Mechanics of couple-stress fluid coatings

The formal development of a theory of viscoelastic surface fluids with bending resistance - their kinematics, dynamics, and rheology are discussed. It is relevant to the mechanics of fluid drops and jets coated by a thin layer of immiscible fluid with rather general rheology. This approach unifies the hydrodynamics of two-dimensional fluids with the mechanics of an elastic shell in the spirit of a Cosserat continuum. There are three distinct facets to the formulation of surface continuum mechanics. Outlined are the important ideas and results associated with each: the kinematics of evolving surface geometries, the conservation laws governing the mechanics of surface continua, and the rheological equations of state governing the surface stress and moment tensors

Women and Health Coverage: The Affordability Gap

Explores the unique barriers that women face in obtaining health insurance, paying premiums, and affording healthcare services, and maintains that future proposals for improving health policy must address these disparities

Efficiency of cosmic ray reflections from an ultrarelativistic shock wave

The process of cosmic ray acceleration up to energies in excess of $10^{20}$ eV at relativistic shock waves with large Lorentz factors, $\Gamma \gg 1$ requires $\sim \Gamma^2$ particle energy gains at single reflections from the shock (cf. Gallant & Achterberg 1999). In the present comment, applying numerical simulations we address an efficiency problem arising for such models. The actual efficiency of the acceleration process is expected to be substantially lower than the estimates of previous authors.Comment: 3 pages, 3 figures, accepted for publication in MNRAS (Letters

Angular size and emission time scales of relativistic fireballs

The detection of delayed X-ray, optical and radio emission, ``afterglow,'' associated with gamma-ray bursts (GRBs) is consistent with models, where the bursts are produced by relativistic expanding blast waves, driven by expanding fireballs at cosmological distances. In particular, the time scales over which radiation is observed at different wave bands agree with model predictions. It had recently been claimed that the commonly used relation between observation time t and blast wave radius r, t=r/2\gamma^{2}c where \gamma(r) is the fluid Lorentz factor, should be replaced with t=r/16\gamma^{2}c due to blast wave deceleration. Applying the suggested deceleration modification would make it difficult to reconcile observed time scales with model predictions. It would also imply an apparent source size which is too large to allow attributing observed radio variability to diffractive scintillation. We present a detailed analysis of the implications of the relativistic hydrodynamics of expanding blast waves to the observed afterglow. We find that modifications due to shock deceleration are small, therefore allowing for both the observed afterglow time scales and for diffractive scintillation. We show that at time t the fireball appears on the sky as a narrow ring of radius h=r/\gamma and width 0.1h, where r and t are related by t=r/2\gamma^{2}c.Comment: Submitted to ApJL (11 pages, LaTeX

Overexpression of an activated REL mutant enhances the transformed state of the human B-lymphoma BJAB cell line and alters its gene expression profile

The human REL proto-oncogene encodes a transcription factor in the nuclear factor (NF)-kappaB family. Overexpression of REL is acutely transforming in chicken lymphoid cells, but has not been shown to transform any mammalian lymphoid cell type. In this report, we show that overexpression of a highly transforming mutant of REL (RELDeltaTAD1) increases the oncogenic properties of the human B-cell lymphoma BJAB cell line, as shown by increased colony formation in soft agar, tumor formation in SCID (severe combined immunodeficient) mice, and adhesion. BJAB-RELDeltaTAD1 cells also show decreased activation of caspase in response to doxorubicin. BJAB-RELDeltaTAD1 cells have increased levels of active nuclear REL protein as determined by immunofluorescence, subcellular fractionation and electrophoretic mobility shift assay. Overexpression of RELDeltaTAD1 in BJAB cells has transformed the gene expression profile of BJAB cells from that of a germinal center B-cell subtype of diffuse large B-cell lymphoma (DLBCL) (GCB-DLBCL) to that of an activated B-cell subtype (ABC-DLBCL), as evidenced by increased expression of many ABC-defining mRNAs. Upregulated genes in BJAB-RELDeltaTAD1 cells include several NF-kappaB targets that encode proteins previously implicated in B-cell development or oncogenesis, including BCL2, IRF4, CD40 and VCAM1. The cell system we describe here may be valuable for further characterizing the molecular details of REL-induced lymphoma in humans.P42 ES007381 - NIEHS NIH HHS; R01 CA047763 - NCI NIH HHS; CA047763 - NCI NIH HHS; R01 CA047763-20 - NCI NIH HHS; P42 ES007381-140019 - NIEHS NIH HHS; 5 P42 ES07381 - NIEHS NIH HHS; P42 ES007381-150019 - NIEHS NIH HHS; R01 CA047763-19 - NCI NIH HH

