A unified phenomenological model for tensile and compressive response of polymeric foams

Tensile and compressive stress-strain responses were obtained for various densities of polymer foams. These experimental data were used to determine relevant engineering parameters (such as elastic moduli in tension and compression, ultimate tensile strength, etc.) as a function of foam density. A phenomenological model applicable for both compressive and tensile responses of polymeric foams is validated by comparing the model to the experimentally obtained compression and tensile responses. The model parameters were analyzed to determine the effect of each parameter on the mechanical response of the foam. The engineering parameters were later compared to the appropriate model parameters and a good correlation was obtained. It was shown that the model indeed captures the entire compressive and tensile response of polymeric foams effectively

Contributions of individual variation in temperature, solar radiation and precipitation to crop yield in the North China Plain, 1961–2003

An understanding of the relative impacts of the changes in climate variables on crop yield can help develop effective adaptation strategies to cope with climate change. This study was conducted to investigate the effects of the interannual variability and trends in temperature, solar radiation and precipitation during 1961–2003 on wheat and maize yields in a double cropping system at Beijing and Zhengzhou in the North China Plain (NCP), and to examine the relative contributions of each climate variable in isolation. 129 climate scenarios consisting of all the combinations of these climate variables were constructed. Each scenario contained 43 years of observed values of one variable, combined with values of the other two variables from each individual year repeated 43 times. The Agricultural Production Systems Simulator (APSIM) was used to simulate crop yields using the ensemble of generated climate scenarios. The results showed that the warming trend during the study period did not have significant impact on wheat yield potential at both sites, and only had significant negative impact on maize yield potential at Beijing. This is in contrast with previous results on effect of warming. The decreasing trend in solar radiation had a much greater impact on simulated yields of both wheat and maize crops, causing a significant reduction in potential yield of wheat and maize at Beijing. Although decreasing trends in rainfed yield of both simulated wheat and maize were found, the substantial interannual variability of precipitation made the trends less prominent

Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease

Prion diseases are fatal, transmissible, neurodegenerative diseases caused by the misfolding of the prion protein (PrP). At present, the molecular pathways underlying prion-mediated neurotoxicity are largely unknown. We hypothesized that the transcriptional regulator of the stress response, heat shock factor 1 (HSF1), would play an important role in prion disease. Uninoculated HSF1 knockout (KO) mice used in our study do not show signs of neurodegeneration as assessed by survival, motor performance, or histopathology. When inoculated with Rocky Mountain Laboratory (RML) prions HSF1 KO mice had a dramatically shortened lifespan, succumbing to disease ≈20% faster than controls. Surprisingly, both the onset of home-cage behavioral symptoms and pathological alterations occurred at a similar time in HSF1 KO and control mice. The accumulation of proteinase K (PK)-resistant PrP also occurred with similar kinetics and prion infectivity accrued at an equal or slower rate. Thus, HSF1 provides an important protective function that is specifically manifest after the onset of behavioral symptoms of prion disease

Solid friction between soft filaments

Any macroscopic deformation of a filamentous bundle is necessarily accompanied by local sliding and/or stretching of the constituent filaments. Yet the nature of the sliding friction between two aligned filaments interacting through multiple contacts remains largely unexplored. Here, by directly measuring the sliding forces between two bundled F-actin filaments, we show that these frictional forces are unexpectedly large, scale logarithmically with sliding velocity as in solid-like friction, and exhibit complex dependence on the filaments' overlap length. We also show that a reduction of the frictional force by orders of magnitude, associated with a transition from solid-like friction to Stokes' drag, can be induced by coating F-actin with polymeric brushes. Furthermore, we observe similar transitions in filamentous microtubules and bacterial flagella. Our findings demonstrate how altering a filament's elasticity, structure and interactions can be used to engineer interfilament friction and thus tune the properties of fibrous composite materials

Vertebral arteries do not experience tensile force during manual cervical spine manipulation applied to human cadavers

