The Resurrection Body “According to the Scriptures,” Chapter Three

If we suppose Intelligence, with an organism answering in its characteristics merely to the properties of the ether, we have a being conforming very nearly, if not quite, to the notion the mystics had of the indwellers of the supersensual world. With bodies more dense than steel, though unamenable to earthly sight or touch, these creatures would see the fleshly forms as a shadowy garment, and a matter at large but as a film thinner than air which offered no bar to their passage. And, exempt from the laws of gravitation which hold prison bound the frame of clay, they might levitate at will, and with the swiftness of light transport themselves from planet to planet. From the sun’s flame they could take no harm and even the chill of absolute zero would leave their bodies unscathed

The zebrafish eye—a paradigm for investigating human ocular genetics

Although human epidemiological and genetic studies are essential to elucidate the aetiology of normal and aberrant ocular development, animal models have provided us with an understanding of the pathogenesis of multiple developmental ocular malformations. Zebrafish eye development displays in depth molecular complexity and stringent spatiotemporal regulation that incorporates developmental contributions of the surface ectoderm, neuroectoderm and head mesenchyme, similar to that seen in humans. For this reason, and due to its genetic tractability, external fertilisation, and early optical clarity, the zebrafish has become an invaluable vertebrate system to investigate human ocular development and disease. Recently, zebrafish have been at the leading edge of preclinical therapy development, with their amenability to genetic manipulation facilitating the generation of robust ocular disease models required for large-scale genetic and drug screening programmes. This review presents an overview of human and zebrafish ocular development, genetic methodologies employed for zebrafish mutagenesis, relevant models of ocular disease, and finally therapeutic approaches, which may have translational leads in the future.Eye advance online publication, 9 September 2016; doi:10.1038/eye.2016.198

Why general education?: Peters, Hirst and history

Richard Peters argued for a general education based largely on the study of truth-seeking subjects for its own sake. His arguments have long been acknowledged as problematic. There are also difficulties with Paul Hirst's arguments for a liberal education, which in part overlap with Peters'. Where justification fails, can historical explanation illuminate? Peters was influenced by the prevailing idea that a secondary education should be based on traditional, largely knowledge-orientated subjects, pursued for intrinsic as well as practical ends. Does history reveal good reasons for this view? The view itself has roots going back to the 16th century and the educational tradition of radical Protestantism. Religious arguments to do with restoring the image of an omniscient God in man made good sense, within their own terms, of an encyclopaedic approach to education. As these faded in prominence after 1800, old curricular patterns persisted in the drive for ‘middle-class schools’, and new, less plausible justifications grew in salience. These were based first on faculty psychology and later on the psychology of individual differences. The essay relates the views of Peters and Hirst to these historical arguments, asking how far their writings show traces of the religious argument mentioned, and how their views on education and the development of mind relate to the psychological arguments

A QSO survey via optical variability and zero proper motion in the M92 field. IV. More QSOs due to improved photometry

We continue the QSO search in the 10 square degrees Schmidt field around M92 based on variability and proper motion (VPM) constraints. We have re-reduced 162 digitised B plates with a time-baseline of more than three decades and have considerably improved both the photometric accuracy and the star-galaxy separation at B>19. QSO candidates are selected and marked with one out of three degrees of priority based on the statistical significance of their measured variability and zero proper motion. Spectroscopic follow-up observations of 84 new candidates with B>19 revealed an additional 37 QSOs and 7 Seyfert1s. In particular, all 92 high-priority candidates are spectroscopically classified now; among them are 70 QSOs and 9 Seyfert1s (success rate 86%). We expect that 87% (55%) of all QSOs with B<19.0 (19.8) are contained in this high-priority subsample. For the combined sample of high-priority and medium-priority objects, a completeness of 89% is estimated up to B_lim=19.5. The sample of all AGNs detected in the framework of the VPM search in the M92 field contains now 95 QSOs and 14 Seyfert1s with B<19.9. Although the VPM QSOs were selected by completely different criteria, their properties do not significantly differ from those of QSOs found by more traditional optical survey techniques. In particular, the spectra and the optical broad band colours do not provide any hints on a substantial population of red QSOs up to the present survey limit.Comment: 13 pages, 12 figures, accepted for publication in Astronomy and Astrophysic

Pharmacogenetic Testing for Clopidogrel Using the Rapid INFINITI Analyzer A Dose-Escalation Study

ObjectivesOur aim was to assess whether a higher clopidogrel maintenance dose has a greater antiplatelet effect in CYP2C19*2 allele carriers compared with noncarriers.BackgroundClopidogrel is a prodrug that is biotransformed by the cytochrome P450 enzymes CYP2C19, 2C9, and 3A4, 2B6, 1A2. The CYPC219*2 loss of function variant has been associated with a reduced antiplatelet response to clopidogrel and a 3-fold risk of stent thrombosis.MethodsForty patients on standard maintenance dosage clopidogrel (75 mg), for 9.4 ± 9.2 weeks, were enrolled into a dose escalation study. Platelet function was assessed at baseline and after 1 week of 150 mg once daily using the VerifyNow platelet function analyzer (Accumetrics Ltd., San Diego, California). Genomic DNA was hybridized to a BioFilmChip microarray on the INFINITI analyzer (AutoGenomics Inc., Carlsbad, California) and analyzed for the CYP19*2, *4, *17, and CYP2C9*2, *3 polymorphisms.ResultsPlatelet inhibition increased over 1 week, mean +8.6 ± 13.5% (p = 0.0003). Carriers of the CYP2C19*2 allele had significantly reduced platelet inhibition at baseline (median 18%, range 0% to 72%) compared with wildtype (wt) (median 59%, range 11% to 95%, p = 0.01) and at 1 week (p = 0.03). CYP2C19*2 allele carriers had an increase in platelet inhibition of (mean +9 ± 11%, p = 0.03) and reduction in platelet reactivity (mean −26 ± 38 platelet response unit, p = 0.04) with a higher dose. Together CYP2C19*2 and CYP2C9*3 loss of function carriers had a greater change in platelet inhibition with 150 mg daily than wt/wt (+10.9% vs. +0.7%, p = 0.04).ConclusionsIncreasing the dose of clopidogrel in patients with nonresponder polymorphisms can increase antiplatelet response. Personalizing clopidogrel dosing using pharmacogenomics may be an effective method of optimizing treatment

Statistics of dark matter haloes expected from weak lensing surveys

The distortion of the images of faint high-redshift galaxies can be used to probe the intervening mass distribution. This weak gravitational lensing effect has been used recently to study the (projected) mass distribution of several clusters at intermediate and high redshifts. In addition, the weak lensing effect can be employed to detect (dark) matter concentrations in the Universe, based on their mass properties alone. Thus it is feasible to obtain a mass-selected sample of `clusters', and thereby probe the full range of their mass-to-light ratios. We study the expected number density of such haloes which can be detected in ongoing and future deep wide-field imaging surveys, using the number density of haloes as predicted by the Press-Schechter theory, and modeling their mass profile by the `universal' density profile found by Navarro, Frenk & White. We find that in all cosmological models considered, the number density of haloes with a signal-to-noise ratio larger than 5 exceeds 10 per square degree. With the planned MEGACAM imaging survey of $\sim 25 deg^2$, it will be easily possible to distinguish between the most commonly discussed cosmological parameter sets.Comment: 8 pages, 7 figures, submitted to MNRA