Planting on Rural School Grounds

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The Economics of Farm Animal Welfare

The number of ways that one can be nice or nasty to animals are legion. This article will consider only one very specific aspect of farm animal welfare, namely, those systems of intensive animal production in which the system itself, irrespective of the quality of the stockmanship within the system, appears to restrict the normal behavior of farm animals to an unacceptable degree. The systems that were considered by the House of Commons Select Committee on Agriculure (1981) include egg production from hens in battery cages, production of veal from calves deprived of solid food and isolated in wooden crates, and the most intensive aspects of pig production, namely, cages for weaners and stalls, with or without tethers, for dry sows

Pharmacological activation of endogenous protective pathways against oxidative stress under conditions of sepsis

Funding The study was funded entirely by institutional funds.Peer reviewedPostprin

Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis

Funding This study was funded by the Medical Research Council (Grant number G0800149). Research material from this study is not available. Acknowledgement We are very grateful to Dr Robin A.J. Smith, Department of Chemistry, University of Otago, Dunedin, New Zealand, for the generous gifts of MitoE and MitoQ, without which this work would not have been possible.Peer reviewedPublisher PD

Development of novel multiplex microsatellite polymerase chain reactions to enable high-throughput population genetic studies of Schistosoma haematobium

© 2015 Webster et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. The attached file is the published version of the article

Melatonin as a potential therapy for sepsis : a phase I dose escalation study and an ex vivo whole blood model under conditions of sepsis

This article is protected by copyright. All rights reserved. This study was funded by the Chief Scientist Office, NHS Scotland. We would like to thank all the volunteers who gave up their time and blood to take part in the study and the data monitoring committee and staff of the intensive care unit for their support. In addition, thanks to Dr Malachy Columb for performing Page's trend test for us and to Annette Fearnley at Nu-Pharm Ltd for her advice.Peer reviewedPublisher PD

Single-Cell Transcriptomes Reveal a Complex Cellular Landscape in the Middle Ear and Differential Capacities for Acute Response to Infection.

Single-cell transcriptomics was used to profile cells of the normal murine middle ear. Clustering analysis of 6770 transcriptomes identified 17 cell clusters corresponding to distinct cell types: five epithelial, three stromal, three lymphocyte, two monocyte, two endothelial, one pericyte and one melanocyte cluster. Within some clusters, cell subtypes were identified. While many corresponded to those cell types known from prior studies, several novel types or subtypes were noted. The results indicate unexpected cellular diversity within the resting middle ear mucosa. The resolution of uncomplicated, acute, otitis media is too rapid for cognate immunity to play a major role. Thus innate immunity is likely responsible for normal recovery from middle ear infection. The need for rapid response to pathogens suggests that innate immune genes may be constitutively expressed by middle ear cells. We therefore assessed expression of innate immune genes across all cell types, to evaluate potential for rapid responses to middle ear infection. Resident monocytes/macrophages expressed the most such genes, including pathogen receptors, cytokines, chemokines and chemokine receptors. Other cell types displayed distinct innate immune gene profiles. Epithelial cells preferentially expressed pathogen receptors, bactericidal peptides and mucins. Stromal and endothelial cells expressed pathogen receptors. Pericytes expressed pro-inflammatory cytokines. Lymphocytes expressed chemokine receptors and antimicrobials. The results suggest that tissue monocytes, including macrophages, are the master regulators of the immediate middle ear response to infection, but that virtually all cell types act in concert to mount a defense against pathogens

Comparing and characterizing some constructions of canonical bases from Coxeter systems

The Iwahori-Hecke algebra $\mathcal{H}$ of a Coxeter system $(W,S)$ has a "standard basis" indexed by the elements of $W$ and a "bar involution" given by a certain antilinear map. Together, these form an example of what Webster calls a pre-canonical structure, relative to which the well-known Kazhdan-Lusztig basis of $\mathcal{H}$ is a canonical basis. Lusztig and Vogan have defined a representation of a modified Iwahori-Hecke algebra on the free $\mathbb{Z}[v,v^{-1}]$-module generated by the set of twisted involutions in $W$, and shown that this module has a unique pre-canonical structure satisfying a certain compatibility condition, which admits its own canonical basis which can be viewed as a generalization of the Kazhdan-Lusztig basis. One can modify the parameters defining Lusztig and Vogan's module to obtain other pre-canonical structures, each of which admits a unique canonical basis indexed by twisted involutions. We classify all of the pre-canonical structures which arise in this fashion, and explain the relationships between their resulting canonical bases. While some of these canonical bases are related in a trivial fashion to Lusztig and Vogan's construction, others appear to have no simple relation to what has been previously studied. Along the way, we also clarify the differences between Webster's notion of a canonical basis and the related concepts of an IC basis and a $P$-kernel.Comment: 32 pages; v2: additional discussion of relationship between canonical bases, IC bases, and P-kernels; v3: minor revisions; v4: a few corrections and updated references, final versio