Sets of Priors Reflecting Prior-Data Conflict and Agreement

In Bayesian statistics, the choice of prior distribution is often debatable, especially if prior knowledge is limited or data are scarce. In imprecise probability, sets of priors are used to accurately model and reflect prior knowledge. This has the advantage that prior-data conflict sensitivity can be modelled: Ranges of posterior inferences should be larger when prior and data are in conflict. We propose a new method for generating prior sets which, in addition to prior-data conflict sensitivity, allows to reflect strong prior-data agreement by decreased posterior imprecision.Comment: 12 pages, 6 figures, In: Paulo Joao Carvalho et al. (eds.), IPMU 2016: Proceedings of the 16th International Conference on Information Processing and Management of Uncertainty in Knowledge-Based Systems, Eindhoven, The Netherland

Influence of gaseous hydrogen on metals Interim report

Gaseous hydrogen embrittlement in Inconel 718, Inconel 625, AISI 321 stainless steel, Ti-5Al-25Sn ELI, and OFHC coppe

A High-Resolution Rotation Curve of NGC 6822: A Test-case for Cold Dark Matter

We present high resolution rotation curves of the local group dwarf irregular galaxy NGC 6822 obtained with the Australia Telescope Compact Array. Our best curves have an angular resolution of 8'' or 20 pc and contain some 250 independent points. The stellar and gas components of NGC 6822 cannot explain the shape of the curve, except for the very inner regions, and NGC 6822 is consequently very dark matter dominated. There is no evidence for the presence of a steep density cusp down to scales of ~20 pc, contrary to the predictions of Cold Dark Matter.Comment: Accepted for publication in MNRA

The Green Studio Handbook: Environmental Strategies for Schematic Design

In design studio projects we often see schemes with inspired, yet unvalidated, gestural sketches related to wishful green strategies. Yellow and blue magic arrows represent hypotheses about the behavior of daylight and/or air flow in and about buildings. This paper provides an overview of The Green Studio Handbook, recently published as a resource for designers seeking clear guidelines for integrating green design strategies into the conceptual and schematic phases of design. The book contains a discussion of the integration of green strategies and how building form, orientation, and spatial layout are critical to the proper performance of certain green strategies; 40 green design strategies in six broad topic areas, each providing acatalog of information for common strategies that must be implemented at the schematic design phase; and nine case studies that show how various green strategies work together in a finished building. This paper provides excerpts of several design strategies and one case study and suggests a variety of ways that the book may be used.Keywords: green design, case studies, education, schematic desig

An unfolded protein-induced conformational switch activates mammalian IRE1.

The unfolded protein response (UPR) adjusts the cell's protein folding capacity in the endoplasmic reticulum (ER) according to need. IRE1 is the most conserved UPR sensor in eukaryotic cells. It has remained controversial, however, whether mammalian and yeast IRE1 use a common mechanism for ER stress sensing. Here, we show that similar to yeast, human IRE1α's ER-lumenal domain (hIRE1α LD) binds peptides with a characteristic amino acid bias. Peptides and unfolded proteins bind to hIRE1α LD's MHC-like groove and induce allosteric changes that lead to its oligomerization. Mutation of a hydrophobic patch at the oligomerization interface decoupled peptide binding to hIRE1α LD from its oligomerization, yet retained peptide-induced allosteric coupling within the domain. Importantly, impairing oligomerization of hIRE1α LD abolished IRE1's activity in living cells. Our results provide evidence for a unifying mechanism of IRE1 activation that relies on unfolded protein binding-induced oligomerization

The Enigmatic Radio Afterglow of GRB 991216

We present wide-band radio observations spanning from 1.4 GHz to 350 GHz of the afterglow of GRB 991216, taken from 1 to 80 days after the burst. The optical and X-ray afterglow of this burst were fairly typical and are explained by a jet fireball. In contrast, the radio light curve is unusual in two respects: (a) the radio light curve does not show the usual rise to maximum flux on timescales of weeks and instead appears to be declining already on day 1 and (b) the power law indices show significant steepening from the radio through the X-ray bands. We show that the standard fireball model, in which the afterglow is from a forward shock, is unable to account for (b) and we conclude that the bulk of the radio emission must arise from a different source. We consider two models, neither of which can be ruled out with the existing data. In the first (conventional) model, the early radio emission is attributed to emission from the reverse shock as in the case of GRB 990123. We predict that the prompt optical emission would have been as bright (or brighter) than 8th magnitude. In the second (exotic) model, the radio emission originates from the forward shock of an isotropically energetic fireball (10^54 erg) expanding into a tenuous medium (10^-4 cm^-3). The resulting fireball would remain relativistic for months and is potentially resolvable with VLBI techniques. Finally, we note that the near-IR bump of the afterglow is similar to that seen in GRB 971214 and no fireball model can explain this bump.Comment: ApJ, submitte

Analysis of V-G Records from the SNB-1 Airplane

Availability data obtained on SNB-1 trainer-class airplanes were analyzed and results presented as flight envelopes which predict occurrences of large values of air speed and acceleration. Comparison is made with SNJ-4 trainer-class airplane data analyzed by the same method. It is concluded that flight envelopes are satisfactory; that the two types show large differences in flight loads and speeds experience; and that SNB-1 will seldom, if ever, exceed design limit load factor and restricted speed, which SNJ-4 can be expected to exceed design-limit load factor and restricted speed in a very small number of flight hours

Ocular genetics in the genomics age

Current genetic screening methods for inherited eye diseases are concentrated on the coding exons of known disease genes (gene panels, clinical exome). These tests have a variable and often limited diagnostic rate depending on the clinical presentation, size of the gene panel and our understanding of the inheritance of the disorder (with examples described in this issue). There are numerous possible explanations for the missing heritability of these cases including undetected variants within the relevant gene (intronic, up/down‐stream and structural variants), variants harbored in genes outside the targeted panel, intergenic variants, variants undetectable by the applied technology, complex/non‐Mendelian inheritance, and nongenetic phenocopies. In this article we further explore and review methods to investigate these sources of missing heritability