The construction of a bedrock geology model for the UK: UK3D_v2015

This report is available for download on the BGS UK3D web page to allow the reader to better understand the context and development of UK3D, a national network, or ‘fence diagram model’, of bedrock geology cross-sections. It also explains the development of the metadata underpinning the model and therefore supports use and understanding of UK3D. The pre-existing BGS GB3D model provided the only nationally consistent representation of the bedrock geology of Great Britain to depths of at least 1 km. The latest version of this model was released in 2014 as the GB3D_v2014 and accompanying report (Mathers et al. 2014b). However, the existing GB3D_v2014 model lacked equivalent scale presentation of a fence diagram model for Northern Ireland. It was recognised that in order to provide comparable geological information across the United Kingdom it was necessary to upgrade the model to a UK3D fence diagram model incorporating Northern Ireland, with rigorous peer review performed to enable an enhanced dataset. The objective of this study was therefore to further develop the GB3D model, outlined by Mathers et al. (2014a and b), into a UK3D model by the incorporation of 36 deep boreholes and a framework of 15 cross-sections for Northern Ireland. The appropriate applications for the revised model are for geoscience communication and education to illustrate the national and regional bedrock geology of the United Kingdom to a depth of at least 1 km with an intended resolution of use in the 1:250 000 to 1:1 million scale range. Limitations inherent in the model preclude such applications as detailed geological assessments, resource-reserve estimation and exploration, and any representation or use outside the intended resolution range. The new model produced by this study UK3D_v2015 supersedes the earlier 2014 version for England and Wales, for which areas of the fence diagrams remain the same. The Scottish portion of the model remains unchanged from the earlier 2012 version. The new dataset is a wholly owned BGS product and as with its forerunners it is freely available from the BGS website http://bgs.ac.uk as downloads in a variety of formats

Translation and validation of the Brazilian version of the Cerebral Palsy Quality of Life Questionnaire for Children – child report

AbstractObjectiveTo verify the psychometric properties of the Cerebral Palsy: Quality of Life Questionnaire Children – child report (CPQol-Child) questionnaire, after it was translated and culturally adapted into Brazilian Portuguese.MethodsAfter the translation and cultural adaptation of the tool into Brazilian Portuguese, the questionnaire was answered by 65 children with cerebral palsy, aged 9–12 years. The intraclass correlation coefficient and Cronbach's alpha were used to assess the reliability and internal consistency of the tool and its validity was analyzed through the association between CPQol-Child: self-report tool and Kidscreen-10 using Pearson's correlation coefficient.ResultsInternal consistency ranged from 0.6579 to 0.8861, the intraobserver reliability from 0.405 to 0.894, and the interobserver from 0.537 to 0.937. There was a weak correlation between the participation domain and physical health of CPQol-Child: self-report tool and Kidscreen-10.ConclusionThe analysis suggests that the tool has psychometric acceptability for the Brazilian population

Update on biomarkers in neuromyelitis optica

Neuromyelitis optica (NMO) (and NMO spectrum disorder) is an autoimmune inflammatory disease of the CNS primarily affecting spinal cord and optic nerves. Reliable and sensitive biomarkers for onset, relapse, and progression in NMO are urgently needed because of the heterogeneous clinical presentation, severity of neurologic disability following relapses, and variability of therapeutic response. Detecting aquaporin-4 (AQP4) antibodies (AQP4-IgG or NMO-IgG) in serum supports the diagnosis of seropositive NMO. However, whether AQP4-IgG levels correlate with disease activity, severity, response to therapy, or long-term outcomes is unclear. Moreover, biomarkers for patients with seronegative NMO have yet to be defined and validated. Collaborative international studies hold great promise for establishing and validating biomarkers that are useful in therapeutic trials and clinical management. In this review, we discuss known and potential biomarkers for NMO

A Mathematical Model of Liver Cell Aggregation In Vitro

The behavior of mammalian cells within three-dimensional structures is an area of intense biological research and underpins the efforts of tissue engineers to regenerate human tissues for clinical applications. In the particular case of hepatocytes (liver cells), the formation of spheroidal multicellular aggregates has been shown to improve cell viability and functionality compared to traditional monolayer culture techniques. We propose a simple mathematical model for the early stages of this aggregation process, when cell clusters form on the surface of the extracellular matrix (ECM) layer on which they are seeded. We focus on interactions between the cells and the viscoelastic ECM substrate. Governing equations for the cells, culture medium, and ECM are derived using the principles of mass and momentum balance. The model is then reduced to a system of four partial differential equations, which are investigated analytically and numerically. The model predicts that provided cells are seeded at a suitable density, aggregates with clearly defined boundaries and a spatially uniform cell density on the interior will form. While the mechanical properties of the ECM do not appear to have a significant effect, strong cell-ECM interactions can inhibit, or possibly prevent, the formation of aggregates. The paper concludes with a discussion of our key findings and suggestions for future work

Spatially resolving polycyclic aromatic hydrocarbons in Herbig Ae disks with VISIR-NEAR at the VLT

