Pseudo-nonstationarity in the scaling exponents of finite-interval time series

The accurate estimation of scaling exponents is central in the observational study of scale-invariant phenomena. Natural systems unavoidably provide observations over restricted intervals; consequently, a stationary stochastic process (time series) can yield anomalous time variation in the scaling exponents, suggestive of nonstationarity. The variance in the estimates of scaling exponents computed from an interval of N observations is known for finite variance processes to vary as ~1/N as N for certain statistical estimators; however, the convergence to this behavior will depend on the details of the process, and may be slow. We study the variation in the scaling of second-order moments of the time-series increments with N for a variety of synthetic and “real world” time series, and we find that in particular for heavy tailed processes, for realizable N, one is far from this ~1/N limiting behavior. We propose a semiempirical estimate for the minimum N needed to make a meaningful estimate of the scaling exponents for model stochastic processes and compare these with some “real world” time series

Pre- and post-processing for Cosmic/NASTRAN on personal computers and mainframes

An interface between Cosmic/NASTRAN and GIFTS has recently been released, combining the powerful pre- and post-processing capabilities of GIFTS with Cosmic/NASTRAN's analysis capabilities. The interface operates on a wide range of computers, even linking Cosmic/NASTRAN and GIFTS when the two are on different computers. GIFTS offers a wide range of elements for use in model construction, each translated by the interface into the nearest Cosmic/NASTRAN equivalent; and the options of automatic or interactive modelling and loading in GIFTS make pre-processing easy and effective. The interface itself includes the programs GFTCOS, which creates the Cosmic/NASTRAN input deck (and, if desired, control deck) from the GIFTS Unified Data Base, COSGFT, which translates the displacements from the Cosmic/NASTRAN analysis back into GIFTS; and HOSTR, which handles stress computations for a few higher-order elements available in the interface, but not supported by the GIFTS processor STRESS. Finally, the versatile display options in GIFTS post-processing allow the user to examine the analysis results through an especially wide range of capabilities, including such possibilities as creating composite loading cases, plotting in color and animating the analysis

Flows on scales of 150 Mpc?

We investigate the reality of large-scale streaming on scales of up to 150 Mpc using the peculiar motions of galaxies in three directions. New R-band CCD photometry and spectroscopy for elliptical galaxies is used. The Fundamental Plane distance indicator is calibrated using the Coma cluster and an inhomogeneous Malmquist bias correction is applied. A linear bulk-flow model is fitted to the peculiar velocities in the sample regions and the results do not reflect the bulk flow observed by Lauer and Postman (LP). Accounting for the difference in geometry between the galaxy distribution in the three regions and the LP clustersconfirms the disagreement; assuming a low-density CDM power spectrum, we find that the observed bulk flow of the galaxies in our sample excludes the LP bulk flow at the 99.8% confidence level.Comment: 16 pages, 1 figur

Mechanisms Regulating the Association of Protein Phosphatase 1 with Spinophilin and Neurabin

Protein phosphorylation is a key mediator of signal transduction, allowing for dynamic regulation of substrate activity. Whereas protein kinases obtain substrate specificity by targeting specific amino acid sequences, serine/threonine phosphatase catalytic subunits are much more promiscuous in their ability to dephosphorylate substrates. To obtain substrate specificity, serine/threonine phosphatases utilize targeting proteins to regulate phosphatase subcellular localization and catalytic activity. Spinophilin and its homologue neurabin are two of the most abundant dendritic spine-localized protein phosphatase 1 (PP1) targeting proteins. The association between spinophilin and PP1 is increased in the striatum of animal models of Parkinson's disease (PD). However, mechanisms that regulate the association of spinophilin and neurabin with PP1 are unclear. Here, we report that the association between spinophilin and PP1α or PP1γ1 was increased by CDK5 expression and activation in a heterologous cell system. This increased association is at least partially due to phosphorylation of PP1. Conversely, CDK5 expression and activation decreased the association of PP1 with neurabin. As with dopamine depletion, methamphetamine (METH) abuse causes persistent alterations in dopamine signaling which influence striatal medium spiny neuron function and biochemistry. Moreover, both METH toxicity and dopamine depletion are associated with deficits in motor control and motor learning. Pathologically, we observed a decreased association of spinophilin with PP1 in rat striatum evaluated one month following a binge METH paradigm. Behaviorally, we found that loss of spinophilin recapitulates rotarod pathology previously observed in dopamine-depleted and METH-treated animals. Together, these data have implications in multiple disease states associated with altered dopamine signaling such as PD and psychostimulant drug abuse and delineate a novel mechanism by which PP1 interactions with spinophilin and neurabin may be differentially regulated

Dosimetric comparison study between intensity modulated radiation therapy and three-dimensional conformal proton therapy for pelvic bone marrow sparing in the treatment of cervical cancer.

