Exercise-Induced Changes in Exhaled NO Differentiates Asthma With or Without Fixed Airway Obstruction From COPD With Dynamic Hyperinflation.

Asthmatic patients with fixed airway obstruction (FAO) and patients with chronic obstructive pulmonary disease (COPD) share similarities in terms of irreversible pulmonary function impairment. Exhaled nitric oxide (eNO) has been documented as a marker of airway inflammation in asthma, but not in COPD. To examine whether the basal eNO level and the change after exercise may differentiate asthmatics with FAO from COPD, 27 normal subjects, 60 stable asthmatics, and 62 stable COPD patients were studied. Asthmatics with FAO (n = 29) were defined as showing a postbronchodilator FEV(1)/forced vital capacity (FVC) ≤70% and FEV(1) less than 80% predicted after inhaled salbutamol (400 μg). COPD with dynamic hyperinflation (n = 31) was defined as a decrease in inspiratory capacity (ΔIC%) after a 6 minute walk test (6MWT). Basal levels of eNO were significantly higher in asthmatics and COPD patients compared to normal subjects. The changes in eNO after 6MWT were negatively correlated with the percent change in IC (r = −0.380, n = 29, P = 0.042) in asthmatics with FAO. Their levels of basal eNO correlated with the maximum mid-expiratory flow (MMEF % predicted) before and after 6MWT. In COPD patients with air-trapping, the percent change of eNO was positively correlated to ΔIC% (rs = 0.404, n = 31, P = 0.024). We conclude that asthma with FAO may represent residual inflammation in the airways, while dynamic hyperinflation in COPD may retain NO in the distal airspace. eNO changes after 6MWT may differentiate the subgroups of asthma or COPD patients and will help toward delivery of individualized therapy for airflow obstruction

Health system reforms, violence against doctors and job satisfaction in the medical profession: a cross-sectional survey in Zhejiang Province, Eastern China

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Implementation of a voltage multiplier integrated HID ballast circuit with dimming control for automotive application

Author name used in this publication: K. W. E. ChengAuthor name used in this publication: D. H. WangPower Electronics Research Centre, Department of Electrical Engineering2009-2010 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

An analysis of precipitation isotope distributions across Namibia using historical data

Global precipitation isoscapes based on the Global Network for Isotopes in Precipitation (GNIP) network are an important toolset that aid our understanding of global hydrologiccycles. Although the GNIP database is instrumental in developing global isoscapes, data coverage in some regions of hydrological interest (e.g., drylands) is low or non-existent thus the accuracy and relevance of global isoscapes to these regions is debatable. Capitalizing on existing literature isotope data, we generated rainfall isoscapes for Namibia (dryland) using the cokriging method and compared it to a globally fitted isoscape (GFI) downscaled to country level. Results showed weak correlation between observed and predicted isotope values in the GFI model (r2 < 0.20) while the cokriging isoscape showed stronger correlation (r2 = 0.67). The general trend of the local cokriging isoscape is consistent with synoptic weather systems (i.e., influences from Atlantic Ocean maritime vapour, Indian Ocean maritime vapour, Zaire Air Boundary, the Intertropical Convergence Zone and Tropical Temperate Troughs) and topography affecting the region. However, because we used the unweighted approach in this method, due to data scarcity, the absolute values could beimproved in future studies. A comparison of local meteoric water lines (LMWL) constructed from the cokriging and GFI suggested that the GFI model still reflects the global averageeven when downscaled. The cokriging LMWL was however more consistent with expectations for an arid environment. The results indicate that although not ideal, for data deficientregions such as many drylands, the unweighted cokriging approach using historical local data can be an alternative approach to modelling rainfall isoscapes that are more relevantto the local conditions compared to using downscaled global isoscapes

Comparison and design analysis of pulse transformer for HID ballasts

Author name used in this publication: K. W. E. ChengAuthor name used in this publication: S. L. HoAuthor name used in this publication: X. D. XueRefereed conference paper2005-2006 > Academic research: refereed > Refereed conference paperVersion of RecordPublishe

Air pollution and mortality: Effect modification by personal characteristics and specific cause of death in a case-only study

Short-term effects of air pollution on mortality have been well documented in the literature worldwide. Less is known about which subpopulations are more vulnerable to air pollution. We conducted a case-only study in Hong Kong to examine the potential effect modification by personal characteristics and specific causes of death. Individual information of 402,184 deaths of non-external causes and daily mean concentrations of air pollution were collected from 2001 to 2011. For a 10 μg/m3 increase of pollution concentration, people aged ≥∇65 years (compared with younger ages) had a 0.9–1.8% additional increase in mortality related to PM, NO2, and SO2. People dying from cardiorespiratory diseases (compared with other non-external causes) had a 1.6–2.3% additional increase in PM and NO2 related mortality. Other subgroups that were particularly susceptible were females and those economically inactive. Lower socioeconomic status and causes of cardiorespiratory diseases would increase the likelihood of death associated with air pollution.postprin

Susceptibility of the optic nerve and the involvement of retrograde neuronal degeneration in a delayed radiation induced injury model: evidence from a diffusion tensor imaging study

Animal Models of White Matter Disease & Neurodegeneration: No. 469In the present study, we evaluated changes of multiple white matter tracts following radiation using diffusion tensor imaging. A novel finding of severe changes in FA in the contralateral optic nerve as compared to the ipsilateral optic nerve was observed, and these changes were confirmed by histological evaluation. These findings cannot be explained by difference in radiation dose and suggests, for the first time, an important role of retrograde neuronal degeneration in the underlying mechanism for radiation induced injury to the visual pathway. The results also suggest susceptibility of the optic nerve relative to the cerebral peduncle.postprin

单相多铁性材料 - 极化和磁性序参量的耦合与调控

2007-2008 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

General study on piezoelectric transformer

Author name used in this publication: Cheng K. W. E.Author name used in this publication: Kwok K. W.Power Electronics Research Center, Department of Electrical EngineeringAuthor name used in this publication: Chan H.Refereed conference paper2004-2005 > Academic research: refereed > Refereed conference paperVersion of RecordPublishe

Image processing methods to elucidate spatial characteristics of retinal microglia after optic nerve transection

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