IT SECTOR DEVELOPMENT IN CLUJ-NAPOCA. THE CASE OF SMEs

The purpose of this paper is to to explore the evolution of SMEs from Cluj-Napoca in the IT sector by looking into the following problems: the relationship between number of employees, type of ownership and type of activity, as well as relationship between profit, liabilities, turnover, type of ownership and type of activity. The results indicate that the sector is attractive for the investors no matter what type of activity they want to develop (production or outsourcing). The main reason that makes them invest is the well prepared and relatively low cost workforce. Moreover, under favorable conditions (increase in turnover, decrease in liabilities or liabilities/capital ratio), the trend of the profit is ascending, making from this sector an interesting one for the investors (Romanian or international). Thus, our models show that this possible increase of the profit is a moderate one. Further investigations show that the development of the sector is rather a moderate one not a “booming” one. The results are normal if we take into consideration the fact that the process of developing Cluj-Napoca as an IT pole is at the beginning

Acute disseminated encephalomyelitis: a call to the clinicians for keeping this rare condition on clinical radar

Acute disseminated encephalomyelitis is a rare disease of central nervous system, which can present with a variety of clinical manifestations. That is why first attack of ADEM, in particular remains a diagnostic puzzle. Early anticipation and diagnosis is important for better outcomes. We present a case of acute disseminated encephalomyelitis which initially had atypical clinical features with cough, expectoration, fever and later manifested strange neurological features, diagnosed to be a case of acute disseminated encephalomyelitis based on radio-imaging

Developmental Lead Exposure and Lifespan Alterations in Epigenetic Regulators and their Correspondence to Biomarkers of Alzheimer\u27s Disease

Introduction: Early life lead (Pb) exposure results in a latent increase in Alzheimer’s disease (AD)–related proteins, and cognitive deficits late in life in both rodents and primates. This study was con- ducted to investigate if these late life changes were accompanied by epigenetic alterations. Methods: Western blot analysis and RT-PCR were used to measure Deoxyribonucleic acid methyl- ation regulators (DNMT1, DNMT3a, MeCP2, MAT2A) and histone proteins (H3K9Ac, H3K4me2, H3K27me3). Results: Cerebral levels of DNMT1 and MeCP2 were significantly reduced in mice exposed to Pb early in life, whereas the expression of DNMT3a was not altered. Levels of MAT2a were increased in the Pb-exposed mice across the lifespan. H3K9Ac and H3K4me2, involved in gene activation, were decreased, whereas the repressive mark H3K27me3 was elevated. Discussion: Epigenetic modifiers are affected by the developmental exposure to Pb and may play a role in mediating the latent increases in AD-related proteins in the brain

Histone acetylation maps in aged mice developmentally exposed to lead: Epigenetic drift and Alzheimer-related genes

Aim: Early life exposure to lead (Pb) has been shown to increase late life biomarkers involved in Alzheimer\u27s disease (AD) pathology. Here, we tested the hypothesis that latent over expression of AD-related genes may be regulated through histone activation pathways. Methods: Chromatin immunoprecipitation sequencing was used to map the histone activation mark (H3K9Ac) to the mouse genome in developmentally Pb exposed mice on postnatal days 20, 270 and 700. Results: Exposure to Pb resulted in a global downregulation of H3K9Ac across the lifespan; except in genes associated with the Alzheimer pathway. Discussion: Early life exposure to Pb results in an epigenetic drift in H3K9Ac consistent with latent global gene repression. Alzheimer-related genes do not follow this trend