The objective was to compare intensity-modulated radiation therapy (IMRT) with 3D conformal proton therapy (3DCPT) in the treatment of cervical cancer. In particular, each technique's ability to spare pelvic bone marrow (PBM) was of primary interest in this study. A total of six cervical cancer patients (3 postoperative and 3 intact) were planned and analyzed. All plans had uniform 1.0 cm CTV-PTV margin and satisfied the 95% PTV with 100% isodose (prescription dose = 45 Gy) coverage. Dose-volume histograms (DVH) were analyzed for comparison. The overall PTV and PBM volumes were 1035.9 ± 192.2 cc and 1151.4 ± 198.3 cc, respectively. In terms of PTV dose conformity index (DCI) and dose homogeneity index (DHI), 3DCPT was slightly superior to IMRT with 1.00 ± 0.001, 1.01 ± 0.02, and 1.10 ± 0.02, 1.13 ± 0.01, respectively. In addition, 3DCPT demonstrated superiority in reducing lower doses (i.e., V30 or less) to PBM, small bowel and bladder. Particularly in PBM, average V10 and V20 reductions of 10.8% and 7.4% (p = 0.001 and 0.04), respectively, were observed. However, in the higher dose range, IMRT provided better sparing (> V30). For example, in small bowel and PBM, average reductions in V45 of 4.9% and 10.0% (p = 0.048 and 0.008), respectively, were observed. Due to its physical characteristics such as low entrance dose, spread-out Bragg peak and finite particle range of protons, 3DCPT illustrated superior target coverage uniformity and sparing of the lower doses in PBM and other organs. Further studies are, however, needed to fully exploit the benefits of protons for general use in cervical cancer

National Register of Historic Places Eligibility Testing of Site 41SM385 Within TxDOT\u27s Tyler District, Smith County, Texas

PBS&J, an Atkins company, was contracted by the North East Texas Regional Mobility Authority to conduct National Register of Historic Places eligibility testing of site 41SM385, a prehistoric campsite on a small rise above the floodplain of Indian Creek in western Smith County, Texas. Testing investigations were conducted during March and September 2009. The site was subjected to a systematic program of shovel testing, mechanical trenching, and hand excavation in an effort to identify cultural features or living surfaces and optimize recovery of diagnostic faunal, floral, and artifactual remains. The recovered cultural artifacts indicate that site 41SM385 represents a probable Woodland and Caddo‐aged occupation on a small rise on the creek floodplain. The Woodland component is based on recovered small Gary and Kent projectile points characteristic of Woodland culture of the region. The Caddo component is based on ceramic sherds of probable Early or Middle Caddo origin identified at the site. Radiocarbon dating of four ceramic sherds supports these assessments with three sherds dating to the Early to Middle Caddo periods and one sherd dating to the Woodland period. The lack of identified cultural features suggests that the Woodland component probably represents a series of ephemeral usages of the location, probably as short‐term campsites. The Caddo‐aged artifacts at the site probably represent a series of ephemeral usage of the location, either as a resource procurement locus ancillary to nearby site 41SM404 or as a short‐term campsite. The testing program failed to locate living surfaces or cultural features containing in situ artifactual or organic remains preserved on the site. The absence of cultural features and the paucity of lithic tools or ceramic remains make more‐meaningful functional interpretation infeasible. For this reason, the site lacks the data resources that would warrant National Register of Historic Places isting or designation as a State Archeological Landmark. No further work is recommended

Stellar Encounters with Massive Star-Disk Systems

The dense, clustered environment in which massive stars form can lead to interactions with neighboring stars. It has been hypothesized that collisions and mergers may contribute to the growth of the most massive stars. In this paper we extend the study of star-disk interactions to explore encounters between a massive protostar and a less massive cluster sibling using the publicly available SPH code GADGET-2. Collisions do not occur in the parameter space studied, but the end state of many encounters is an eccentric binary with a semi-major axis ~ 100 AU. Disk material is sometimes captured by the impactor. Most encounters result in disruption and destruction of the initial disk, and periodic torquing of the remnant disk. We consider the effect of the changing orientation of the disk on an accretion driven jet, and the evolution of the systems in the presence of on-going accretion from the parent core.Comment: 11 pages, 10 figures, accepted to Ap

Detecting gravitational waves from test-mass bodies orbiting a Kerr black hole with P-approximant templates

In this study we apply post-Newtonian (T-approximants) and resummed post-Newtonian (P-approximants) to the case of a test-particle in equatorial orbit around a Kerr black hole. We compare the two approximants by measuring their effectualness (i.e. larger overlaps with the exact signal), and faithfulness (i.e. smaller biases while measuring the parameters of the signal) with the exact (numerical) waveforms. We find that in the case of prograde orbits, T-approximant templates obtain an effectualness of ~0.99 for spins q < 0.75. For 0.75 < q < 0.95, the effectualness drops to about 0.82. The P-approximants achieve effectualness of > 0.99 for all spins up to q = 0.95. The bias in the estimation of parameters is much lower in the case of P-approximants than T-approximants. We find that P-approximants are both effectual and faithful and should be more effective than T-approximants as a detection template family when q > 0. For q < 0 both T- and P-approximants perform equally well so that either of them could be used as a detection template family. However, for parameter estimation, the P-approximant templates still outperforms the T-approximants.Comment: 11 Pages - 9 figures. Accepted for publication. Proceedings of GWDAW 9. Special edition of Classical and Quantum Gravit

Nonthermal Supermassive Dark Matter

We discuss several cosmological production mechanisms for nonthermal supermassive dark matter and argue that dark matter may be elementary particles of mass much greater than the weak scale. Searches for dark matter should not be limited to weakly interacting particles with mass of the order of the weak scale, but should extend into the supermassive range as well.Comment: 11 page LaTeX file. No major changes. Version accepted by PR