Dinantian Rocks of the Ardfinnan-Mitchelstown Syncline, County Tipperary

Abstract Not Provided

Fungal allergy in asthma-state of the art and research needs

Sensitization to fungi and long term or uncontrolled fungal infection are associated with poor control of asthma, the likelihood of more severe disease and complications such as bronchiectasis and chronic pulmonary aspergillosis. Modelling suggests that >6.5 million people have severe asthma with fungal sensitizations (SAFS), up to 50% of adult asthmatics attending secondary care have fungal sensitization, and an estimated 4.8 million adults have allergic bronchopulmonary aspergillosis (ABPA). There is much uncertainty about which fungi and fungal allergens are relevant to asthma, the natural history of sensitisation to fungi, if there is an exposure response relationship for fungal allergy, and the pathogenesis and frequency of exacerbations and complications. Genetic associations have been described but only weakly linked to phenotypes. The evidence base for most management strategies in ABPA, SAFS and related conditions is weak. Yet straightforward clinical practice guidelines for management are required. The role of environmental monitoring and optimal means of controlling disease to prevent disability and complications are not yet clear. In this paper we set out the key evidence supporting the role of fungal exposure, sensitisation and infection in asthmatics, what is understood about pathogenesis and natural history and identify the numerous areas for research studies

Texture-based Classification for the Automatic Rating of the Perivascular Spaces in Brain MRI

Los espacios perivasculares (EVP) se relacionan con una cognición deficiente, depresión en la edad avanzada, enfermedad de Parkinson, inflamación, hipertensión y enfermedad de pequeños vasos cerebrales, cuando están agrandados y son visibles en imágenes de resonancia magnética (MRI). En este artículo exploramos cómo clasificar la densidad del PVS agrandado en los ganglios basales (BG) mediante la descripción de la textura de la RM cerebral estructural. La textura de la región BG se describe mediante estadísticas de primer orden y características derivadas de la matriz de co-ocurrencia, ambas computadas a partir de la imagen original y los coeficientes producidos por la transformada de wavelet discreta (WSF y WCF, respectivamente), y patrones binarios locales (LBP). Los resultados experimentales con un clasificador de Máquina de vectores de soporte (SVM) muestran que WCF logra una precisión del 80.03%

Automatic Spatial Estimation of White Matter Hyperintensities Evolution in Brain MRI using Disease Evolution Predictor Deep Neural Networks

Funds from the Indonesia Endowment Fund for Education (LPDP), Ministry of Finance, Republic of Indonesia (MFR); Row Fogo Charitable Trust (Grant No. BRO-D.FID3668413)(MCVH); Wellcome Trust (patient recruitment, scanning, primary study Ref No. WT088134/Z/09/A); Fondation Leducq (Perivascular Spaces Transatlantic Network of Excellence); EU Horizon 2020 (SVDs@Target); and the MRC UK Dementia Research Institute at the University of Edinburgh (Wardlaw programme) are gratefully acknowledged. The Titan Xp used for this research was donated by the NVIDIA Corporation.Peer reviewedPublisher PD

The possible causes for sulcal hyperintensities on FLAIR images on brain MRI: the dataset derived from a systematic review

This report describes the data related to the article entitiled: “Relationship between inferior frontal sulcal hyperintensities on brain MRI, ageing and cerebral small vessel disease”. This systematic review was conducted to assess possible causes for sulcal hyperintensities on fluid-attenuated inversion recovery (FLAIR) images on brain MRI