7,609 research outputs found
The Australian Incident Monitoring Study in Intensive Care: AIMS-ICU. The development and evaluation of an incident reporting system in intensive care
Publisher's copy made available with the permission of the publisher © 1996 Australian Society of AnaesthetistsIntensive care units are complex, dynamic patient management environments. Incidents and accidents can be caused by human error, by problems inherent in complex systems, or by a combination of these. Study objectives were to develop and evaluate an incident reporting system. A report form was designed eliciting a description of the incident, contextual information and contributing factors. Staff group sessions using open-ended questions, observations in the workplace and a review of earlier narratives were used to develop the report form. Three intensive care units participated in a two-month evaluation study. Feedback questionnaires were used to assess staff attitudes and understanding, project design and organization. These demonstrated a positive attitude and good understanding by more than 90% participants. Errors in communication, technique, problem recognition and charting were the predisposing factors most commonly chosen in the 128 incidents reported. It was concluded that incident monitoring may be a suitable technique for improving patient safety in intensive care.U. Beckman, L.F. West, G.J. Groombridge, I. Baldwin, G.K. Hart, D.G. Clayton, R.K. Webb, W.B. Runcima
Bulk and shear relaxation in glasses and highly viscous liquids
The ratio between the couplings of a relaxational process to compression and
shear, respectively, is calculated in the Eshelby picture of structural
rearrangements within a surrounding elastic matrix, assuming a constant density
of stable structures in distortion space. The result is compared to
experimental data for the low-temperature tunneling states in glasses and to
Prigogine-Defay data at the glass transition from the literature.Comment: 6 pages, 2 figures, 53 references; version after understanding the
Prigogine-Defay ratio at the glass transition in the accompanying paper
arXiv:1203.3555 [cond-mat.dis-nn
Chapter 9: Aquatic Macroinvertebrates, Section A: Aquatic Macroinvertebrates (Exclusive of Mosquitoes)
Final Report. Excerpt (Chapter 9, Section A) from The Des Plaines River Wetlands
Demonstration Project, Volume II, Baseline Survey, edited by Donald L. Hey and Nancy S.
PhilippiReport issued on: October 1985INHS Technical Report prepared for Wetlands Research, Inc
The fluorine abundance in a Galactic Bulge AGB star measured from CRIRES spectra
We present measurements of the fluorine abundance in a Galactic Bulge
Asymptotic Giant Branch (AGB) star. The measurements were performed using high
resolution K-band spectra obtained with the CRIRES spectrograph, which has been
recently installed at ESO's VLT, together with state-of-the-art model
atmospheres and synthetic spectra. This represents the first fluorine abundance
measurement in a Galactic Bulge star, and one of few measurements of this kind
in a third dredge-up oxygen-rich AGB star. The F abundance is found to be close
to the solar value scaled down to the metallicity of the star, and in agreement
with Disk giants that are comparable to the Bulge giant studied here. The
measurement is of astrophysical interest also because the star's mass can be
estimated rather accurately (1.4 \lesssim M/\mathrm{M}_{\sun} \lesssim 2.0).
AGB nucleosynthesis models predict only a very mild enrichment of F in such low
mass AGB stars. Thus, we suggest that the fluorine abundance found in the
studied star is representative for the star's natal cloud, and that fluorine
must have been produced at a similar level in the Bulge and in the Disk.Comment: 11 pages, 1 figure, accepted for publication by Ap
Kinetic theory of age-structured stochastic birth-death processes
Classical age-structured mass-action models such as the McKendrick-von Foerster equation have been extensively studied but are unable to describe stochastic fluctuations or population-size-dependent birth and death rates. Stochastic theories that treat semi-Markov age-dependent processes using, e.g., the Bellman-Harris equation do not resolve a population's age structure and are unable to quantify population-size dependencies. Conversely, current theories that include size-dependent population dynamics (e.g., mathematical models that include carrying capacity such as the logistic equation) cannot be easily extended to take into account age-dependent birth and death rates. In this paper, we present a systematic derivation of a new, fully stochastic kinetic theory for interacting age-structured populations. By defining multiparticle probability density functions, we derive a hierarchy of kinetic equations for the stochastic evolution of an aging population undergoing birth and death. We show that the fully stochastic age-dependent birth-death process precludes factorization of the corresponding probability densities, which then must be solved by using a Bogoliubov-–Born–-Green–-Kirkwood-–Yvon-like hierarchy. Explicit solutions are derived in three limits: no birth, no death, and steady state. These are then compared with their corresponding mean-field results. Our results generalize both deterministic models and existing master equation approaches by providing an intuitive and efficient way to simultaneously model age- and population-dependent stochastic dynamics applicable to the study of demography, stem cell dynamics, and disease evolution
Quantum authentication with key recycling
We show that a family of quantum authentication protocols introduced in
[Barnum et al., FOCS 2002] can be used to construct a secure quantum channel
and additionally recycle all of the secret key if the message is successfully
authenticated, and recycle part of the key if tampering is detected. We give a
full security proof that constructs the secure channel given only insecure
noisy channels and a shared secret key. We also prove that the number of
