Long-Baseline Interferometric Multiplicity Survey of the Sco-Cen OB Association

We present the first multiplicity-dedicated long baseline optical interferometric survey of the Scorpius-Centaurus-Lupus-Crux association. We used the Sydney University Stellar Interferometer to undertake a survey for new companions to 58 Sco-Cen B- type stars and have detected 24 companions at separations ranging from 7-130mas, 14 of which are new detections. Furthermore, we use a Bayesian analysis and all available information in the literature to determine the multiplicity distribution of the 58 stars in our sample, showing that the companion frequency is F = 1.35 and the mass ratio distribution is best described as a power law with exponent equal to -0.46, agreeing with previous Sco-Cen high mass work and differing significantly from lower-mass stars in Tau-Aur. Based on our analysis, we estimate that among young B-type stars in moving groups, up to 23% are apparently single stars. This has strong implications for the understanding of high-mass star formation, which requires angular momentum dispersal through some mechanism such as formation of multiple systems.Comment: 7 figures, 5 tables, accepted for publication in MNRA

Online tool for monitoring adverse events in patients with cancer during treatment (eRAPID): field testing in a clinical setting

Objectives: Electronic patient self-Reporting of Adverse-events: Patient Information and aDvice (eRAPID) is an online system developed to support patient care during cancer treatment by improving the detection and management of treatment-related symptoms. Patients can complete symptom reports from home and receive severity-based self-management advice, including notifications to contact the hospital for severe symptoms. Patient data are available in electronic records for staff to review. Prior to the commencement of a randomised controlled trial (RCT), field testing of the intervention was undertaken to troubleshoot practical issues with intervention integration in clinical practice. Design: Observational clinical field testing. Setting: Medical oncology breast service in a UK cancer centre. Participants: 12 patients receiving chemotherapy for early breast cancer and 10 health professionals (oncologists and specialist nurses). Intervention: Patients were asked to use the eRAPID intervention and complete weekly online symptom reports during four cycles of chemotherapy. Clinical staff were invited to access and use patient data in clinical assessments. Analysis: Descriptive data on the frequency of online symptom report completion and severe symptom notifications were collated. Verbal and written feedback was collected from patients and staff and semistructured interviews were conducted to explore patient experiences. Interviews were transcribed and analysed thematically. Results: The testing ran from January 2014 to March 2014. Feedback from patients and staff was largely positive. Patients described eRAPID as ‘reassuring’ and ‘comforting’ and valued the tailored management advice. Several changes were made to refine eRAPID. In particular, improvement of the clinical notification, patient reminder systems and changes to patient and staff training. Conclusions: The field testing generated valuable results used to guide refinement of eRAPID prior to formal intervention evaluation. Feedback indicated that eRAPID has the potential to improve patients’ self-efficacy, knowledge and confidence with managing symptoms during treatment. A large-scale RCT is underway with data collection due to finish in October 2018

Effects of word predictability on eye movements during Arabic reading

Contextual predictability influences both the probability and duration of eye fixations on words when reading Latinate alphabetic scripts like English and German. However, it is unknown whether word predictability influences eye movements in reading similarly for Semitic languages like Arabic, which are alphabetic languages with very different visual and linguistic characteristics. Such knowledge is nevertheless important for establishing the generality of mechanisms of eye-movement control across different alphabetic writing systems. Accordingly, we investigated word predictability effects in Arabic in two eye-movement experiments. Both produced shorter fixation times for words with high compared to low predictability, consistent with previous findings. Predictability did not influence skipping probabilities for (four- to eight-letter) words of varying length and morphological complexity (Experiment 1). However, it did for short (three- to four-letter) words with simpler structures (Experiment 2). We suggest that word-skipping is reduced, and affected less by contextual predictability, in Arabic compared to Latinate alphabetic reading, because of specific orthographic and morphological characteristics of the Arabic script

Effect of Previous Stocking Rate of Rye-Ryegrass Pasture and Four Breed Types of Calves on Feedlot Performance

Last updated: 6/12/200

Previous Stocking Rate on Winter Pasture, Four Breed Types, and Feedlot Performance on Carcass Traits

Last updated: 6/12/200

Comparison of assessments of fitness to drive for people with dementia

Cognitive tests are used to inform recommendations about the fitness to drive of people with dementia. The Rookwood Driving Battery (RDB) and Dementia Drivers' Screening Assessment (DDSA) are neuropsychological batteries designed to assist in this process. The aim was to assess the concordance between the classifications (pass/fail) of the RDB and DDSA in individuals with dementia, and to compare any discordant classifications against on-road driving ability. Participants were identified by community mental health teams and psychiatrists. Twenty four participants were recruited. The mean age was 74.1 (SD 8.9) years and 18 (75%) were men. Each participant was assessed on the RDB and DDSA in an order determined by random allocation. Those with discrepant results also had an on-road assessment. The agreement between the tests was 54% using a cut-off of > 6 on the RDB, and 75% using the cut-off to > 10 on the RDB. Three participants with discrepant results agreed to be assessed on the road and all were found to be safe to drive. The findings suggested that there was poor concurrent validity between the RDB and DDSA. This raises questions about the choice of assessments in making clinical recommendations about fitness to drive in people with dementia

Optical cavity enhanced real-time absorption spectroscopy of CO₂ using laser amplitude modulation

We present a spectrometer based on the cavity enhanced amplitude modulated laser absorption spectroscopy (CEAMLAS) technique for measuring molecular gas absorption. This CEAMLAS spectrometer accurately measured a CO₂ absorption line at 1572.992 nm with effectively 100% measurement duty cycle. It achieved an absorption sensitivity of 5.2 × 10⁻⁹ Hz⁻¹∕² using a linear Fabry-Perot cavity with a modest finesse of ≈1000. We also used the spectrometer to perform preliminary measurements of the ¹³C/¹²C isotopic ratio in CO₂, yielding an isotopic signature δ ¹³C of −83±9‰ for our CO₂ sample.This research was funded by the Australian Research Council under the Project ID: LP100200604 and DE130101361

Asking the right questions to get the right answers: Using cognitive interviews to review the acceptability, comprehension and clinical meaningfulness of patient self-report adverse event items in oncology patients

Background: Standardized reporting of treatment-related adverse events (AE) is essential in clinical trials, usually achieved by using the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) reported by clinicians. Patient-reported adverse events (PRAE) may add value to clinician assessments, providing patient perspective on subjective toxicity. We developed an online patient symptom report and self-management system for real-time reporting and managing AE during cancer treatment integrated with electronic patient records (eRAPID). As part of this program we developed a patient version of the CTCAE (version 4.0), rephrasing terminology into a self-report format. We explored patient understanding of these items via cognitive interviews. Material and method: Sixty patients (33 female, 27 male) undergoing treatment were purposively sampled by age, gender and tumor group (median age 61.5, range 35–84, 12 breast, 12 gynecological, 13 colorectal, 12 lung and 11 renal). Twenty-one PRAE items were completed on a touch-screen computer. Subsequent audio-recorded cognitive interviews and thematic analysis explored patients’ comprehension of items via verbal probing techniques during three interview rounds (n = 20 patients/round). Results: In total 33 item amendments were made; 29% related to question comprehension, 73% response option and 3% order effects. These amendments to phrasing and language improved patient understanding but maintained CTCAE grading and key medical information. Changes were endorsed by members of a patient advisory group (N = 11). Conclusion: Item adaptations resulted in a bank of consistently interpreted self-report AE items for use in future research program. In-depth analysis of items through cognitive interviews is an important step towards developing an internationally valid system for PRAE, thus improving patient safety and experiences during cancer treatment