Letter from Anna Reid Waterman to Emma and Dan[iel Muir], 1889 Jul 21.

Crete, Neb.July 21, 1889.Dear Aunt Emma & Uncle Dave,Mother told me of the little stranger that has [illegible] come into your house. Accept congratulations if it is not too late. Kiss the little fellow for me and tell him we would like to see him in Crete with his mother before so very long, and his father too if business is not too pressing. How delighted we would be to have you all make me a visit in my own new home. We have been married almost ten weeks. How the time does fly & can hardly realize that it has been so long. I have a very happy home. All come and see me. I want to thank you heartily for the nice sugar spoon you sent me. I hardly know what you can thing of me for being so long in acknowledging it, but that is just one of my many faults to put off letter writing. I have written just two letters since I have been married and one of those was to my father. Forgive my negligence and accept many thanks. Our trip east was enjoyed thoroughly. We were away two weeks taking in Omaha, Plattsmouth and Chicago. We were pleased to get home and settled after so much sightseeing. With lots of love to all I will close.Lovingly yours - Anna Reid Waterma

Does frenotomy help infants with tongue-tie overcome breastfeeding difficulties?

Q: Does frenotomy help infants with tongue-tie overcome breastfeeding difficulties? Evidence-based answer: Probably not. No evidence exists for improved latching after frenotomy, and evidence concerning improvements in maternal comfort is conflicting. At best, frenotomy improves maternal nipple pain by 10% and maternal subjective sense of improvement over the short term (0 to 2 weeks) (strength of recommendation [SOR]: B, randomized controlled trials [RCTs] with conflicting results for maternal nipple pain and overall feeding). No studies have evaluated outcomes such as infant weight gain following frenotomy. Experts don't recommend frenotomy unless a clear association exists between ankyloglossia (tongue-tie) and breastfeeding problems. Frenotomy should be performed with anesthesia by an experienced clinician to minimize the risk of complications (SOR: C, a practice guideline.

La tumba hipogea de Bolores (Torres Vedras): una aproximación interdisciplinar a la comprensión del paisaje social del Neolítico Final/Edad del Cobre de la Península Ibérica

To better understand the sociopolitical landscape of the Portuguese Estremadura during the Late Neolithic/Copper Age, interdisciplinary excavations were conducted at Bolores (Torres Vedras), in the Sizandro River Valley. Following a test season in 1986, a University of Iowa team conducted four campaigns between 2007 and 2012. Bolores is a rock-cut tomb used primarily between 2800-2600 cal BC for the burial of adults, adolescents, and children (MNI=36). The architectural, material cultural, and bioarchaeological evidence suggests that Bolores housed the remains of a distinctive group of local individuals who marked their difference from other burial populations in the Sizandro and Estremadura through material culture and tomb architecture. Social differences were denoted spatially and through offerings of material goods. No social stratification is evident, however, that would suggest a state-level society: there are no wealthy child burials and no significant health or dietary disparities within this population or between it and others in the region.Para comprender mejor el paisaje sociopolítico de la Extremadura portuguesa durante el Neolítico Final/Edad del Cobre se han llevado a cabo excavaciones interdisciplinares en Bolores (Torres Vedras), en el valle del río Sizandro. Tras una campaña de prueba en 1986, un equipo de la Universidad de Iowa realizó cuatro campañas entre 2007 y 2012. Bolores es una tumba hipogea que fue utilizada principalmente entre 2800 y 2600 cal BCE como enterramiento colectivo para adultos, adolescentes y niños (NMI=36). Los datos arquitectónicos, bioarqueológicos y de cultura material analizados hasta la fecha sugieren que Bolores albergó los restos de un grupo social distintivo compuesto de individuos locales que marcaban sus diferencias con otras poblaciones funerarias del Sizandro y Extremadura portuguesa mediante la cultura material y la arquitectura funeraria. Las diferencias sociales en la población de Bolores fueron señaladas espacialmente y marcadas mediante las ofrendas de bienes materiales. Sin embargo, no se aprecia una estratificación social significativa que sugiera una sociedad de nivel estatal: no hay enterramientos infantiles ricos, ni disparidades en la salud o dieta de esta población funeraria o entre esta población y otras en la región de Torres Vedras

