Bulletin of the Jefferson Nurses\u27 Alumnae

Greetings to Alumnae Members Everywhere The Class Rooms - 1907-1935 Curtis Clinic Treasurer\u27s Report Commencement Week Jefferson Alumnae, 1893-1934 Lost Alumna

Ion Analysis at the Highest Stage - The Metrological Approach by National Metrological Institutes

Abstract.: National Metrological Institutes (NMI's) from fifteen different countries participated in interlaboratory comparisons where concentrations of about 1 g kg−1 in solutions of aluminium, copper, iron, magnesium, chloride and phosphate were measured. A very high comparability of the results irrespective of the analyte and the applied measurement technique was observed. The relative in-between laboratory standard deviations of the results as reported by the participating laboratories were between 0.13% for copper and chloride up to 0.33% for aluminium, and all of the 81 results were found in the range of ±1% with respect to the reference value. Due to the gravimetric preparation of the samples, a conventional true reference value was calculated, and no significant deviations of the reference values and the means of all results reported by the institutes were foun

Bees, farmers, tourists and hunters: conflict dynamics around Western Tanzania protected areas

Following important donor funding in Tanzania since the 1990s to support community based natural resource management, several cooperation agencies have implemented projects aiming at developing innovative conservation strategies combining protected and sustainable use areas. Based on data gathered in the Katavi Rukwa Lukwati and Ugalla core areas of Western Tanzania, this paper compares and analyses how projects developed their strategy and objectives to address conflicts between local population and conservation agents, and how this led to changes in conservation practices. The projects managed to achieve their objectives in conservation and poverty reduction at various degrees. Enhanced conflict resolution capacity involving private stakeholders, conservation agents and local communities, as well as improved collaboration between projects, helped to solve part of the conflicts. This was the case with the negotiation of rights of access for beekeepers to Rukwa game reserve. However, enduring sector based approaches continue to hinder opportunities for developing multiple use approaches. Contrasted results of the projects can be explained by factors inherent to projects' planning and management, but also by factors that are beyond projects' influence such as the historical and contemporary context in terms of governance of natural resources and more globally, of power relationships between the state, private organisations and the communitie

Alumnae Bulletin - Number 3

Greetings to Alumnae Members and Graduates Alumnae Officers Membership Financial Statement as of 3-1-37 Sick Committee Are You? Alumnae Days Were You at the Bazaar? History of the Nurses\u27 Relief Fund Forget-Me-Not In Memoriam Here and There Marriages Reported During 1936-1937 A Resume Student Nurse Activity Jefferson Nurses Choral Club The Bulletin - Publicity Committee Do You Know? Bazaar Accoun

Nurses\u27 Alumnae Association Bulletin - Volume 2 Number 1

March of Activities Treasurer\u27s Report It\u27s a Date Loyalty Coming Events Jefferson News In Florida for Winter The A.N.A. Convention Greetings! Keeping Up the Fight Eight Hour Committee Nurses Wanted Class of 1926 Convention Notes Attention Members Pine Street News Class of 1915 Class of 1916 Fifth Anniversary Prize Winners - 1932 Class of 1940 Owners of Scrap Books Sick List - 1939 and 1940 A Program of Nursing Information Please Private Duty Section Excerpts from Alumnae Minutes Staff News Please Remember Personals Engagements Marriages Deaths Hospital News Ballot for Officers Recent Births Lest You Forget! Please Change My Addres

Dopamine D2-receptor blockade enhances decoding of prefrontal signals in humans.

The prefrontal cortex houses representations critical for ongoing and future behavior expressed in the form of patterns of neural activity. Dopamine has long been suggested to play a key role in the integrity of such representations, with D2-receptor activation rendering them flexible but weak. However, it is currently unknown whether and how D2-receptor activation affects prefrontal representations in humans. In the current study, we use dopamine receptor-specific pharmacology and multivoxel pattern-based functional magnetic resonance imaging to test the hypothesis that blocking D2-receptor activation enhances prefrontal representations. Human subjects performed a simple reward prediction task after double-blind and placebo controlled administration of the D2-receptor antagonist amisulpride. Using a whole-brain searchlight decoding approach we show that D2-receptor blockade enhances decoding of reward signals in the medial orbitofrontal cortex. Examination of activity patterns suggests that amisulpride increases the separation of activity patterns related to reward versus no reward. Moreover, consistent with the cortical distribution of D2 receptors, post hoc analyses showed enhanced decoding of motor signals in motor cortex, but not of visual signals in visual cortex. These results suggest that D2-receptor blockade enhances content-specific representations in frontal cortex, presumably by a dopamine-mediated increase in pattern separation. These findings are in line with a dual-state model of prefrontal dopamine, and provide new insights into the potential mechanism of action of dopaminergic drugs.This work was supported by the Swiss National Science Foundation (grants PP00P1_128574, PP00P1_150739, and CRSII3_141965) and the Swiss National Centre of Competence in Research in Affective Sciences. The BCNI is supported by the Medical Research Council and Wellcome Trust. We acknowledge also the Neuroscience Center Zurich and thank M. Wälti and T. Baumgartner for help with data collection. T.W.R discloses consultancy with Lilly, Lundbeck, Teva, Otsuka, Shire Pharmaceuticals, ChemPartners, and Cambridge Cognition; and research grants with Lilly, Lundbeck, and GlaxoSmithKline. The remaining authors declare no competing financial interests.This is the final published version of the article. It was originally published in The Journal of Neuroscience (Kahnt T, Weber SC, Haker H, Robbins TW, Tobler PN,The Journal of Neuroscience 2015, 35(9), 4104-4111, doi: 10.1523/JNEUROSCI.4182-14.2015) http://dx.doi.org/10.1523/JNEUROSCI.4182-14.201