recycled key bits is optimal for this family of protocols, i.e., there exists
an adversarial strategy to obtain all non-recycled bits. Previous works
recycled less key and only gave partial security proofs, since they did not
consider all possible distinguishers (environments) that may be used to
distinguish the real setting from the ideal secure quantum channel and secret
key resource.Comment: 38+17 pages, 13 figures. v2: constructed ideal secure channel and
secret key resource have been slightly redefined; also added a proof in the
appendix for quantum authentication without key recycling that has better
parameters and only requires weak purity testing code
Multidimensional cosmological models: cosmological and astrophysical implications and constraints
We investigate four-dimensional effective theories which are obtained by
dimensional reduction of multidimensional cosmological models with factorizable
geometry and consider the interaction between conformal excitations of the
internal space (geometrical moduli excitations) and Abelian gauge fields. It is
assumed that the internal space background can be stabilized by minima of an
effective potential. The conformal excitations over such a background have the
form of massive scalar fields (gravitational excitons) propagating in the
external spacetime. We discuss cosmological and astrophysical implications of
the interaction between gravexcitons and four-dimensional photons as well as
constraints arising on multidimensional models of the type considered in our
paper. In particular, we show that due to the experimental bounds on the
variation of the fine structure constant, gravexcitons should decay before
nucleosynthesis starts. For a successful nucleosynthesis the masses of the
decaying gravexcitons should be m>10^4 GeV. Furthermore, we discuss the
possible contribution of gravexcitons to UHECR. It is shown that, at energies
of about 10^{20}eV, the decay length of gravexcitons with masses m>10^4 GeV is
very small, but that for m <10^2 GeV it becomes much larger than the
Greisen-Zatsepin-Kuzmin cut-off distance. Finally, we investigate the
possibility for gravexciton-photon oscillations in strong magnetic fields of
astrophysical objects. The corresponding estimates indicate that even the high
magnetic field strengths of magnetars are not sufficient for an efficient and
copious production of gravexcitons.Comment: 16 pages, LaTeX2e, minor changes, improved references, to appear in
PR
Considerations for using potential surrogate endpoints in cancer screening trials.
The requirement of large-scale expensive cancer screening trials spanning decades creates considerable barriers to the development, commercialisation, and implementation of novel screening tests. One way to address these problems is to use surrogate endpoints for the ultimate endpoint of interest, cancer mortality, at an earlier timepoint. This Review aims to highlight the issues underlying the choice and use of surrogate endpoints for cancer screening trials, to propose criteria for when and how we might use such endpoints, and to suggest possible candidates. We present the current landscape and challenges, and discuss lessons and shortcomings from the therapeutic trial setting. It is hugely challenging to validate a surrogate endpoint, even with carefully designed clinical studies. Nevertheless, we consider whether there are candidates that might satisfy the requirements defined by research and regulatory bodies
Observable Effects of Scalar Fields and Varying Constants
We show by using the method of matched asymptotic expansions that a
sufficient condition can be derived which determines when a local experiment
will detect the cosmological variation of a scalar field which is driving the
spacetime variation of a supposed constant of Nature. We extend our earlier
analyses of this problem by including the possibility that the local region is
undergoing collapse inside a virialised structure, like a galaxy or galaxy
cluster. We show by direct calculation that the sufficient condition is met to
high precision in our own local region and we can therefore legitimately use
local observations to place constraints upon the variation of "constants" of
Nature on cosmological scales.Comment: Invited Festscrift Articl
'Just open your eyes a bit more': The methodological challenges of researching black and minority ethnic students' experiences of physical education teacher education
In this paper we discuss some of the challenges of centralising 'race' and ethnicity in Physical Education (PE) research, through reflecting on the design and implementation of a study exploring Black and minority ethnic students' experiences of their teacher education. Our aim in the paper is to contribute to ongoing theoretical and methodological debates about intersectionality, and specifically about difference and power in the research process. As McCorkel and Myers notes, the 'researchers' backstage'-the assumptions, motivations, narratives and relations-that underpin any research are not always made visible and yet are highly significant in judging the quality and substance of the resulting project. As feminists, we argue that the invisibility of 'race' and ethnicity within Physical Education Teacher Education (PETE), and PE research more widely, is untenable; however, we also show how centralising 'race' and ethnicity raised significant methodological and epistemological questions, particularly given our position as White researchers and lecturers. In this paper, we reflect on a number of aspects of our research 'journey': the theoretical and methodological challenges of operationalising concepts of 'race' and ethnicity, the practical issues and dilemmas involved in recruiting participants for the study, the difficulties of 'talking race' personally and professionally and challenges of representing the experiences of 'others'. © 2012 Copyright Taylor and Francis Group, LLC
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