169 research outputs found
Improved effects of word‐retrieval treatments subsequent to addition of the orthographic form
Separation quality of a geometric ratchet
We consider an experimentally relevant model of a geometric ratchet in which
particles undergo drift and diffusive motion in a two-dimensional periodic
array of obstacles, and which is used for the continuous separation of
particles subject to different forces. The macroscopic drift velocity and
diffusion tensor are calculated by a Monte-Carlo simulation and by a
master-equation approach, using the correponding microscopic quantities and the
shape of the obstacles as input. We define a measure of separation quality and
investigate its dependence on the applied force and the shape of the obstacles
Conversational Discourse of Aphasic and Normal Adults: An Analysis of Communicative Functions
TB
Rectification and Phase Locking for Particles on Two Dimensional Periodic Substrates
We show that a novel rectification phenomena is possible for overdamped
particles interacting with a 2D periodic substrate and driven with a
longitudinal DC drive and a circular AC drive. As a function of DC amplitude,
the longitudinal velocity increases in a series of quantized steps with
transverse rectification occuring near these transitions. We present a simple
model that captures the quantization and rectification behaviors.Comment: 4 pages, 4 postscript figure
Superconducting Fluxon Pumps and Lenses
We study stochastic transport of fluxons in superconductors by alternating
current (AC) rectification. Our simulated system provides a fluxon pump,
"lens", or fluxon "rectifier" because the applied electrical AC is transformed
into a net DC motion of fluxons. Thermal fluctuations and the asymmetry of the
ratchet channel walls induce this "diode" effect, which can have important
applications in devices, like SQUID magnetometers, and for fluxon optics,
including convex and concave fluxon lenses. Certain features are unique to this
novel two-dimensional (2D) geometric pump, and different from the previously
studied 1D ratchets.Comment: Phys. Rev. Lett. 83, in press (1999); 4 pages, 5 .gif figures;
figures also available at http://www-personal.engin.umich.edu/~nori/ratche
GRADE Guidelines 30: the GRADE approach to assessing the certainty of modeled evidence—An overview in the context of health decision-making
Objectives:
The objective of the study is to present the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) conceptual approach to the assessment of certainty of evidence from modeling studies (i.e., certainty associated with model outputs). /
Study Design and Setting:
Expert consultations and an international multidisciplinary workshop informed development of a conceptual approach to assessing the certainty of evidence from models within the context of systematic reviews, health technology assessments, and health care decisions. The discussions also clarified selected concepts and terminology used in the GRADE approach and by the modeling community. Feedback from experts in a broad range of modeling and health care disciplines addressed the content validity of the approach. /
Results:
Workshop participants agreed that the domains determining the certainty of evidence previously identified in the GRADE approach (risk of bias, indirectness, inconsistency, imprecision, reporting bias, magnitude of an effect, dose–response relation, and the direction of residual confounding) also apply when assessing the certainty of evidence from models. The assessment depends on the nature of model inputs and the model itself and on whether one is evaluating evidence from a single model or multiple models. We propose a framework for selecting the best available evidence from models: 1) developing de novo, a model specific to the situation of interest, 2) identifying an existing model, the outputs of which provide the highest certainty evidence for the situation of interest, either “off-the-shelf” or after adaptation, and 3) using outputs from multiple models. We also present a summary of preferred terminology to facilitate communication among modeling and health care disciplines. /
Conclusion:
This conceptual GRADE approach provides a framework for using evidence from models in health decision-making and the assessment of certainty of evidence from a model or models. The GRADE Working Group and the modeling community are currently developing the detailed methods and related guidance for assessing specific domains determining the certainty of evidence from models across health care–related disciplines (e.g., therapeutic decision-making, toxicology, environmental health, and health economics)
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