“This Graft-vs.-Host Disease Determines My Life. That's It.”—A Qualitative Analysis of the Experiences and Needs of Allogenic Hematopoietic Stem Cells Transplantation Survivors in Germany

Background: Allogeneic hematopoietic stem cell transplantation (alloHSCT) is the only curative treatment modality for many patients affected by hematologic malignancies. However, it can cause debilitating long-term effects. Understanding the impact of alloHSCT on all aspects of the patients' life is required for optimal survivorship management. Aim: To explore in-depth HSCT-survivors' experiences and needs post-transplant. Partners were included to provide further information on survivors' needs and how care could be improved in this area. Methods: We conducted semi-structured face-to-face and phone interviews with alloHSCT-survivors and their partners referred to a survivorship clinic in Germany. Theoretical sampling was used to recruit participants. Data were analyzed using framework analysis. Results: Thirty-two survivors (consent rate: 100%, response rate: 100%) and eighteen partners (consent rate: 84%, response rate: 72%) participated. Survivors were aged between 25 and 68 years (Median: 48, IQR: 25.3) and partners were aged between 26 and 64 years (Median: 54, IQR: 16, SD: 12.8). The themes emerging from the data involved survivors' needs included (i) the diversity of long-term treatment side-effects; and (ii) time post discharge as a dynamic process with individual peaks of burden. Survivors and their partners also suggested strategies for mitigating these unmet needs, i.e., (iii) transparent communication and patient empowerment; and (iv) improvement in continuity of care system and help with claiming social benefits as cornerstones of optimal survivorship care. Conclusion: To our knowledge, this is one of the first qualitative studies focused on the views of German alloHSCT-survivors on the long-term effects of alloHSCT and the first study integrating the view of their partners. Healthcare providers could better support survivors with managing their symptoms and adhering to their prescribed care by ensuring comprehensive, transparent communication that helps increase survivors' understanding and involvement in their care. Further efforts should be made to provide patient-centered, continuous survivorship care that involves additional support with navigating the healthcare and social service system. Intervention studies are required to test the effectiveness of the suggested strategies.Peer Reviewe

Towards systems metabolic engineering of streptomycetes for secondary metabolites production

Streptomycetes are known for their inherent ability to produce pharmaceutically relevant secondary metabolites. Discovery of medically useful, yet novel compounds has become a great challenge due to frequent rediscovery of known compounds and a consequent decline in the number of relevant clinical trials in the last decades. A paradigm shift took place when the first whole genome sequences of streptomycetes became available, from which silent or "cryptic" biosynthetic gene clusters (BGCs) were discovered. Cryptic BGCs reveal a so far untapped potential of the microorganisms for the production of novel compounds, which has spurred new efforts in understanding the complex regulation between primary and secondary metabolism. This new trend has been accompanied with development of new computational resources (genome and compound mining tools), generation of various high-quality omics data, establishment of molecular tools, and other strain engineering strategies. They all come together to enable systems metabolic engineering of streptomycetes, allowing more systematic and efficient strain development. In this review, the authors present recent progresses within systems metabolic engineering of streptomycetes for uncovering their hidden potential to produce novel compounds and for the improved production of secondary metabolites

Glutamate- and GABA-Modulated Connectivity in Auditory Hallucinations—A Combined Resting State fMRI and MR Spectroscopy Study

Background: Auditory verbal hallucinations (AVH) have been linked to aberrant interhemispheric connectivity between the left and the right superior temporal gyrus (STG), labeled the interhemispheric miscommunication theory. The present study investigated if interhemispheric miscommunication is modulated at the neurochemical level by glutamate (Glu) and gamma-aminobutyric acid (GABA) concentrations in temporal and prefrontal lobe areas, as proposed by the theory. Methods: We combined resting-state fMRI connectivity with MR spectroscopy (MRS) in a sample of 81 psychosis patients, comparing patients with high hallucination severity (high-AVH) and low hallucination severity (low-AVH) groups. Glu and GABA concentrations were acquired from the left STG and the anterior cingulate cortex (ACC), an area of cognitive control that has been proposed to modulate STG functioning in AVH. Results: Functional connectivity showed significant interaction effects between AVH Group and ACC-recorded Glu and GABA metabolites. Follow-up tests showed that there was a significant positive association for Glu concentration and interhemispheric STG connectivity in the high-AVH group, while there was a significant negative association for GABA concentration and interhemispheric STG connectivity in the low-AVH group. Conclusion: The results show neurochemical modulation of STG interhemispheric connectivity, as predicted by the interhemispheric miscommunication hypothesis. Furthermore, the findings are in line with an excitatory/inhibitory imbalance model for AVH. By combining different neuroimaging modalities, the current results provide a more comprehensive insight into the neural correlates of AVH.publishedVersio