Intelligent optical performance monitor using multi-task learning based artificial neural network

An intelligent optical performance monitor using multi-task learning based artificial neural network (MTL-ANN) is designed for simultaneous OSNR monitoring and modulation format identification (MFI). Signals' amplitude histograms (AHs) after constant module algorithm are selected as the input features for MTL-ANN. The experimental results of 20-Gbaud NRZ-OOK, PAM4 and PAM8 signals demonstrate that MTL-ANN could achieve OSNR monitoring and MFI simultaneously with higher accuracy and stability compared with single-task learning based ANNs (STL-ANNs). The results show an MFI accuracy of 100% and OSNR monitoring root-mean-square error of 0.63 dB for the three modulation formats under consideration. Furthermore, the number of neuron needed for the single MTL-ANN is almost the half of STL-ANN, which enables reduced-complexity optical performance monitoring devices for real-time performance monitoring

UroVysion™ fluorescence in situ hybridization (FISH) possibly has a high positive rate in carcinoma of non-urothelial lineages

Background: Positive UroVysion™ fluorescence in situ hybridization (FISH) is generally considered as urothelial carcinoma (UC). We clarify if UroVysion™ FISH can be positive in carcinoma of non-urothelial lineages (CNUL), and verify the consistency of urine FISH and histological FISH in CNUL.Methods: All CNUL subjects detected by urine FISH assay due to haematuria from Tongji Hospital were screened. Meanwhile, 2 glandular cystitis and 2 urothelial carcinoma were served as negative or positive control. Paraffin-embedded tissue sections of all subjects were sent to the pathology department for histological FISH detection.Results: A total of 27 patients were included in this study, including 9 with adenocarcinomas, 11 with squamous cell carcinomas, and 7 with other tumour types. The overall positive rate in urine FISH was 64.00% (16/25) in patients with CNUL, 77.78% (7/9) in those with adenocarcinoma and 54.55% (6/11) in those with squamous carcinoma. There was a significant difference in the GLP p16 gene deletion rate between UC and CNUL (100% vs. 8.00%, p = 0.017). Histological FISH results showed that the histological results of 19 patients were consistent with their urine FISH results, and only one patient with stage Ⅲa urachal carcinoma had inconsistent histological FISH results (positive) and urine FISH (negative) results.Conclusion: We demonstrated for the first time the application value of FISH in CNUL on urine samples. Positive urine FISH tests indicate not only UC, but also CNUL. UroVysion™ FISH possibly has a high positive rate in CNUL. CNUL and UC have different genetic changes shown by FISH

Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

DataSheet1_UroVysion™ fluorescence in situ hybridization (FISH) possibly has a high positive rate in carcinoma of non-urothelial lineages.PDF

Background: Positive UroVysion™ fluorescence in situ hybridization (FISH) is generally considered as urothelial carcinoma (UC). We clarify if UroVysion™ FISH can be positive in carcinoma of non-urothelial lineages (CNUL), and verify the consistency of urine FISH and histological FISH in CNUL.Methods: All CNUL subjects detected by urine FISH assay due to haematuria from Tongji Hospital were screened. Meanwhile, 2 glandular cystitis and 2 urothelial carcinoma were served as negative or positive control. Paraffin-embedded tissue sections of all subjects were sent to the pathology department for histological FISH detection.Results: A total of 27 patients were included in this study, including 9 with adenocarcinomas, 11 with squamous cell carcinomas, and 7 with other tumour types. The overall positive rate in urine FISH was 64.00% (16/25) in patients with CNUL, 77.78% (7/9) in those with adenocarcinoma and 54.55% (6/11) in those with squamous carcinoma. There was a significant difference in the GLP p16 gene deletion rate between UC and CNUL (100% vs. 8.00%, p = 0.017). Histological FISH results showed that the histological results of 19 patients were consistent with their urine FISH results, and only one patient with stage Ⅲa urachal carcinoma had inconsistent histological FISH results (positive) and urine FISH (negative) results.Conclusion: We demonstrated for the first time the application value of FISH in CNUL on urine samples. Positive urine FISH tests indicate not only UC, but also CNUL. UroVysion™ FISH possibly has a high positive rate in CNUL. CNUL and UC have different genetic changes shown by FISH.</p

Feasibility demonstration of space-division-multiplexed transmission of IEEE 802.11n/ac-compliant MIMO signals over OM3 multimode fiber

Using commercial IEEE 802.11n/ac access points, the feasibility of 3×3 space-division-multiplexed MIMO transmission over a single OM3 multimode fiber is experimentally demonstrated. More than two-fold multiplexing gain is realized for up to 1km fiber length with a tight fiber bend radius of 2mm

Feasibility demonstration of space-division-multiplexed transmission of IEEE 802.11n/ac-compliant MIMO signals over OM3 multimode fiber

Using commercial IEEE 802.11n/ac access points, the feasibility of 3×3 space-division-multiplexed MIMO transmission over a single OM3 multimode fiber is experimentally demonstrated. More than two-fold multiplexing gain is realized for up to 1km fiber length with a tight fiber bend radius of 2mm

Feasibility of space-division-multiplexed transmission of IEEE 802.11 n/ac-compliant wireless MIMO signals over OM3 multimode fiber

\u3cp\u3eIn this paper, we have experimentally demonstrated the feasibility of space-division-multiplexed 3 × 3 multiple-input multiple-output (MIMO) transmission over a single OM3 multimode fiber (MMF) using commercial IEEE 802.11 n/ac access points. Throughput performance for different fiber length links under a range of fiber bending conditions was evaluated. To study the throughput improvement by MIMO technology, throughput performance of single-input single-output (SISO), 2 × 2 MIMO and 3 × 3 MIMO over separate SMF links was also measured for comparison. It is shown that, spatially-multiplexed MMF channel with 3 × 3 MIMO configuration could provide a significant throughput increase in comparison with SISO and 2 × 2 MIMO SMFs configurations, and present a comparable performance with 3 × 3 MIMO SMFs configuration. Meanwhile, the analyses of the impact of fiber bending indicate that, even under a tight fiber bending radius as low as 2 mm, the system performance could still keep at an acceptable level. With all fiber bending radii tested, within each 5-min measurement time, the fiber channel is found to be good enough to provide throughput greater than twice the average SISO value for more than 87.66% and 72.72% of the time, at the 2.4 and 5 GHz bands, respectively. These results together point out a very simple and cost-saving solution for future in-building DASs to distribute wireless MIMO signals using commercially-available MMF infrastructure by space division multiplexing technique, even though it may encounter tight bending conditions.\u3c/p\u3