple concept testing that can further support learning. We also suggest using physical world setup to be augmented complimentary with simulation while highlighting three advantages of real collision carts equipment like tacit 3D experience, random errors in measurement and conceptual significance of conservation of momentum applied to just before and after collision. General feedback from the students has been relatively positive, and we hope teachers will find the simulation useful in their own classes. 2015 Resources added: http://iwant2study.org/ospsg/index.php/interactive-resources/physics/02-newtonian-mechanics/02-dynamics/46-one-dimension-collision-js-model http://iwant2study.org/ospsg/index.php/interactive-resources/physics/02-newtonian-mechanics/02-dynamics/195-elastic-collisionComment: 6 pages, 8 figures, 1 table, 1 L. K. Wee, Physics Education 47 (3), 301 (2012); ISSN 0031-912

Codon 249 mutation of the p53 gene is a rare event in hepatocellular carcinomas from ethnic Chinese in Singapore.

The present study characterised p53 mutations in 44 hepatocellular carcinomas (HCCs) from Chinese patients residing in a high-incidence area. Twelve point mutations (27%) were detected in tumour tissues using single-strand conformation polymorphism analysis followed by direct DNA sequencing. Remarkably, no mutations were observed at codon 249. This is in contrast to HCCs from other high HCC incidence areas with endemic aflatoxin exposures, in which codon 249 is a mutational hot spot. It is therefore suggested that risk factors other than dietary exposure to aflatoxin may contribute to the high HCC incidence in Singapore

Evaluation and Improvement of Procurement Process with Data Analytics

Abstract—Analytics can be applied in procurement to benefit organizations beyond just prevention and detection of fraud. This study aims to demonstrate how advanced data mining techniques such as text mining and cluster analysis can be used to improve visibility of procurement patterns and provide decision-makers with insight to develop more efficient sourcing strategies, in terms of cost and effort. A case study of an organization’s effort to improve its procurement process is presented in this paper. The findings from this study suggest that opportunities exist for organizations to aggregate common goods and services among the purchases made under and across different prescribed procurement approaches. It also suggests that these opportunities are more prevalent in purchases made by individual project teams rather than across multiple project teams. Keywords—procurement; text mining; clustering; data analytics; fraud detection I

Predictable arguments of knowledge

We initiate a formal investigation on the power of predictability for argument of knowledge systems for NP. Specifically, we consider private-coin argument systems where the answer of the prover can be predicted, given the private randomness of the verifier; we call such protocols Predictable Arguments of Knowledge (PAoK). Our study encompasses a full characterization of PAoK, showing that such arguments can be made extremely laconic, with the prover sending a single bit, and assumed to have only one round (i.e., two messages) of communication without loss of generality. We additionally explore PAoK satisfying additional properties (including zero-knowledge and the possibility of re-using the same challenge across multiple executions with the prover), present several constructions of PAoK relying on different cryptographic tools, and discuss applications to cryptography

Photovoltaic power system simulation for small industry area

In this paper, modeling and simulation of 1MW grid connected PV system is simulated using National Renewable Energy Laboratory's (NREL) HOMER software, and the optimum system is analyzed to see the economic feasibility of the system in a small industry area in Malacca, Malaysia. The system is expected to foresee reduced grid energy consumption. Emphasis is also placed on reduction of green house gases emission. HOMER will simulate the system and perform optimization of system according to the available usage data and the available renewable energy (sun radiation) data. The lifecycle and cost of each system modules will also affect the optimization duly. In addition, HOMER also performs optimizations according to different assumption of uncertain factors to gauge the effect of sensitivity list

Enhanced self-field critical current density of nano-composite YBa(2)Cu(3)O(7) thin films grown by pulsed-laser deposition

This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ EPLA, 2008.Enhanced self-field critical current density Jc of novel, high-temperature superconducting thin films is reported. Layers are deposited on (001) MgO substrates by laser ablation of YBa2Cu3O7−δ(Y-123) ceramics containing Y2Ba4CuMOx (M-2411, M=Ag, Nb, Ru, Zr) nano-particles. The Jc of films depends on the secondary-phase content of the ceramic targets, which was varied between 0 and 15 mol%. Composite layers (2 mol% of Ag-2411 and Nb-2411) exhibit Jc values at 77 K of up to 5.1 MA/cm2, which is 3 to 4 times higher than those observed in films deposited from phase pure Y-123 ceramics. Nb-2411 grows epitaxially in the composite layers and the estimated crystallite size is ~10 nm.The Austrian Science Fund, the Austrian Federal Ministry of Economics and Labour, the European Science Foundation and the Higher Education Commission of Pakistan