The "backdoor pathway" of androgen synthesis in human male sexual development.

Mammalian sex determination (male versus female) is largely controlled by genes, whereas sex differentiation (development of reproductive structures) is largely controlled by hormones. Work in the 20th century indicated that female external anatomy was a "default" pathway of development not requiring steroids, whereas male genital development required testicular testosterone plus dihydrotestosterone (DHT) made in genital skin according to a "classic" pathway. Recent work added the description of an alternative "backdoor" pathway of androgen synthesis discovered in marsupials. Unique "backdoor steroids" are found in human hyperandrogenic disorders, and genetic disruption of the pathway causes disordered male sexual development, suggesting it plays an essential role. O'Shaughnessy and colleagues now show that the principal human backdoor androgen is androsterone and provide strong evidence that it derives from placental progesterone that is metabolized to androsterone in nontesticular tissues. These studies are essential to understanding human sexual development and its disorders

Results of TC-1 boost pump icing tests in the space power facility

A series of tests were conducted in the space power facility to investigate the failure of the Centaur oxidizer boost pump during the Titan/Centaur proof flight February 11, 1974. The three basic objectives of the tests were: (1) demonstrate if an evaporative freezing type failure mechanism could have prevented the pump from operating, (2) determine if steam from the exhaust of one of the attitude control engine could have entered a pump seal cavity and caused the failure, and (3) obtain data on the heating effects of the exhaust plume from a hydrogen peroxide attitude control engine

Initial test results with a single-cylinder rhombic-drive Stirling engine

A 6 kW (8 hp), single-cylinder, rhombic-drive Stirling engine was restored to operating condition, and preliminary characterization tests run with hydrogen and helium as the working gases. Initial tests show the engine brake specific fuel consumption (BSFC) with hydrogen working gas to be within the range of BSFC observed by the Army at Fort Belvoir, Virginia, in 1966. The minimum system specific fuel consumption (SFC) observed during the initial tests with hydrogen was 669 g/kW hr (1.1 lb/hpx hr), compared with 620 g/kWx hr (1.02 lb/hpx hr) for the Army tests. However, the engine output power for a given mean compression-space pressure was lower than for the Army tests. The observed output power at a working-space pressure of 5 MPa (725 psig) was 3.27 kW (4.39 hp) for the initial tests and 3.80 kW (5.09 hp) for the Army tests. As expected, the engine power with helium was substantially lower than with hydrogen

Economic profile of Florida's marine life industry

The marine life industry in Florida is defined as the harvest of live marine specimens (fish and invertebrate species including plants, live rock and sand, and small “critters”) for commercial use, primarily aquariums. This paper summarizes data collected on the industry since 1990, including total landings, revenues, and trends over time. Regional analysis shows where the primary collecting areas are located in Florida. Seasonal analysis shows when the majority of landings occur within the year. Statistics on the number of participants by type (i.e., collector versus wholesaler) provide insight into the size of the industry. Trends are evaluated in terms of changes across the 9-year period from 1990 to 1998. In general, the number of licensed collectors has increased substantially, landings of fish and animal invertebrates peaked in 1994, angelfish dominated the fish landings, live rock dominated the invertebrate landings, and the average landings per trip have remained relatively constant. (67pp.

Mechanical and Chemical Control of Smooth Cordgrass in Waillapa Bay, Washington

We evaluated four methods to control smooth cordgrass (Spartina alterniflora Loisel), hereafter spartina, in Willapa Bay, Washington: mowing, mowing plus herbicide combination, herbicide only for clones, and aerial application of herbicide for meadows. (PDF has 7 pages.

1999 US tropical fish wholesaler survey: results and implications

A survey of marine life wholesalers was initiated in 1999 as a first step towards understanding the nature of Florida’s marine life industry, the demand for Florida products, and the need for changes in the way the industry is regulated. Florida firms deal primarily in marine species and collect much of their own product. Wholesalers outside of Florida handle more freshwater species and purchase most of their inventory, the majority from overseas suppliers. Dealers predict that the average firm size will continue to grow as the industry consolidates. Niche markets for eco-friendly product will gain momentum. In Florida, marketing strategies should point to the high quality of Florida species with emphasis on the growing popularity of invertebrates. Wholesalers should look to provide buyers of Florida product with more consistent quantities throughout the year. Resource managers will be challenged to find ways to protect over-harvested species without interfering with the collection of abundant species while considering the effect of new regulations. (42pp.