Cover Crop Productivity in Contrasting Growing Conditions and Influence on the Subsequent Crop

In arable systems, cover crops provide multiple ecosystem services involved in soil protection and fertility. They can efficiently compete against weeds, control erosion or recycle nutrients. The supply of these services is however largely dependent on cover crop growth as most of the services are related to biomass production. The choice of a cover crop adapted to the growing conditions is thus essential. Growing mixtures instead of sole crops is expected to be a way to overcome variable growing conditions and to insure high biomass production.Different field trials have been conducted from 2013 to 2016 in Nyon, Switzerland to assess cover crop biomass production and stability, and their influence on the following crop. Indian mustard, field pea, black oat and phacelia were sown as sole crops and in mixtures with different diversity levels (2, 3 and 4 species). A mixture of 11 species (50% of legumes and 50% of other species) was also tested. Biomass production was assessed about three months after seeding, just before the seeding of the next main crop, in two 0.5 m × 0.5 m quadrats. For each cover crop, a risk of failure, e.g. the probability of producing less than 3 t/ha (minimal biomass allowing to provide the services expected from cover crops), was estimated. Weed pressure was appraised by weed biomass in quadrats. The yield of the following main crop, here winter wheat, was determined after harvesting with a combine harvester, at wheat maturity, in summer. Sole crops showed very contrasting performance according to the growing conditions. Pea was the most productive in low yielding conditions with 2 t/ha while other sole crops produced only 0.5 t/ha. Pea was barely more productive in high yielding conditions, reaching only 3 t/ha when cover crop average was 6 t/ha. By contrast, mustard and oat showed high production potential in these conditions, exceeding 7 t/ha. Pea should thus be favoured when the growing conditions are clearly identified as limiting (low N availability), while oat or mustard should be chosen in favourable conditions. However, in general, conditions are hardly predictable. Our results showed that mixtures should be preferred as they were adapted to a wider range of environments than sole crops, performing well regardless of the conditions and resulting in a lower risk of failure than sole crops. The 11-specie mixture revealed that generally 4 to 5 species are sufficient to insure a good performance regardless of the conditions. Regarding cover crop effect on the following crop, we evidenced the importance of high biomass production for efficient weed control and positive influence on crop yield in no till treatments.Our results showed that cover crop mixtures rather than sole crops should be chosen as they insure high biomass production and thus a good supply of ecosystem services. In addition, cover crop cultivation, even for a short period, proved to be paramount to the maintenance of grain yield and soil fertility on the long term, especially in reduced tillage systems

Specific interactions leading to transgressive overyielding in cover crop mixtures

Growing mixtures of species instead of sole crops is expected to increase the ecosystem services provided by cover crops. This study aimed at understanding the interactions between species and investigating how they affect the performance of the mixture. Four species were combined in six bispecific mixtures in a field experiment. The performance of each species when grown in a mixture was compared to its performance as a sole crop at different sowing densities, to characterise the influence of intra- and interspecific competition for each species. Intra- and interspecific competition coefficients were quantified using a response surface design and the hyperbolic yield-density equation. Interactions between the four species ranged from facilitation to competition. Most of the mixtures exhibited transgressive overyielding. Without nitrogen (N) fertilisation, high complementarity between species allowed to achieve the highest biomass. With N fertilisation, high dominance of one mixture component should be avoided to achieve good performance. A revised approach in the use of the land equivalent ratio for the evaluation of cover crop mixtures is also proposed in this study. It allows to better identify transgressive overyielding in mixtures and to better characterise the effect of one species on the other within the mixture

Asymptomatic Malaria Prevalence and Health Facility Influence on the Attitude of Facility Users in Malaria Meso-Endemic Districts in Ghana