Dust sublimation by GRBs and its implications

The prompt optical flash recently detected accompanying GRB990123 suggests that, for at least some GRBs, gamma-ray emission is accompanied by prompt optical-UV emission with luminosity L(1-7.5eV)=10^{49}(\Delta\Omega/4\pi)erg/s, where \Delta\Omega is the solid angle into which gamma-ray and optical-UV emission is beamed. Such an optical-UV flash can destroy dust in the beam by sublimation out to an appreciable distance, approximately 10 pc, and may clear the dust out of as much as 10^7(\Delta\Omega/4\pi)M_sun of molecular cloud material on an apparent time scale of 10 seconds. Detection of time dependent extinction on this time scale would therefore provide strong constraints on the GRB source environment. Dust destruction implies that existing, or future, observations of not-heavily-reddened fireballs are not inconsistent with GRBs being associated with star forming regions. In this case, however, if gamma-ray emission is highly beamed, the expanding fireball would become reddened on a 1 week time scale. If the optical depth due to dust beyond approximately 8 pc from the GRB is 0.2<\tau_V<2, most of the UV flash energy is converted to infra-red, \lambda \sim 1 micron, radiation with luminosity \sim 10^{41} erg/s extending over an apparent duration of \sim 20(1+z)(\Delta\Omega/0.01) day. Dust infra-red emission may already have been observed in GRB970228 and GRB980326, and may possibly explain their unusual late time behavior.Comment: 16 pages, including 1 figure, submitted to Ap

Stability of the Forward/Reverse Shock System Formed by the Impact of a Relativistic Fireball on an Ambient Medium

We analyze the stability of a relativistic double (forward/reverse) shock system which forms when the fireball of a Gamma-Ray Burst (GRB) impacts on the surrounding medium. We find this shock system to be stable to linear global perturbations for either a uniform or a wind (r^{-2}) density profile of the ambient medium. For the wind case, we calculate analytically the frequencies of the normal modes which could modulate the early short-term variability of GRB afterglows. We find that perturbations in the double shock system could induce oscillatory fluctuations in the observed flux on short (down to seconds) time scales during the early phase of an afterglow.Comment: ApJ, submitted, 26 pages, 5 figure

The energy production rate & the generation spectrum of UHECRs

We derive simple analytic expressions for the flux and spectrum of ultra-high energy cosmic-rays (UHECRs) predicted in models where the CRs are protons produced by extra-Galactic sources. For a power-law scaling of the CR production rate with redshift and energy, d\dot{n} /dE\propto E^-\alpha (1+z)^m, our results are accurate at high energy, E>10^18.7 eV, to better than 15%, providing a simple and straightforward method for inferring d\dot{n}/dE from the observed flux at E. We show that current measurements of the UHECR spectrum, including the latest Auger data, imply E^2d\dot{n}/dE(z=0)=(0.45\pm0.15)(\alpha-1) 10^44 erg Mpc^-3 yr^-1 at E<10^19.5 eV with \alpha roughly confined to 2\lesseq\alpha<2.7. The uncertainty is dominated by the systematic and statistic errors in the experimental determination of individual CR event energy, (\Delta E/E)_{sys} (\Delta E/E)_{stat} ~20%. At lower energy, d\dot{n}/dE is uncertain due to the unknown Galactic contribution. Simple models in which \alpha\simeq 2 and the transition from Galactic to extra-Galactic sources takes place at the "ankle", E ~10^19 eV, are consistent with the data. Models in which the transition occurs at lower energies require a high degree of fine tuning and a steep spectrum, \alpha\simeq 2.7, which is disfavored by the data. We point out that in the absence of accurate composition measurements, the (all particle) energy spectrum alone cannot be used to infer the detailed spectral shapes of the Galactic and extra-Galactic contributions.Comment: 9 pages, 11 figures, minor revision

TeV Neutrinos from Successful and Choked Gamma-Ray Bursts

Core collapse of massive stars resulting in a relativistic fireball jet which breaks through the stellar envelope is a widely discussed scenario for gamma-ray burst production. For very extended or slow rotating stars, the fireball may be unable to break through the envelope. Both penetrating and choked jets will produce, by photo-meson interactions of accelerated protons, a burst of neutrinos with energies in excess of 5 TeV while propagating in the envelope. The predicted flux, from both penetrating and chocked fireballs, should be easily detectable by planned cubic kilometer neutrino telescopes.Comment: Phys.Rev.Letters, in press, final version accepted 8/31/01 (orig. 3/17/01

Probable Performance of Steiner Tree Algorithms

In this paper we consider the probable performance of three polynomial time approximation algorithms for the Steiner tree problem with respect to a specific random graph model. The Steiner problem asks us to find a minimum cost spanning subgraph (tree) for a subset D of modes in a graph