Explore Transplant at Home: A randomized control trial of an educational intervention to increase transplant knowledge for Black and White socioeconomically disadvantaged dialysis patients

BackgroundCompared to others, dialysis patients who are socioeconomically disadvantaged or Black are less likely to receive education about deceased donor kidney transplant (DDKT) and living donor kidney transplant (LDKT) before they reach transplant centers, often due to limited availability of transplant education within dialysis centers. Since these patients are often less knowledgeable or ready to pursue transplant, educational content must be simplified, made culturally sensitive, and presented gradually across multiple sessions to increase learning and honor where they are in their decision-making about transplant. The Explore Transplant at Home (ETH) program was developed to help patients learn more about DDKT and LDKT at home, with and without telephone conversations with an educator.Methods and study designIn this randomized controlled trial (RCT), 540 low-income Black and White dialysis patients with household incomes at or below 250 % of the federal poverty line, some of whom receive financial assistance from the Missouri Kidney Program, will be randomly assigned to one of three education conditions: (1) standard-of-care transplant education provided by the dialysis center, (2) patient-guided ETH (ETH-PG), and (3) health educator-guided ETH (ETH-EG). Patients in the standard-of-care condition will only receive education provided in their dialysis centers. Those in the two ETH conditions will receive four video and print modules delivered over an 8 month period by mail, with the option of receiving supplementary text messages weekly. In addition, patients in the ETH-EG condition will participate in multiple telephonic educational sessions with a health educator. Changes in transplant knowledge, decisional balance, self-efficacy, and informed decision making will be captured with surveys administered before and after the ETH education.DiscussionAt the conclusion of this RCT, we will have determined whether an education program administered to socioeconomically disadvantaged dialysis patients, over several months directly in their homes, can help more individuals learn about the options of DDKT and LDKT. We also will be able to examine the efficacy of different educational delivery approaches to further understand whether the addition of a telephone educator is necessary for increasing transplant knowledge.Trial registrationClinicalTrials.gov, NCT02268682

Zirconium-catalyzed alkene hydrophosphination and dehydrocoupling with an air-stable, fluorescent primary phosphine

Zirconium-catalyzed alkene hydrophosphination and dehydrocoupling with an air-stable, fluorescent primary phosphine 8-[(4-phosphino)phenyl]-4,4-dimethyl-1,3,5,7-tetramethyl-2,6-diethyl- 4-bora-3a,4a-diaza-s-indacene furnishes fluorescent phosphine products. Hydrophosphination of the fluorescent phosphine produces products with a complete selectivity for the secondary product. A key intermediate in catalysis, a zirconium phosphido compound, was isolated

A mid-third millennium BC collective burial cave in central Iberia: El Rebollosillo (Torrelaguna, Madrid)

