Spatial clusters of gonorrhoea in England with particular reference to the outcome of partner notification: 2012 and 2013

Background: This study explored spatial-temporal variation in diagnoses of gonorrhoea to identify and quantify endemic areas and clusters in relation to patient characteristics and outcomes of partner notification (PN) across England, UK. Methods: Endemic areas and clusters were identified using a two-stage analysis with Kulldorff’s scan statistics (SaTScan). Results Of 2,571,838 tests, 53,547 diagnoses were gonorrhoea positive (positivity = 2.08%). The proportion of diagnoses in heterosexual males was 1.5 times that in heterosexual females. Among index cases, men who have sex with men (MSM) were 8 times more likely to be diagnosed with gonorrhoea than heterosexual males (p<0.0001). After controlling for age, gender, ethnicity and deprivation rank, 4 endemic areas were identified including 11,047 diagnoses, 86% of which occurred in London. 33 clusters included 17,629 diagnoses (34% of total diagnoses in 2012 and 2013) and spanned 21 locations, some of which were dominated by heterosexually acquired infection, whilst others were MSM focused. Of the 53,547 diagnoses, 14.5% (7,775) were the result of PN. The proportion of patients who attended services as a result of PN varied from 0% to 61% within different age, gender and sexual orientation cohorts. A third of tests resulting from PN were positive for gonorrhoea. 25% of Local Authorities (n = 81, 95% CI: 20.2, 29.5) had a higher than expected proportion for female PN diagnoses as compared to 16% for males (n = 52, 95% CI: 12.0, 19.9). Conclusions: The English gonorrhoea epidemic is characterised by spatial-temporal variation. PN success varied between endemic areas and clusters. Greater emphasis should be placed on the role of PN in the control of gonorrhoea to reduce the risk of onward transmission, re-infection, and complications of infection

Magnetar giant flare high-energy emission

High energy ($> 250$ keV) emission has been detected persisting for several tens of seconds after the initial spike of magnetar giant flares. It has been conjectured that this emission might arise via inverse Compton scattering in a highly extended corona generated by super-Eddington outflows high up in the magnetosphere. In this paper we undertake a detailed examination of this model. We investigate the properties of the required scatterers, and whether the mechanism is consistent with the degree of pulsed emission observed in the tail of the giant flare. We conclude that the mechanism is consistent with current data, although the origin of the scattering population remains an open question. We propose an alternative picture in which the emission is closer to that star and is dominated by synchrotron radiation. The $RHESSI$ observations of the December 2004 flare modestly favor this latter picture. We assess the prospects for the Fermi Gamma-Ray Space Telescope to detect and characterize a similar high energy component in a future giant flare. Such a detection should help to resolve some of the outstanding issues.Comment: 20 pages, 14 figure

Radiation exposure of LDEF: Initial results

Initial results from LDEF include radiation detector measurements from four experiments, P0006, P0004, M0004, and A0015. The detectors were located on both the leading and trailing edges of the orbiter and also on the Earthside end. This allowed the directional dependence of the incoming radiation to be measured. Total absorbed doses from thermoluminescent detectors (TLDs) verified the predicted spatial east-west dose ratio dependence of a factor approx. 2.5, due to trapped proton anisotropy in the South Atlantic Anomaly. On the trailing edge of the orbiter a range of doses from 6.64 to 2.91 Gy were measured under Al equivalent shielding of 0.42 to 1.11 g/sq cm. A second set of detectors near this location yielded doses of 6.48 to 2.66 Gy under Al equivalent shielding of 0.48 to 15.4 g/sq cm. On the leading edge, doses of 2.58 to 2.10 Gy were found under Al equivalent shielding of 1.37 to 2.90 g/sq cm. Initial charged particle LET (linear energy transfer) spectra, fluxes, doses and dose equivalents, for LET in H2O greater than or = 8 keV/micron, were measured with plastic nuclear track detectors (PNTDs) located in two experiments. Also preliminary data on low energy neutrons were obtained from detectors containing (6)LiF foils

Charged particle LET-spectra measurements aboard LDEF

The linear energy transfer (LET) spectra of charged particles was measured in the 5 to 250 keV/micron (water) interval with CR-39 and in the 500 to 1500 keV/micron (water) interval with polycarbonate plastic nuclear track detectors (PNTDs) under different shielding depths in the P0006 experiment. The optimal processing conditions were determined for both PNTDs in relation to the relatively high track densities due to the long term exposure in space. The total track density was measured over the selected samples, and tracks in coincidence on the facing surfaces of two detector sheets were selected for measuring at the same position on each sheet. The short range (SR) and Galactic Cosmic Ray (GCR) components were measured separately with CR-39 PNTDs and the integral dose and dose rate spectra of charged particles were also determined. The high LET portion of the LET spectra was measured with polycarbonate PNTDs with high statistical accuracy. This is a unique result of this exposure due to the low flux of these types of particles for typical spaceflight durations. The directional dependence of the charged particles at the position of the P0006 experiment was also studied by four small side stacks which surrounded the main stack and by analyzing the dip angle and polar angle distributions of the measured SR and GCR particle tracks in the main stack

