Hacia la revalorización integral del campesinado

Postula que la revalorización de las culturas campesinas debe ser un proceso de la voluntad política, solidario, y componente esencial del verdadero desarrollo

Política de irrigación: estudio de un proceso de concentración en México

Incluye BibliografíaTrata de establecer el resultado de la politica estatal de irrigacion en Mexico desde 3 perspectivas: la primera la establecen los objetivos enunciados y declarados por quienes formularon e implementaron esa politica; la segunda se refiere al impacto de esos resultados en el desarrollo agricola del pais; y la tercera ubica la exclusion de la mayoria de los productores agricolas de los beneficios de la irrigacion, que absorbe casi toda la inversion y la accion publica en el campo

DESARROLLO CAPITALISTA O CAMPESINO EN EL CAMPO MEXICANO

DESARROLLO CAPITALISTA O CAMPESINO EN EL CAMPO MEXICAN

DESARROLLO CAPITALISTA O CAMPESINO EN EL CAMPO MEXICANO

DESARROLLO CAPITALISTA O CAMPESINO EN EL CAMPO MEXICAN

Fractionated follow-up chemotherapy delays the onset of resistance in bone metastatic prostate cancer

Prostate cancer to bone metastases are almost always lethal. This results from the ability of metastatic prostate cancer cells to co-opt bone remodeling, leading to what is known as the vicious cycle. Understanding how tumor cells can disrupt bone homeostasis through their interactions with the stroma and how metastatic tumors respond to treatment is key to the development of new treatments for what remains an incurable disease. Here we describe an evolutionary game theoretical model of both the homeostatic bone remodeling and its co-option by prostate cancer metastases. This model extends past the evolutionary aspects typically considered in game theoretical models by also including ecological factors such as the physical microenvironment of the bone. Our model recapitulates the current paradigm of the “vicious cycle” driving tumor growth and sheds light on the interactions of heterogeneous tumor cells with the bone microenvironment and treatment response. Our results show that resistant populations naturally become dominant in the metastases under conventional cytotoxic treatment and that novel schedules could be used to better control the tumor and the associated bone disease compared to the current standard of care. Specifically, we introduce fractionated follow up therapy—chemotherapy where dosage is administered initially in one solid block followed by alternating smaller doses and holidays—and argue that it is better than either a continuous application or a periodic one. Furthermore, we also show that different regimens of chemotherapy can lead to different amounts of pathological bone that are known to correlate with poor quality of life for bone metastatic prostate cancer patients