El Rebollosillo es una pequeña cueva kárstica situada en el centro de la Península Ibérica utilizada para la disposición de enterramientos secundarios en la mitad del III milenio AC. Presentamos resultados bioantropológicos, isotópicos (87Sr/86Sr, δ13C y δ18O) y 16 dataciones radiocarbónicas de los restos humanos, una descripción cuantificada de los 43 fragmentos cerámicos y de caracterización mineralógica de 6 cuentas recuperadas durante la excavación de 1989, cuatro de las cuales probablemente proceden de Palazuelo de las Cuevas (Zamora). El análisis bioantropológico indica un mínimo de 21 individuos con todos los rangos de edad y sexo. Se han detectado bajos porcentajes de patologías, mayoritariamente cálculo dental y caries, con casos puntuales de cribra orbitalia, periostosis y artrosis. La disposición de los restos sugiere que sólo los adultos recibieron un tratamiento claramente individualizado, quizás acorde con un estatus adquirido con la edad. Proponemos que el registro representa la última fase de un programa mortuorio cuyas etapas previas debieron desarrollarse en otros lugares y valoramos estos resultados en el contexto del registro funerario regional.El Rebollosillo is a small karstic cave located in the center of Iberia used for the disposition of secondary burials during the mid third millennium BC. We present bioanthropological, isotopic (87Sr/86Sr, δ 13C y δ 18O) analyses and 16 radiocarbon dates on human remains, as well as mineralogical characterization of 6 beads (4 of them variscite from Palazuelo de las Cuevas, Zamora), and a quantitative analysis of 43 pottery fragments recovered during the 1989 excavations. A minimum of 21 individu-als have been identified, covering all age ranges and sex. Low percentages of pathologies have been detected, mainly dental calculus and caries, with specific cases of cribra orbitalia, periostosis and arthritis. Only adults received a clearly individualized treatment, suggestive of achieved status. We interpret the evidence as a multi-staged mortuary program, the last phase of which is documented at the site, with previous stages perhaps carried out elsewhere, and we evaluate these results in the context of the regional funerary record

Isotopic evidence for mobility in the Copper and Bronze Age Cemetery of Humanejos (Parla, Madrid): a diachronic approach using biological and archaeological variables

Over the last several decades, the application of aDNA and strontium isotope analyses on archaeologically recovered human remains has provided new avenues for the investigation of mobility in past societies. Data on human mobility can be valuable in the reconstruction of prehistoric residential patterns and kinship systems, which are at the center of human social organization and vary across time and space. In this paper, we aim to contribute to our understanding of mobility, residence, and kinship patterns in late Prehistoric Iberia (c. 3300–1400BC) by providing new strontium data on 44 individuals from the site of Humanejos (Parla, Madrid). The study presented here is multi-proxy and looks at these new data by interweaving biological, chronological, and archaeological information. This analysis found that 7/44 individuals buried at Humanejos could be identified as non-local to the necropolis. Although more men (n = 5) than women (n = 2) were found in the non-local category, and more non-local individuals were identified in the pre-Bell Beaker (n = 5) than in Bell Beaker (n = 1) or Bronze Age (n = 1), we find no statistically significant differences concerning sex or time period. This contrasts with other archaeological datasets for late prehistoric Europe which suggest higher female mobility, female exogamy, and male-centered residential patterns were common. At Humanejos, we have also identified one non-local female whose exceptional Beaker grave goods suggest she was an individual of special status, leading to additional questions about the relationships between gender, mobility, and social position in this region and time periodThe project leading to this publication has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie Grant Agreement No 891776, project “WOMAM. Women, Men and Mobility: Understanding Gender Inequality in Prehistory.” This article was also supported by the Spanish Ministerio de Ciencia e Innovación Grants No. PID2019-105690 GB-I00 and HAR2013- 47776-R, the Dirección General de Patrimonio Cultural (Comunidad de Madrid) and the SFB 1070 “Ressourcenkulturen” (DFG

Un enterramiento colectivo en cueva del III milenio AC en el centro de la Península Ibérica: el Rebollosillo (Torrelaguna, Madrid)

