Careers 2020: options for future careers work in English schools.

Careers work in English schools has endured much turbulence recently. The government has now established a statutory duty on schools to secure provision, placing commissioning of careers advice and guidance in the hands of schools rather than local authorities or central government. But the duty is framed very loosely, comes with no funding and offers no clear model of provision. The previous funding for face-to-face guidance from qualified careers advisers has been removed, as has the duty for schools to provide careers education. So what should schools’ careers offers look like in future? How can schools ensure the quality of the career development support that is so vital for young people, and particularly so for those who cannot rely on their existing networks for advice and opportunities?Pearson Think Tan

Defining next-generation additive manufacturing applications for the Ministry of Defence (MoD)

“Additive Manufacturing” (AM) is an emerging, highly promising and disruptive technology which is catching the attention of the Defence sector due to the versatility it is offering. Through the combination of design freedom, technology compactness and high deposition rates, technology stakeholders can potentially exploit rapid, delocalized and flexible production. Having the capability to produce highly tailored, fully dense, potentially optimized products, on demand and next to the point of use makes this emerging and immature technology a game changer in the “Defence Support Service” (DS2) sector. Furthermore, if the technology is exploited for the Royal Navy, featured with extended and disrupted supply chains, the benefits are very promising. While most of the AM research and efforts are focusing on the manufacturing/process and design opportunities/topology optimization, this paper aims to provide a creative but educated and validated forecast on what AM can do for the Royal Navy in the future. This paper aims to define the most promising next generation Additive Manufacturing applications for the Royal Navy in the 2025 – 2035 decade. A multidisciplinary methodology has been developed to structure this exploratory applied research study. Moreover, different experts of the UK Defence Value Chain have been involved for primary research and for verification/validation purposes. While major concerns have been raised on process/product qualification and current AM capabilities, the results show that there is a strong confidence on the disruptive potential of AM to be applied in front-end of DS2 systems to support “Complex Engineering Systems” in the future. While this paper provides only next-generation AM applications for RN, substantial conceptual development work has to be carried out to define an AM based system which is able to, firstly satisfy the “spares demands” of a platform and secondly is able to perform in critical environments such as at sea

Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage

The Schizosaccharomyces pombe SMC proteins Rad18 (Smc6) and Spr18 (Smc5) exist in a high-M(r) complex which also contains the non-SMC proteins Nse1, Nse2, Nse3, and Rad62. The Smc5-6 complex, which is essential for viability, is required for several aspects of DNA metabolism, including recombinational repair and maintenance of the DNA damage checkpoint. We have characterized Nse2 and show here that it is a SUMO ligase. Smc6 (Rad18) and Nse3, but not Smc5 (Spr18) or Nse1, are sumoylated in vitro in an Nse2-dependent manner, and Nse2 is itself autosumoylated, predominantly on the C-terminal part of the protein. Mutations of C195 and H197 in the Nse2 RING-finger-like motif abolish Nse2-dependent sumoylation. nse2.SA mutant cells, in which nse2.C195S-H197A is integrated as the sole copy of nse2, are viable, whereas the deletion of nse2 is lethal. Smc6 (Rad18) is sumoylated in vivo: the sumoylation level is increased upon exposure to DNA damage and is drastically reduced in the nse2.SA strain. Since nse2.SA cells are sensitive to DNA-damaging agents and to exposure to hydroxyurea, this implicates the Nse2-dependent sumoylation activity in DNA damage responses but not in the essential function of the Smc5-6 complex

The Fourth North American Echinoderm Conference, 22-26 August 2001

Friends of Echinoderms Share Their Research and Renew Their Enthusiasm John H. Dearborn NAEC History and Commentary John M. Lawrence Papers on Sea Urchin Fisheries and Aquaculture at the NAEC 2001: A PerspectiveJohn M. Lawrence and Stephen A. Watts Plenary Abstract

Characterization of 40-Gbit/s pulses generated using a lithium niobate modulator at 1550 nm using frequency resolved optical gating

