Whole-brain patterns of 1H-magnetic resonance spectroscopy imaging in Alzheimer's disease and dementia with Lewy bodies

Acknowledgements We thank Craig Lambert for his help in processing the MRS data. The study was funded by the Sir Jules Thorn Charitable Trust (grant ref: 05/JTA) and was supported by the National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre and the Biomedical Research Unit in Lewy Body Dementia based at Newcastle upon Tyne Hospitals National Health Service (NHS) Foundation Trust and Newcastle University and the NIHR Biomedical Research Centre and Biomedical Research Unit in Dementia based at Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge.Peer reviewedPublisher PD

Defining the gap between research and practice in public relations programme evaluation - towards a new research agenda

The current situation in public relations programme evaluation is neatly summarized by McCoy who commented that 'probably the most common buzzwords in public relations in the last ten years have been evaluation and accountability' (McCoy 2005, 3). This paper examines the academic and practitioner-based literature and research on programme evaluation and it detects different priorities and approaches that may partly explain why the debate on acceptable and agreed evaluation methods continues. It analyses those differences and proposes a research agenda to bridge the gap and move the debate forward

Effect of contrast on the perception of direction of a moving pattern

A series of experiments examining the effect of contrast on the perception of moving plaids was performed to test the hypothesis that the human visual system determines the direction of a moving plaid in a two-staged process: decomposition into component motion followed by application of the intersection-of-contraints rule. Although there is recent evidence that the first tenet of the hypothesis is correct, i.e., that plaid motion is initially decomposed into the motion of the individual grating components, the nature of the second-stage combination rule has not yet been established. It was found that when the gratings within the plaid are of different contrast the preceived direction is not predicted by the intersection-of-constraints rule. There is a strong (up to 20 deg) bias in the direction of the higher-constrast grating. A revised model, which incorporates a contrast-dependent weighting of perceived grating speed as observed for one-dimensional patterns, can quantitatively predict most of the results. The results are then discussed in the context of various models of human visual motion processing and of physiological responses of neurons in the primate visual system

Economic evaluation of the treatment of grade II haemorrhoids : a comparison of stapled haemorrhoidopexy and rubber band ligation.

The definitive version is available at www3.interscience.wiley.comPeer reviewedPostprin

On locations and properties of the multicritical point of Gaussian and +/-J Ising spin glasses

We use transfer-matrix and finite-size scaling methods to investigate the location and properties of the multicritical point of two-dimensional Ising spin glasses on square, triangular and honeycomb lattices, with both binary and Gaussian disorder distributions. For square and triangular lattices with binary disorder, the estimated position of the multicritical point is in numerical agreement with recent conjectures regarding its exact location. For the remaining four cases, our results indicate disagreement with the respective versions of the conjecture, though by very small amounts, never exceeding 0.2%. Our results for: (i) the correlation-length exponent $\nu$ governing the ferro-paramagnetic transition; (ii) the critical domain-wall energy amplitude $\eta$; (iii) the conformal anomaly $c$; (iv) the finite-size susceptibility exponent $\gamma/\nu$; and (v) the set of multifractal exponents $\{\eta_k \}$ associated to the moments of the probability distribution of spin-spin correlation functions at the multicritical point, are consistent with universality as regards lattice structure and disorder distribution, and in good agreement with existing estimates.Comment: RevTeX 4, 9 pages, 2 .eps figure

Regulation of blastocyst formation.

Preimplantation or pre-attachment development encompasses the free -living period of mammalian embryogenesis, which directs development of the zygote through to the blastocyst stage. Blastocyst formation is essential for implantation, establishment of pregnancy and is a principal determinant of embryo quality prior to embryo transfer. Cavitation (blastocyst formation) is driven by the expression of specific sets of gene products that direct the acquisition of cell polarity within the trophectoderm, which is both the first epithelium of development and the outer cell layer encircling the inner cell mass of the blastocyst. Critical gene families controlling these events include: the E-cadherin-catenin cell adhesion family, the tight junction gene family, the Na/K-ATPase gene family and perhaps the aquaporin gene family. This review will update the roles of each of these gene families in trophectoderm differentiation and blastocyst formation. The current principal hypothesis under investigation is that blastocyst formation is mediated by a trans-trophectoderm ion gradient(s) established, in part, by Na/K-ATPase, which drives the movement of water through aquaporins (AQPs) across the epithelium into the extracellular space of the blastocyst to form the fluid-filled blastocoel. The trophectoderm tight junctional permeability seal regulates the leakage of blastocoel fluid, and also assists in the maintenance of a polarized Na/K-ATPase distribution to the basolateral plasma membrane domain of the mural trophectoderm. The cell-to-cell adhesion provided by the E-cadherin-catenin gene families is required for the establishment of the tight junction seal and the maintenance of the polarized Na/K-ATPase distribution. Blastocyst formation is therefore directly linked with trophectoderm cell differentiation, which arises through fundamental cell biological processes that are associated with the establishment of cell polarity

String windings in the early universe

We study string dynamics in the early universe. Our motivation is the proposal of Brandenberger and Vafa, that string winding modes may play a key role in decompactifying three spatial dimensions. We model the universe as a homogeneous but anisotropic 9-torus filled with a gas of excited strings. We adopt initial conditions which fix the dilaton and the volume of the torus, but otherwise assume all states are equally likely. We study the evolution of the system both analytically and numerically to determine the late-time behavior. We find that, although dynamical evolution can indeed lead to three large spatial dimensions, such an outcome is not statistically favored.Comment: 26 pages, LaTeX, 4 eps figure

Effective Field Theory Approach to String Gas Cosmology

We derive the 4D low energy effective field theory for a closed string gas on a time dependent FRW background. We examine the solutions and find that although the Brandenberger-Vafa mechanism at late times no longer leads to radion stabilization, the radion rolls slowly enough that the scenario is still of interest. In particular, we find a simple example of the string inspired dark matter recently proposed by Gubser and Peebles.Comment: 19 pages, 2 figures, comments adde