El Rebollosillo is a small karstic cave located in the center of Iberia used for the disposition of secondary burials during the mid third millennium BC. We present bioanthropological, isotopic ( 87 Sr/ 86 Sr, δ 13 C y δ 18 O) analyses and 16 radiocarbon dates on human remains, as well as mineralogical characterization of 6 beads (4 of them variscite from Palazuelo de las Cuevas, Zamora), and a quantitative analysis of 43 pottery fragments recovered during the 1989 excavations. A minimum of 21 individu-als have been identified, covering all age ranges and sex. Low percentages of pathologies have been detected, mainly dental calculus and caries, with specific cases of cribra orbitalia, periostosis and arthritis. Only adults received a clearly individualized treatment, suggestive of achieved status. We interpret the evidence as a multi-staged mortuary program, the last phase of which is documented at the site, with previous stages perhaps carried out elsewhere, and we evaluate these results in the context of the regional funerary record.El Rebollosillo es una pequeña cueva kárstica situada en el centro de la Península Ibérica utilizada para la disposición de enterramientos secundarios en la mitad del III milenio AC. Presentamos resultados bioantropológicos, isotópicos (87Sr/86Sr, δ13C y δ18O) y 16 dataciones radiocarbónicas de los restos humanos, una descripción cuantificada de los 43 fragmentos cerámicos y de caracterización mineralógica de 6 cuentas recuperadas durante la excavación de 1989, cuatro de las cuales probablemente proceden de Palazuelo de las Cuevas (Zamora). El análisis bioantropológico indica un mínimo de 21 individuos con todos los rangos de edad y sexo. Se han detectado bajos porcentajes de patologías, mayoritariamente cálculo dental y caries, con casos puntuales de cribra orbitalia, periostosis y artrosis. La disposición de los restos sugiere que sólo los adultos recibieron un tratamiento claramente individualizado, quizás acorde con un estatus adquirido con la edad. Proponemos que el registro representa la última fase de un programa mortuorio cuyas etapas previas debieron desarrollarse en otros lugares y valoramos estos resultados en el contexto del registro funerario regionalInvestigación desarrollada en el contexto de los proyectos HAR2013-47776-R y CGL2012-35199 del Ministerio de Ciencia y Competitividad y el proyecto Cód. 099100 de la FUA

Exposing Racial Discrimination: Implicit & Explicit Measures–The My Body, My Story Study of 1005 US-Born Black & White Community Health Center Members

Background To date, research on racial discrimination and health typically has employed explicit self-report measures, despite their potentially being affected by what people are able and willing to say. We accordingly employed an Implicit Association Test (IAT) for racial discrimination, first developed and used in two recent published studies, and measured associations of the explicit and implicit discrimination measures with each other, socioeconomic and psychosocial variables, and smoking. Methodology/Principal Findings Among the 504 black and 501 white US-born participants, age 35–64, randomly recruited in 2008–2010 from 4 community health centers in Boston, MA, black participants were over 1.5 times more likely (p<0.05) to be worse off economically (e.g., for poverty and low education) and have higher social desirability scores (43.8 vs. 28.2); their explicit discrimination exposure was also 2.5 to 3.7 times higher (p<0.05) depending on the measure used, with over 60% reporting exposure in 3 or more domains and within the last year. Higher IAT scores for target vs. perpetrator of discrimination occurred for the black versus white participants: for “black person vs. white person”: 0.26 vs. 0.13; and for “me vs. them”: 0.24 vs. 0.19. In both groups, only low non-significant correlations existed between the implicit and explicit discrimination measures; social desirability was significantly associated with the explicit but not implicit measures. Although neither the explicit nor implicit discrimination measures were associated with odds of being a current smoker, the excess risk for black participants (controlling for age and gender) rose in models that also controlled for the racial discrimination and psychosocial variables; additional control for socioeconomic position sharply reduced and rendered the association null. Conclusions Implicit and explicit measures of racial discrimination are not equivalent and both warrant use in research on racial discrimination and health, along with data on socioeconomic position and social desirability

Aeromonas spp.-mediated cell-contact cytotoxicity is associated with the presence of type III secretion system

In the study we examined the production of cytotonic and cytotoxic toxins and the presence of a type III secretion system (TTSS) in 64 Aeromonas spp. strains isolated from fecal specimens of patients with gastroenteritis. We observed that contact of the bacteria with host epithelial cells is a prerequisite for their cytotoxicity at 3 h incubation. Cell-contact cytotoxic activity of the strains was strongly associated with the presence of the TTSS. Culture supernatants of the strains induced low cytotoxicity effects at the same time of incubation. Cell-free supernatants of 61 (95%) isolates expressed cytotoxic activity which caused the destruction of HEp-2 cells at 24 h. Moreover, 44% strains were cytotonic towards CHO cells and 46% of strains invaded epithelial cells