The characteristics of 40-Gbit/s pulses generated by exploiting the nonlinear characteristics of a Mach-Zender Lithium Niobate modulator are presented. A high spectral resolution frequency resolved optical gating apparatus has been developed to allow for the complete characterization of the intensity and phase of these pulses. The use of these measurements to simplify the design and optimization of an 80-Gbit/s pulse source, based on this 40-Gbit/s source followed by a nonlinear fiber compressor and multiplexer, is also demonstrated

Tackling unemployment, supporting business and developing careers

The issue of unemployment remains high on the political agenda. However, there is evidence that employers can be wary of employing people who are out of work. Employer practice is key, both in terms of providing employment opportunities to job seekers, and in providing space for low-skilled people to develop their skills and cement their attachment to the labour market. This report discusses the role of career guidance in mediating between job seekers and employers to allow both to achieve their objectives.The issue of unemployment remains high on the political agenda. However, there is evidence that employers can be wary of employing people who are out of work. Employer practice is key, both in terms of providing employment opportunities to job seekers, and in providing space for low-skilled people to develop their skills and cement their attachment to the labour market. This report discusses the role of career guidance in mediating between job seekers and employers to allow both to achieve their objectives

Prediction of LDEF ionizing radiation environment

The Long Duration Exposure Facility (LDEF) spacecraft flew in a 28.5 deg inclination circular orbit with an altitude in the range from 172 to 258.5 nautical miles. For this orbital altitude and inclination two components contribute most of the penetrating charge particle radiation encountered - the galactic cosmic rays and the geomagnetically trapped Van Allen protons. Where shielding is less than 1.0 g/sq cm geomagnetically trapped electrons make a significant contribution. The 'Vette' models together with the associated magnetic filed models were used to obtain the trapped electron and proton fluences. The mission proton doses were obtained from the fluence using the Burrell proton dose program. For the electron and bremsstrahlung dose we used the Marshall Space Flight Center (MSFC) electron dose program. The predicted doses were in general agreement with those measured with on-board thermoluminescent detector (TLD) dosimeters. The NRL package of programs, Cosmic Ray Effects on MicroElectronics (CREME), was used to calculate the linear energy transfer (LET) spectrum due to galactic cosmic rays (GCR) and trapped protons for comparison with LDEF measurements

TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent

Toll-like receptor (TLR) signaling induces a rapid reorganization of the actin cytoskeleton in cultured mouse dendritic cells (DC), leading to enhanced antigen endocytosis and a concomitant loss of filamentous actin–rich podosomes. We show that as podosomes are lost, TLR signaling induces prominent focal contacts and a transient reduction in DC migratory capacity in vitro. We further show that podosomes in mouse DC are foci of pronounced gelatinase activity, dependent on the enzyme membrane type I matrix metalloprotease (MT1-MMP), and that DC transiently lose the ability to degrade the extracellular matrix after TLR signaling. Surprisingly, MMP inhibitors block TLR signaling–induced podosome disassembly, although stimulated endocytosis is unaffected, which demonstrates that the two phenomena are not obligatorily coupled. Podosome disassembly caused by TLR signaling occurs normally in DC lacking MT1-MMP, and instead requires the tumor necrosis factor α–converting enzyme ADAM17 (a disintegrin and metalloprotease 17), which demonstrates a novel role for this “sheddase” in regulating an actin-based structure

Optimization of optical data transmitters for 40-Gb/s lightwave systems using frequency resolved optical gating

The measurement technique of frequency resolved optical gating has been used to optimize the phase of a 40-GHz train of optical pulses generated using a continuous-wave laser gated with an external modulator. This technique will be vital for optimization of optical transmitters to be used in systems operating at 40 Gb/s and beyond, as standard measurement techniques will not suffice to optimize such high-speed systems

Utilizing Lipopolysaccharide in Exhaled Breath Condensate to Diagnose Gram Negative Pneumonia

A device for collecting exhaled breath condensate from a subject. The device comprises a plunger assembly and a stopper. The stopper is connected to the plunger disk of the plunger assembly by a plurality of support pins and is configured for sealing engagement. The device is utilized to collect exhaled breath condensate from both spontaneously breathing and mechanically ventilated subjects and the devices utilized to determine whether lipopolysaccharide is present in the collected exhaled breath condensate