Context. The emission from polycyclic aromatic hydrocarbons (PAHs) arises from the uppermost layers of protoplanetary disks, higher than the optical/near-infrared scattered light and similar to the emission from the highly thick 12CO millimeter lines. The PAH intensity profiles trace the gas distribution and can constrain the penetration depth of UV radiation. Aims. We aim to constrain the spatial intensity profiles of the four strongest PAH emission features in the telluric N-band spectral region. Thereby, we seek to constrain the dependence of PAH properties on the (radial) location in the disk, such as charge state, the interrelation with the presence and dynamics of small silicate grains, and the correlation of PAH emission with gas or dust. Methods. We used the long-slit spectroscopy mode of the VISIR-NEAR experiment to perform diffraction-limited observations of eight nearby Herbig Ae protoplanetary disks. We extracted spectra for various locations along the slit with a spectral resolution of R ≈ 300 and performed a compositional fit at each spatial location using spectral templates of silicates and the four PAH bands. This yields the intensity versus location profiles of each species. Results. We obtained spatially resolved intensity profiles of the PAH emission features in the N band for five objects (AB Aurigae, HD 97048, HD 100546, HD 163296, and HD 169142). We observe two kinds of PAH emission geometry in our sample: centrally peaked (HD 97048) and ring-like (AB Aurigae, HD 100546, HD 163296, and potentially HD 169142). Comparing the spatial PAH emission profiles with near-infrared scattered light images, we find a strong correlation in the disk substructure but a difference in radial intensity decay rate. The PAH emission shows a less steep decline with distance from the star. Finally, we find a correlation between the presence of (sub)micron-sized silicate grains and the depletion of PAH emission within the inner regions of the disks. Conclusions. In this work we find the following: (1) PAH emission traces the extent of Herbig Ae disks to a considerable radial distance. (2) The correlation between the presence of silicate emission within the inner regions of disks and the depletion of PAH emission can result from dust-mixing and PAH coagulation mechanisms and competition over UV photons. (3) For all objects in our sample, PAHs undergo stochastic heating across the entire spatial extent of the disk and are not saturated. (4) The difference in radial intensity decay rates between the PAHs and scattered-light profiles may be attributed to shadowing and dust-settling effects, which impact the scattering grains more so than the PAHs

Role of adenylate cyclase 9 in the pharmacogenomic response to dalcetrapib clinical paradigm and molecular mechanisms in precision cardiovascular medicine

Following the neutral results of the dal-OUTCOMES trial, a genome-wide study identified the rs1967309 variant in the adenylate cyclase type 9 (ADCY9) gene on chromosome 16 as being associated with the risk of future cardiovascular events only in subjects taking dalcetrapib, a CETP (cholesterol ester transfer protein) modulator. Homozygotes for the minor A allele (AA) were protected from recurrent cardiovascular events when treated with dalcetrapib, while homozygotes for the major G allele (GG) had increased risk. Here, we present the current state of knowledge regarding the impact of rs1967309 in ADCY9 on clinical observations and biomarkers in dalcetrapib trials and the effects of mouse ADCY9 gene inactivation on cardiovascular physiology. Finally, we present our current model of the interaction between dalcetrapib and ADCY9 gene variants in the arterial wall macrophage, based on the intracellular role of CETP in the transfer of complex lipids from endoplasmic reticulum membranes to lipid droplets. Briefly, the concept is that dalcetrapib would inhibit CETP-mediated transfer of cholesteryl esters, resulting in a progressive inhibition of cholesteryl ester synthesis and free cholesterol accumulation in the endoplasmic reticulum. Reduced ADCY9 activity, by paradoxically leading to higher cyclic AMP levels and in turn increased cellular cholesterol efflux, could impart cardiovascular protection in rs1967309 AA patients. The ongoing dal-GenE trial recruited 6145 patients with the protective AA genotype and will provide a definitive answer to whether dalcetrapib will be protective in this population.Cardiolog

Low-mass pre--main-sequence stars in the Magellanic Clouds

[Abridged] The stellar Initial Mass Function (IMF) suggests that sub-solar stars form in very large numbers. Most attractive places for catching low-mass star formation in the act are young stellar clusters and associations, still (half-)embedded in star-forming regions. The low-mass stars in such regions are still in their pre--main-sequence (PMS) evolutionary phase. The peculiar nature of these objects and the contamination of their samples by the evolved populations of the Galactic disk impose demanding observational techniques for the detection of complete numbers of PMS stars in the Milky Way. The Magellanic Clouds, the companion galaxies to our own, demonstrate an exceptional star formation activity. The low extinction and stellar field contamination in star-forming regions of these galaxies imply a more efficient detection of low-mass PMS stars than in the Milky Way, but their distance from us make the application of special detection techniques unfeasible. Nonetheless, imaging with the Hubble Space Telescope yield the discovery of solar and sub-solar PMS stars in the Magellanic Clouds from photometry alone. Unprecedented numbers of such objects are identified as the low-mass stellar content of their star-forming regions, changing completely our picture of young stellar systems outside the Milky Way, and extending the extragalactic stellar IMF below the persisting threshold of a few solar masses. This review presents the recent developments in the investigation of PMS stars in the Magellanic Clouds, with special focus on the limitations by single-epoch photometry that can only be circumvented by the detailed study of the observable behavior of these stars in the color-magnitude diagram. The achieved characterization of the low-mass PMS stars in the Magellanic Clouds allowed thus a more comprehensive understanding of the star formation process in our neighboring galaxies.Comment: Review paper, 26 pages (in LaTeX style for Springer journals), 4 figures. Accepted for publication in Space Science Review