Background: The vertebral artery (VA) may be stretched and subsequently damaged during manual cervical spine manipulation. The objective of this study was to measure VA length changes that occur during cervical spine manipulation and to compare these to the VA failure length. Methods: Piezoelectric ultrasound crystals were implanted along the length of the VA (C1 to C7) and were used to measure length changes during cervical spine manipulation of seven un-embalmed, post-rigor human cadavers. Arteries were then excised, and elongation from arbitrary in-situ head/neck positions to first force (0.1 N) was measured. Following this, VA were stretched (8.33 mm/s) to mechanical failure. Failure was defined as the instance when VA elongation resulted in a decrease in force. Results: From arbitrary in-situ head/neck positions, the greatest average VA length change during spinal manipulation was [mean (range)] 5.1% (1.1 to 15.1%). From arbitrary in-situ head/neck positions, arteries were elongated on average 33.5% (4.6 to 84.6%) prior to first force occurrence and 51.3% (16.3 to 105.1%) to failure. Average failure forces were 3.4 N (1.4 to 9.7 N). Conclusions: Measured in arbitrary in-situ head/neck positions, VA were slack. It appears that this slack must be taken up prior to VA experiencing tensile force. During cervical spine manipulations (using cervical spine extension and rotation), arterial length changes remained below that slack length, suggesting that VA elongated but were not stretched during the manipulation. However, in order to answer the question if cervical spine manipulation is safe from a mechanical perspective, the testing performed here needs to be repeated using a defined in-situ head/neck position and take into consideration other structures (e.g. carotid arteries). Keywords: Spinal biomechanics; cerebrovascular accidents; spinal manipulation; stroke; vertebral artery dissection

The Physical Basis for Predicting Atlantic Sector Seasonal-to-Interannual Climate Variability

This paper reviews the observational and theoretical basis for the prediction of seasonal-to-interannual (S/I) climate variability in the Atlantic sector. The emphasis is on the large-scale picture rather than on regional details. The paper is divided into two main parts: a discussion of the predictability of the North Atlantic Oscillation (NAO)—the dominant pattern of variability in the North Atlantic—and a review of the tropical Atlantic prediction problem. The remote effects of El Niño are also mentioned as an important factor in Atlantic climate variability. Only a brief discussion is provided on the subject of South Atlantic climate predictability. Because of its chaotic dynamical nature, the NAO and its related rainfall and temperature variability, while highly significant over Europe and North America, are largely unpredictable. This also affects the predictive skill over the tropical Atlantic, because the NAO interferes with the remote influence of El Niño. That said, there appears to be an insufficiently understood, marginal signal in the NAO behavior that may be predictable and thus useful to certain end users. It is manifested in the deviation of the NAO temporal behavior from first-order autoregressive behavior. Tropical Atlantic climate variability centers on the sensitivity of the marine ITCZ to remote forcing from the equatorial Pacific and interactions with underlying sea surface temperature (SST) variability. Both mechanisms are potentially predictable—that is, given the underlying SSTs and the strength of El Niño, one could determine with a high degree of skill the anomalies in ITCZ position and intensity. However, local SSTs are easily affected by largely unpredictable North and South Atlantic phenomena, such as the NAO. In addition, the local ocean–atmosphere coupling in the Atlantic acts on relatively short time scales. Thus, in reality the level of skill indicated by forced model simulations are difficult to achieve. The use of coupled models may improve the prospects of tropical Atlantic prediction

Warren McCulloch and the British cyberneticians

Warren McCulloch was a significant influence on a number of British cyberneticians, as some British pioneers in this area were on him. He interacted regularly with most of the main figures on the British cybernetics scene, forming close friendships and collaborations with several, as well as mentoring others. Many of these interactions stemmed from a 1949 visit to London during which he gave the opening talk at the inaugural meeting of the Ratio Club, a gathering of brilliant, mainly young, British scientists working in areas related to cybernetics. This paper traces some of these relationships and interaction