12,556 research outputs found

    Planting on Rural School Grounds

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    Pharmacological activation of endogenous protective pathways against oxidative stress under conditions of sepsis

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    Funding The study was funded entirely by institutional funds.Peer reviewedPostprin

    Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis

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    Funding This study was funded by the Medical Research Council (Grant number G0800149). Research material from this study is not available. Acknowledgement We are very grateful to Dr Robin A.J. Smith, Department of Chemistry, University of Otago, Dunedin, New Zealand, for the generous gifts of MitoE and MitoQ, without which this work would not have been possible.Peer reviewedPublisher PD

    Development of novel multiplex microsatellite polymerase chain reactions to enable high-throughput population genetic studies of Schistosoma haematobium

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    © 2015 Webster et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. The attached file is the published version of the article

    Unravelling Active Galactic Nuclei

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    A complete flat-spectrum radio-loud sample of AGN includes a significant fraction of Seyfert-like AGN including a NLS1. Analysis of their optical spectra suggests that the reddest continuum colours are either associated with AGN in nearby resolved galaxies, or distant quasars showing relatively narrow permitted emission lines.Comment: Poster contribution presented at the Joint MPE,AIP,ESO workshop on NLS1s, Bad Honnef, Dec. 1999, to appear in New Astronomy Reviews; also available at http://wave.xray.mpe.mpg.de/conferences/nls1-worksho

    Prenatal Exposure to Tetrachloroethylene-Contaminated Drinking Water and the Risk of Congenital Anomalies: A Retrospective Cohort Study

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    BACKGROUND: Prior animal and human studies of prenatal exposure to solvents including tetrachloroethylene (PCE) have shown increases in the risk of certain congenital anomalies among exposed offspring. OBJECTIVES: This retrospective cohort study examined whether PCE contamination of public drinking water supplies in Massachusetts influenced the occurrence of congenital anomalies among children whose mothers were exposed around the time of conception. METHODS: The study included 1,658 children whose mothers were exposed to PCE-contaminated drinking water and a comparable group of 2,999 children of unexposed mothers. Mothers completed a self-administered questionnaire to gather information on all of their prior births, including the presence of anomalies, residential histories and confounding variables. PCE exposure was estimated using EPANET water distribution system modeling software that incorporated a fate and transport model. RESULTS: Children whose mothers had high exposure levels around the time of conception had an increased risk of congenital anomalies. The adjusted odds ratio of all anomalies combined among children with prenatal exposure in the uppermost quartile was 1.5 (95% CI: 0.9, 2.5). No meaningful increases in the risk were seen for lower exposure levels. Increases were also observed in the risk of neural tube defects (OR: 3.5, 95% CI: 0.8, 14.0) and oral clefts (OR 3.2, 95% CI: 0.7, 15.0) among offspring with any prenatal exposure. CONCLUSION: The results of this study suggest that the risk of certain congenital anomalies is increased among the offspring of women who were exposed to PCE-contaminated drinking water around the time of conception. Because these results are limited by the small number of children with congenital anomalies that were based on maternal reports, a follow-up investigation should be conducted with a larger number of affected children who are identified by independent records.National Institute of Environmental Health (5 P42 ES007381); National Institutes of Healt

    Comparing and characterizing some constructions of canonical bases from Coxeter systems

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    The Iwahori-Hecke algebra H\mathcal{H} of a Coxeter system (W,S)(W,S) has a "standard basis" indexed by the elements of WW and a "bar involution" given by a certain antilinear map. Together, these form an example of what Webster calls a pre-canonical structure, relative to which the well-known Kazhdan-Lusztig basis of H\mathcal{H} is a canonical basis. Lusztig and Vogan have defined a representation of a modified Iwahori-Hecke algebra on the free Z[v,v1]\mathbb{Z}[v,v^{-1}]-module generated by the set of twisted involutions in WW, and shown that this module has a unique pre-canonical structure satisfying a certain compatibility condition, which admits its own canonical basis which can be viewed as a generalization of the Kazhdan-Lusztig basis. One can modify the parameters defining Lusztig and Vogan's module to obtain other pre-canonical structures, each of which admits a unique canonical basis indexed by twisted involutions. We classify all of the pre-canonical structures which arise in this fashion, and explain the relationships between their resulting canonical bases. While some of these canonical bases are related in a trivial fashion to Lusztig and Vogan's construction, others appear to have no simple relation to what has been previously studied. Along the way, we also clarify the differences between Webster's notion of a canonical basis and the related concepts of an IC basis and a PP-kernel.Comment: 32 pages; v2: additional discussion of relationship between canonical bases, IC bases, and P-kernels; v3: minor revisions; v4: a few corrections and updated references, final versio
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