Asymptomatic adults are a regular pool for malaria transmission because of their roles as parasite reservoirs of infection. This study aimed to assess activities at various healthcare facilities that could influence the health seeking attitudes of facility users and to determine malaria infection status of ‘healthy’ adults who accompanied ill relations to selected health facilities. The descriptive, cross-sectional study employed cluster-probability sampling technique to recruit 849 participants from seven districts in malaria meso-endemic forest zone of Ghana. Questionnaires were administered and capillary blood samples were taken for malaria diagnostic tests. While 51.6% had their expectations fully met, 48.4% were dissatisfied because of delays, poor attitude of healthcare staff and hidden charges. Asymptomatic malaria prevalence was 13.1% (111 out of 849). Facility-related challenges can impede access and affect the health-seeking behaviour of potential clients to a health facility. Client satisfaction may not only be limited to clinical effectiveness, so healthcare facilities should consider socio-psychological acceptability and perceptions as well as proactive screening to reduce the menace of malaria infection reservoir

Effect of species identity and diversity on biomass production and its stability in cover crop mixtures

Thanks to positive interactions between species, growing mixtures of cover crops allows improving the ecosystem services provided by cover crop cultivation. In this study, the influence of species diversity but also of species identity and mixture composition on cover crop biomass production and its stability in diverse growing conditions was studied. Several field experiments (varying soil type, preceding crop, soil tillage, sowing density, nitrogen fertilization and spatial replication) were set up in Switzerland during the period 2013−2016. In these experiments the performance of cover crop species grown as sole crops was compared to that of multispecific mixtures. Part of these experiments followed a simplex design in which four cover crop species were combined together with different proportions, producing a total of 25 mixtures of varied diversity. The other experiments compared sole crop and mixture biomass production in standard randomised block or split plot experiments. Globally, mixtures tended to produce slightly more biomass than the sole crops, with an average between 2 t/ ha and 3.2 t/ha for sole crops and of about 3.5 t/ha for mixtures. Overyielding as well as transgressive overyielding were observed, in 81% and 37% of the cases on average, respectively. However no effect of the level of species diversity within mixtures could be found. Biomass production of cover crops was highly influenced by their growing conditions and by the identity of the species involved, especially for sole crops and bispecific mixtures. The analyses of the simplex experiments allowed to show that species interactions played an important role in biomass production in 7 out of 15 growing conditions, even for a short growing period of about three months. Most of the cover crop mixtures with the highest biomass production had a rather low diversity, i.e. about two species on average, but the identity of the species involved in these mixtures depended on the growing conditions. Our results do not show a strong diversity effect on the biomass production of cover crop mixtures cultivated for a short growing period, but a stronger effect of species identity and of the growing conditions. Mixtures with low diversity generally outcompete more diverse mixtures, but more diverse mixtures offer an insurance effect given the unpredictability of growing conditions during cover crop cultivation

Prospective Study of Bowel Movement, Laxative Use, and Risk of Colorectal Cancer among Women

The authors prospectively examined the association between bowel movement frequency, laxative use, and the risk of colorectal cancer in 84, 577 women of the Nurses' Health Study living in the United States, 36-61 years of age and free of cancer in 1982. Between 1984 and 1996, 611 incident cases of colorectal cancer were documented. After controlling for age, body mass index, fiber intake, postmenopausal status and hormone use, physical activity, and use of laxatives, the relative risks associated with having bowel movements every third day or less, compared with those with bowel movements once daily, were 0.94 (95% confidence interval (Cl): 0.69, 1.28) for colorectal cancer, 0.88 (95% Cl: 0.62, 1.26) for colon cancer, and 1.18 (95% Cl: 0.63, 2.20) for rectal cancer. Compared with women who never used laxatives, the multivariate relative risks associated with weekly to daily laxative use were 1.00 (95% Cl: 0.72, 1.40) for colorectal cancer, 1.09 (95% Cl: 0.76, 1.57) for colon cancer, and 0.68 (95% Cl: 0.29, 1.57) for rectal cancer. These findings do not support an association between infrequent bowel movement, laxative use, and risk of colorectal cancer and indicate that simple questions directed at bowel movement frequency are unlikely to enhance our ability to predict colorectal cancer risk. Am J Epidemiol2000; 151: 958-6

The epidemiology of lymphatic filariasis in Ghana, explained by the possible existence of two strains of Wuchereria bancrofti

