2,899 research outputs found
Antimicrobial Activity of the Quinoline Derivative HT61 against Staphylococcus aureus Biofilms.
Staphylococcus aureus biofilms are a significant problem in health care settings, partly due to the presence of a nondividing, antibiotic-tolerant subpopulation. Here we evaluated treatment of S. aureus UAMS-1 biofilms with HT61, a quinoline derivative shown to be effective against nondividing Staphylococcus spp. HT61 was effective at reducing biofilm viability and was associated with increased expression of cell wall stress and division proteins, confirming its potential as a treatment for S. aureus biofilm infections
Slow life history leaves endangered snake vulnerable to illegal collecting.
Global wildlife trade is a multibillion-dollar industry and a significant driver of vertebrate extinction risk. Yet, few studies have quantified the impact of wild harvesting for the illicit pet trade on populations. Long-lived species, by virtue of their slow life history characteristics, may be unable to sustain even low levels of collecting. Here, we assessed the impact of illegal collecting on populations of endangered broad-headed snakes (Hoplocephalus bungaroides) at gated (protected) and ungated (unprotected) sites. Because broad-headed snakes are long-lived, grow slowly and reproduce infrequently, populations are likely vulnerable to increases in adult mortality. Long-term data revealed that annual survival rates of snakes were significantly lower in the ungated population than the gated population, consistent with the hypothesis of human removal of snakes for the pet trade. Population viability analysis showed that the ungated population has a strongly negative population growth rate and is only prevented from ultimate extinction by dispersal of small numbers of individuals from the gated population. Sensitivity analyses showed that the removal of a small number of adult females was sufficient to impose negative population growth and suggests that threatened species with slow life histories are likely to be especially vulnerable to illegal collecting
Solar and Heliospheric Observatory (SOHO) (1995)
SOHO is the most comprehensive space mission ever devoted to the study of the Sun and its nearby cosmic environment known as the heliosphere. It was launched in December 1995 and is currently funded at least through the end of 2016. SOHO's twelve instruments observe and measure structures and processes occurring inside as well as outside the Sun, and which reach well beyond Earth's orbit into the heliosphere. While designed to study the "quiet" Sun, the new capabilities and combination of several SOHO instruments have revolutionized space weather research. This article gives a brief mission overview, summarizes selected highlight results, and describes SOHO's contributions to space weather research. These include cotemporaneous EUV imaging of activity in the Sun's corona and white light imaging of coronal mass ejections in the extended corona, magnetometry in the Sun's atmosphere, imaging of far side activity, measurements to predict solar proton storms, and monitoring solar wind plasma at the L1 Lagrangian point, 1.5 million kilometers upstream of Earth
A High Deuterium Abundance at z=0.7
Of the light elements, the primordial abundance of deuterium, (D/H)_p,
provides the most sensitive diagnostic for the cosmological mass density
parameter Omega_B. Recent high redshift (D/H) measurements are highly
discrepant, although this may reflect observational uncertainties. The larger
(D/H) values, which imply a low Omega_B and require the Universe to be
dominated by non-baryonic matter (dynamical studies indicate a higher total
density parameter), cause problems for galactic chemical evolution models since
they have difficulty in reproducing the large decline down to the lower
present-day (D/H). Conversely, low (D/H) values imply an Omega_B greater than
derived from ^7Li and ^4He abundance measurements, and may require a deuterium
abundance evolution that is too low to easily explain. Here we report the first
measurement at intermediate redshift, where the observational difficulties are
smaller, of a gas cloud with ideal characteristics for this experiment. Our
analysis of the z = 0.7010 absorber toward 1718+4807 indicates (D/H) = 2.0 +/-
0.5 x 10^{-4} which is in the high range. This and other independent
observations suggests there may be a cosmological inhomogeneity in (D/H)_p of
at least a factor of ten.Comment: 6 pages, 1 figur
Using the theory of planned behaviour as a process evaluation tool in randomised trials of knowledge translation strategies : A case study from UK primary care
Peer reviewedPublisher PD
3D Visualisation of Additive Occlusion and Tunable Full-Spectrum Fluorescence in Calcite
From biomineralization to synthesis, organic additives provide an effective means of controlling crystallisation processes. There is growing evidence that these additives are often occluded within the crystal lattice, where this promises an elegant means of creating nanocomposites and tuning physical properties. Here, we use the incorporation of sulfonated fluorescent dyes to gain new understanding of additive occlusion in calcite (CaCO3), and to link morphological changes to occlusion mechanisms. We demonstrate that these additives are incorporated within specific zones, as defined by the growth conditions, and show how occlusion can govern changes in crystal shape. Fluorescence spectroscopy and lifetime imaging microscopy also show that the dyes experience unique local environments within different zones. Our strategy was then extended to simultaneously incorporate mixtures of dyes, whose fluorescence cascade creates calcite nanoparticles that fluoresce white. This offers a simple strategy for generating biocompatible and stable fluorescent nanoparticles whose output can be tuned as required
Health and well-being in work in Merthyr Tydfil: a biopsychosocial approach. Well-being in Work Stage 2: final report to the Wales Centre for Health and Welsh Assembly Government.
Health and well-being in work in Merthyr Tydfil: a biopsychosocial approach. Well-being in Work Stage 2: final report to the Wales Centre for Health and Welsh Assembly Government.
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