PERSISTENT POVERTY ACROSS THE RURAL-URBAN CONTINUUM

Persistent poverty is overwhelmingly rural and is very geographically concentrated. We have redefined the USDA ERS persistent poverty classification to include metropolitan counties meeting the 20 percent or higher poor criterion and we extend the time period through the 2000 Census. With this updated definition, there are 382 counties that have had poverty rates of 20 percent or more in each decennial census between 1960 and 2000. These persistent poverty counties are overwhelmingly rural (95 percent) and disproportionately rural (16 percent of nonmetro counties versus 2 percent of metro). The local economic environment in persistent poverty counties is much less favorable than in the nation as a whole. Per capita income is lower and unemployment rates higher in persistent poverty counties. Employment is more concentrated in services, extractive, construction/maintenance, and production/transportation occupations. Residents of persistent poverty counties tend to have lower education levels, and persistent poverty counties generally have larger shares of minority populations. The number of persistent poverty counties reduced considerably during the 1990s, but the "leavers" were disproportionately metropolitan, making persistent poverty increasingly a rural problem. Persistent poverty is overwhelmingly rural and it is very concentrated geographically. In this paper, we examine these striking regularities in U.S. economic geography, seeking to understand the causes and dynamics of poverty across the rural urban continuum. We also consider how alternative characterizations of "persistent poverty" and "rural and urban" might deepen our understanding of poverty and place. The paper has four sections. In the first, we examine how poverty and persistent poverty vary across the Rural Urban Continuum Codes and Urban Influence Codes developed by the USDA Economic Research Service (ERS). We start with the very useful "persistent poverty" classification developed by ERS that defines nonmetropolitan counties as persistent poverty counties if the poverty rate is 20 percent or higher in each decennial census between 1960 and 1990.We redefine persistent poverty to include metropolitan counties meeting the 20 percent or more poor criterion and we extend the time period through the 2000 Census. We also examine where poverty is concentrated in the United States and how persistent poverty varies across the new Core Based Statistical Area definitions for counties, developed recently by the Office of Management and Budget. In the second section, we examine how the demographic characteristics of the population vary across the rural-urban spectrum, comparing persistent poverty county demographics with those of all counties. The third section examines the dynamics of poverty and place. We examine the location, rurality and demographics of counties that escaped persistent poverty statues between 1990 and 2000, and how those characteristics compare to counties that remained in persistent poverty. We then identify the new entrants into high poverty since 1960. In the fourth section, we consider implications of reconceptualizing both "persistent poverty" and "rural and urban diversity". First, we explore the "persistent poverty" county classification, and how alternative definitions of persistent poverty counties might alter the conclusions one reaches about the geography of persistent poverty. We do this by exploring how defining persistent poverty with a different base year such as 1970 or 1980 affects the number of "persistent poverty" counties. We then explore what happens to "persistent poverty" if we raise the poverty threshold to 30 and 40 percent in defining persistent poverty counties. We then examine how conclusions about rural and urban persistent poverty change if one looks at poverty persistence in individual households rather than counties. Using PSID data, this analysis examines rates of persistent household poverty by looking at how the percent of households who remain in poverty for all 5 years during the 1993-98 period varies across central metro county to remote rural county continuum (an aggregation of Beale codes). Finally, we briefly explore how conclusions about the geography of poverty change if one divides metropolitan areas into "central city" and "suburb", and nonmetropolitan areas into "adjacent" and "nonadjacent."Food Security and Poverty,

Wittgenstein and Worship: Investigations of Liturgical Language-Games and Their Formative Role in Christian Identity

I argue that the Christian community’s religious language games, particularly liturgical action (theologia prima) and theological reflection (theologia secunda), mutually shape and correct one another. I demonstrate this using Wittgenstein’s philosophical method, adapting his approach to philosophy for theological use. The first part of this essay explains and demonstrates Wittgenstein’s philosophical method. The second part is an application of his method (with my own adaptation of this method for theology) with Christian liturgy as its subject. The third part of this essay discusses ways in which Wittgenstein’s approach might be adapted further in a fruitful way for theological reflection and catechesis

Molecular principles underlying dual RNA specificity in the Drosophila SNF protein

