584 research outputs found

    Periodic solutions for a class of second order differential equations

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    New results about the existence of periodic solutions for second order differential equations are provided. The method of proof relies on the Schauder's fixed point theorem. Some examples are presented to illustrate the main results

    Study of Risk Evaluation for Complex Projects under BIM and IPD Collaborative Pattern Based on Neighborhood Rough Sets

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    Faced with the existing problems in the construction industry, project managers have been aware that traditional project delivery patterns cannot satisfy the current building industry\u27s pursuit of high-quality economic benefits or cope with the increasing volume and complexity of modern buildings. Therefore, whole-process comprehensive management has become a new development trend for engineering projects, the traditional project delivery pattern should be changed, and early-stage communication, cooperation, and information sharing among project participants should be strengthened. As for the BIM and IPD collaborative pattern, the emphasis is laid on collaboration among project members, and the core idea lies in benefit and risk sharing and full consideration of human resources, commercial structure and engineering system of projects. The advent of IPD pattern has well solved problematic issues encountered in engineering projects, where risk problem has attracted the highest attention. Risk factors of IPD projects were reduced and screened out based on attribute reduction theory of rough sets, and primary risk factors influencing smooth implementation of IPD projects were obtained

    IP Start-up Control for 300MW Turbine Unit with Bypass System

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    AbstractBased on the analysis of characters of 300MW unit IP start-up, an approach with bypass system about turbine control has been explored in this paper. Control model for IP start-up is given. The pre-warm control of IP start-up and the start-up mode switching are discussed in detail. Control logic for main valve, valve exchanging and bypass system are properly designed. The opening curve of IP regulation valve is given. The schedule is successfully applied in the IP start-up of #8 turbine system, Shalingzi power plant, China. The actually operation results shows that the control logic is right and reasonable. It's available for the system requirements

    Branched-Chain Amino Acid Negatively Regulates KLF15 Expression via PI3K-AKT Pathway.

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    Recent studies have linked branched-chain amino acid (BCAA) with numerous metabolic diseases. However, the molecular basis of BCAA's roles in metabolic regulation remains to be established. KLF15 (Krüppel-like factor 15) is a transcription factor and master regulator of glycemic, lipid, and amino acids metabolism. In the present study, we found high concentrations of BCAA suppressed KLF15 expression while BCAA starvation induced KLF15 expression, suggesting KLF15 expression is negatively controlled by BCAA.Interestingly, BCAA starvation induced PI3K-AKT signaling. KLF15 induction by BCAA starvation was blocked by PI3K and AKT inhibitors, indicating the activation of PI3K-AKT signaling pathway mediated the KLF15 induction. BCAA regulated KLF15 expression at transcriptional level but not post-transcriptional level. However, BCAA starvation failed to increase the KLF15-promoter-driven luciferase expression, suggesting KLF15 promoter activity was not directly controlled by BCAA. Finally, fasting reduced BCAA abundance in mice and KLF15 expression was dramatically induced in muscle and white adipose tissue, but not in liver. Together, these data demonstrated BCAA negatively regulated KLF15 expression, suggesting a novel molecular mechanism underlying BCAA's multiple functions in metabolic regulation

    Multi-point boundary value problems for second-order functional differential equations

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    AbstractThis paper is concerned with the existence of extreme solutions of multi-point boundary value problem for a class of second-order functional differential equations. We introduce a new concept of lower and upper solutions. By using the method of upper and lower solutions and monotone iterative technique, we obtain the existence of extreme solutions
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