Temporal Correlations of Local Network Losses

We introduce a continuum model describing data losses in a single node of a packet-switched network (like the Internet) which preserves the discrete nature of the data loss process. {\em By construction}, the model has critical behavior with a sharp transition from exponentially small to finite losses with increasing data arrival rate. We show that such a model exhibits strong fluctuations in the loss rate at the critical point and non-Markovian power-law correlations in time, in spite of the Markovian character of the data arrival process. The continuum model allows for rather general incoming data packet distributions and can be naturally generalized to consider the buffer server idleness statistics

Three-dimensional shielding effects on charged particle fluences measured in the P0006 experiment of LDEF

Three-dimensional shielding effects on cosmic ray charged particle fluences were measured with plastic nuclear track detectors in the P0006 experiment on Long Duration Exposure Facility (LDEF). The azimuthal and polar angle distributions of the galactic cosmic ray particles (mostly relativistic iron) were measured in the main stack and in four side stacks of the P0006 experiment, located on the west end of the LDEF satellite. A shadowing effect of the shielding of the LDEF satellite is found. Total fluence of stopping protons was measured as a function of the position in the main and side stacks of the P0006 experiment. Location dependence of total track density is explained by the three-dimensional shielding model of the P0006 stack. These results can be used to validate 3D mass model and transport code calculations and also for predictions of the outer radiation environment for the Space Station Freedom

Online prostate cancer screening decision aid for at-risk men: A randomized trial

Objective: This study examines the efficacy of an online decision aid (DA) for men with a family history of prostate cancer. Methods: Unaffected Australian men (40 - 79 years) with at least one affected relative completed the first online questionnaire, were randomized to read either the tailored DA (intervention) or nontailored information about prostate cancer screening (control), then completed a questionnaire postreading and 12 months later. The primary outcome was decisional conflict regarding prostate specific antigen (PSA) testing. The impact of the DA on longitudinal outcomes was analyzed by using random intercept mixed effects models. Logistic and linear regressions were used to analyze the impact of the DA on screening behavior and decision regret. Stage of decision-making was tested as a moderator for decisional conflict and decision regret. The frequency of online material access was recorded. Results: the DA had no effect on decisional conflict, knowledge, inclination toward PSA testing, accuracy of perceived risk, or screening behavior. However, among men considering PSA testing, those who read the DA had lower decision regret compared with men who read the control materials, β=.34 , p \u3c.001, 95% confidence interval (CI) = [.22, .53]. Conclusions: This is the first study to our knowledge to evaluate the uptake and efficacy of an online screening DA among men with a family history of prostate cancer. Men who were undecided about screening at baseline benefitted from the DA, experiencing less regret 12 months later. In relation to decisional conflict, the control materials may have operated as a less complex and equally informative DA

Sandpiles on multiplex networks

We introduce the sandpile model on multiplex networks with more than one type of edge and investigate its scaling and dynamical behaviors. We find that the introduction of multiplexity does not alter the scaling behavior of avalanche dynamics; the system is critical with an asymptotic power-law avalanche size distribution with an exponent $\tau = 3/2$ on duplex random networks. The detailed cascade dynamics, however, is affected by the multiplex coupling. For example, higher-degree nodes such as hubs in scale-free networks fail more often in the multiplex dynamics than in the simplex network counterpart in which different types of edges are simply aggregated. Our results suggest that multiplex modeling would be necessary in order to gain a better understanding of cascading failure phenomena of real-world multiplex complex systems, such as the global economic crisis.Comment: 7 pages, 7 figure

Cooperation and Contagion in Web-Based, Networked Public Goods Experiments

A longstanding idea in the literature on human cooperation is that cooperation should be reinforced when conditional cooperators are more likely to interact. In the context of social networks, this idea implies that cooperation should fare better in highly clustered networks such as cliques than in networks with low clustering such as random networks. To test this hypothesis, we conducted a series of web-based experiments, in which 24 individuals played a local public goods game arranged on one of five network topologies that varied between disconnected cliques and a random regular graph. In contrast with previous theoretical work, we found that network topology had no significant effect on average contributions. This result implies either that individuals are not conditional cooperators, or else that cooperation does not benefit from positive reinforcement between connected neighbors. We then tested both of these possibilities in two subsequent series of experiments in which artificial seed players were introduced, making either full or zero contributions. First, we found that although players did generally behave like conditional cooperators, they were as likely to decrease their contributions in response to low contributing neighbors as they were to increase their contributions in response to high contributing neighbors. Second, we found that positive effects of cooperation were contagious only to direct neighbors in the network. In total we report on 113 human subjects experiments, highlighting the speed, flexibility, and cost-effectiveness of web-based experiments over those conducted in physical labs