The first RNA recognition motif of the Drosophila SNF protein is an example of an RNA binding protein with multi-specificity. It binds different RNA hairpin loops in spliceosomal U1 or U2 small nuclear RNAs, and only in the latter case requires the auxiliary U2A′ protein. Here we investigate its functions by crystal structures of SNF alone and bound to U1 stem-loop II, U2A′ or U2 stem-loop IV and U2A′, SNF dynamics from NMR spectroscopy, and structure-guided mutagenesis in binding studies. We find that different loop-closing base pairs and a nucleotide exchange at the tips of the loops contribute to differential SNF affinity for the RNAs. U2A′ immobilizes SNF and RNA residues to restore U2 stem-loop IV binding affinity, while U1 stem-loop II binding does not require such adjustments. Our findings show how U2A′ can modulate RNA specificity of SNF without changing SNF conformation or relying on direct RNA contacts

Child anthropometry for restraint system design

Century Products, Los Angeles, Calif.Cosco/ Peterson, Columbus, Ind.Evenflo Juvenile Furniture Company, Piqua, OhioKolcraft Products, Chicago, Ill.Strolee of California, Comptonhttp://deepblue.lib.umich.edu/bitstream/2027.42/172/2/72118.0001.001.pd

Infant restraint usability follow-up

Insurance Institute for Highway Safety, Washington, D.C.http://deepblue.lib.umich.edu/bitstream/2027.42/335/2/46316.0001.001.pd

Elevated DDX21 regulates c-Jun activity and rRNA processing in human breast cancers

INTRODUCTION: The DDX21 RNA helicase has been shown to be a nucleolar and nuclear protein involved in ribosome RNA processing and AP-1 transcription. DDX21 is highly expressed in colon cancer, lymphomas, and some breast cancers, but little is known about how DDX21 might promote tumorigenesis. METHODS: Immunohistochemistry was performed on a breast cancer tissue array of 187 patients. In order to study the subcellular localization of DDX21 in both tumor tissue and tumor cell lines, indirect immunofluorescence was applied. The effect of DDX21 knockdown was measured by cellular apoptosis, rRNA processing assays, soft agar growth and mouse xenograft imaging. AP-1 transcriptional activity was analyzed with a luciferase reporter and bioluminescence imaging, as well as qRT-PCR analysis of downstream target, cyclin D1, to determine the mechanism of action for DDX21 in breast tumorigenesis. RESULTS: Herein, we show that DDX21 is highly expressed in breast cancer tissues and established cell lines. A significant number of mammary tumor tissues and established breast cancer cell lines exhibit nuclear but not nucleolar localization of DDX21. The protein expression level of DDX21 correlates with cell proliferation rate and is markedly induced by EGF signaling. Mechanistically, DDX21 is required for the phosphorylation of c-Jun on Ser73 and DDX21 deficiency markedly reduces the transcriptional activity of AP-1. Additionally, DDX21 promotes rRNA processing in multiple breast cancer cell lines. Tumor cells expressing high levels of endogenous DDX21 undergo apoptosis after acute DDX21 knockdown, resulting in significant reduction of tumorigenicity in vitro and in vivo. CONCLUSIONS: Our findings indicate that DDX21 expression in breast cancer cells can promote AP-1 activity and rRNA processing, and thus, promote tumorigenesis by two independent mechanisms. DDX21 could serve as a marker for a subset of breast cancer patients with higher proliferation potential and may be used as a therapeutic target for a subset of breast cancer patients. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13058-014-0449-z) contains supplementary material, which is available to authorized users

Lack of an Effect of Oral Iron Administration on Mycophenolic Acid Pharmacokinetics in Stable Renal Transplant Recipients

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90055/1/phco.27.9.1272.pd

Fostering Physics Content and Pedagogy Learning by Future Physics Teachers via Student Authored YouTube Video Projects

We describe a curricular innovation for STEM teacher preparation -- the use of video projects in undergraduate and graduate physics courses for future physics teachers at SUNY Buffalo State. US courses were adapted under the guidance of our colleagues’ similar work at Universität zu Köln [1]. Our students prepared end of course short “proof of concept” rough video vignettes of 5-10min addressing both physics content and physics pedagogical topics. YouTube [2] example videos are provided, and insights are shared

Adding Student Video Projects to Physics Courses

Physics students have traditionally prepared many kinds of reports—laboratory, activity, project, and even book or article reports. Smartphones and YouTube videos are familiar cultural objects to current students, and our students use smartphone cameras to include photographs of apparatus, phenomena, hand-sketched figures, graphs, and mathematical equations in their physics reports. Here we present basic techniques for physics students to use smartphones and tablets to create short (\u3c 5 min) end-of-semester video projects. Our students mainly use Apple Computer’s iPad1 tablets, but also other tablets and various smartphones. Finally we discuss appropriate instructor expectations and grading. Similar non-physics student video reporting efforts were reported using video cameras by Kearney,2 and Hechter and Guy.