Introduction Lymphatic filariasis is a debilitating disease caused by the filarial worm Wuchereria bancrofti. It is earmarked for elimination by the year 2020 through the Global Program for the Elimination of LF (GPELF). In Ghana, mass treatment has been on-going since the year 2000. Earlier studies have revealed differing epidemiology of LF in the North and South of Ghana. This study was therefore aimed at understanding the possible impacts of W. bancrofti diversity on the epidemiology and control of LF in Ghana. Methods The Mitochondrial, Cytochrome C Oxidase I gene of W. bancrofti samples was sequenced and analyzed. The test sequences were grouped into infrapopulations, and pairwise differences (Π) and mutation rates (θ) were computed. The amount of variance within and among populations was also computed using the AMOVA. The evolutionary history was inferred using the Maximum Parsimony method. Results Seven samples from the South and 15 samples from the North were sequenced, and submitted to GenBank with accession numbers GQ479497- GQ479518. The results revealed higher mutation frequencies in the southern population, compared to the northern population. Haplotype analyses revealed a total of 11 haplotypes (Hap) in all the 22 DNA sequences, with high genetic variation and polymorphisms within the southern samples. Conclusion This study showed that there is considerable genetic variability within W. bancrofti populations in Ghana, differences that might explain the observed epidemiology of LF. Further studies are however required for an in-depth understanding of LF epidemiology and control

The Society for Immunotherapy of Cancer perspective on regulation of interleukin-6 signaling in COVID-19-related systemic inflammatory response

The pandemic caused by the novel coronavirus SARS-CoV-2 has placed an unprecedented burden on healthcare systems around the world. In patients who experience severe disease, acute respiratory distress is often accompanied by a pathological immune reaction, sometimes referred to as ‘cytokine storm’. One hallmark feature of the profound inflammatory state seen in patients with COVID-19 who succumb to pneumonia and hypoxia is marked elevation of serum cytokines, especially interferon gamma, tumor necrosis factor alpha, interleukin 17 (IL-17), interleukin 8 (IL-8) and interleukin 6 (IL-6). Initial experience from the outbreaks in Italy, China and the USA has anecdotally demonstrated improved outcomes for critically ill patients with COVID-19 with the administration of cytokine-modulatory therapies, especially anti-IL-6 agents. Although ongoing trials are investigating anti-IL-6 therapies, access to these therapies is a concern, especially as the numbers of cases worldwide continue to climb. An immunology-informed approach may help identify alternative agents to modulate the pathological inflammation seen in patients with COVID-19. Drawing on extensive experience administering these and other immune-modulating therapies, the Society for Immunotherapy of Cancer offers this perspective on potential alternatives to anti-IL-6 that may also warrant consideration for management of the systemic inflammatory response and pulmonary compromise that can be seen in patients with severe COVID-19

The CO-to-H2 Conversion Factor From Infrared Dust Emission Across the Local Group

We estimate the conversion factor relating CO emission to H2 mass, alpha_CO, in five Local Group galaxies that span approximately an order of magnitude in metallicity - M31, M 33, the Large Magellanic Cloud (LMC), NGC 6822, and the Small Magellanic Cloud (SMC). We model the dust mass along the line of sight from infrared (IR) emission and then solve for the alpha_CO that best allows a single gas-to-dust ratio (delta_GDR) to describe each system. This approach remains sensitive to CO-dark envelopes of H2 surrounding molecular clouds. In M 31, M 33, and the LMC we find alpha_CO \approx 3-9 M_sun pc^-2 (K km s^-1)^-1, consistent with the Milky Way value within the uncertainties. The two lowest metallicity galaxies in our sample, NGC 6822 and the SMC (12 + log(O/H) \approx 8.2 and 8.0), exhibit a much higher alpha_CO. Our best estimates are \alpha_NGC6822 \approx 30 M_sun/pc^-2 (K km s^-1)^-1 and \alpha_SMC \approx 70 M_sun/pc^-2 (K km s-1)-1. These results are consistent with the conversion factor becoming CO a strong function of metallicity around 12 + log(O/H) \sim 8.4 - 8.2. We favor an interpretation where decreased dust-shielding leads to the dominance of CO-free envelopes around molecular clouds below this metallicity.Comment: Accepted for publication in the Astrophysical Journal, 15 pages, 7 figure