Exercise intensity-dependent effects of arm and leg-cycling on cognitive performance

Physiological responses to arm and leg-cycling are different, which may influence psychological and biological mechanisms that influence post-exercise cognitive performance. The aim of this study was to determine the effects of maximal and submaximal (absolute and relative intensity matched) arm and leg-cycling on executive function. Thirteen males (age, 24.7 ± 5.0 years) initially undertook two incremental exercise tests to volitional exhaustion for arm-cycling (82 ± 18 W) and leg-cycling (243 ± 52 W) for the determination of maximal power output. Participants subsequently performed three 20-min constant load exercise trials: (1) arm-cycling at 50% of the ergometer-specific maximal power output (41 ± 9 W), (2) leg-cycling at 50% of the ergometer-specific maximal power output (122 ± 26 W), and (3) leg-cycling at the same absolute power output as the submaximal arm-cycling trial (41 ± 9 W). An executive function task was completed before, immediately after and 15-min after each exercise test. Exhaustive leg-cycling increased reaction time (p 0.05). Improvements in reaction time following arm-cycling were maintained for at least 15-min post exercise (p = 0.008, d = -0.73). Arm and leg-cycling performed at the same relative intensity elicit comparable improvements in cognitive performance. These findings suggest that individuals restricted to arm exercise possess a similar capacity to elicit an exercise-induced cognitive performance benefit

THE FUTURE OF NANOTECHNOLOGIES

Nanotechnology is the first major worldwide research initiative of the 21st century. Nanotechnologies are applied to cross industrial problems and are a general purpose technology that acts as both a basis for technology solutions or at the convergence of other enabling technologies, like biotechnologies, computational sciences, physical sciences, communication technologies, cognitive sciences, social psychology and other social sciences. Nanotechnologies are pervasive solution vectors in our economic environment. It is necessary to develop new methods to assess nanotechnologies development to better understand nanotechnology based innovation. As general purpose and enabling technologies, nanotechnologies reveal commercialization processes, from start-ups to large firms in collaboration with public sector research, and which lead to changing patterns of industrial organization which influence public policy initiatives to foster their development.Nanotechnology; general purpose technology; pan-industrial; convergence; hybridization; commercialization

GEOGRAPHIC PROFILE OF HEALTHCARE NEEDS AND NON-ACUTE HEALTHCARE SUPPLY IN IRELAND. ESRI RESEARCH SERIES NUMBER 90 JULY 2019

This report provides evidence on the supply of and need for non-acute primary, community and long-term care across geographic areas in Ireland in 2014. This is the first report to be published from the Health Research Board-funded project ‘An inter-sectoral analysis by geographic area of the need for and the supply and utilisation of health services in Ireland’. This report provides the most comprehensive evidence on the geographic distribution of primary, community and long-term care supply to have been published for Ireland to date. Overall, the report finds significant inequalities in the supply of primary, community and longterm care services across counties in Ireland.1 The findings have important implications for future planning of the Irish health system. The overall objective of the project is to provide evidence to inform policymakers about the shift of care, where appropriate, from the acute hospital setting to nonacute care settings. This project is undertaken in the context of significant system reforms in recent years that aimed to, among other things, achieve greater integration in the Irish healthcare system via shifting care, where appropriate, from acute to non-acute settings and building capacity in primary, community and longterm care. The project sets out to provide detailed evidence on supply of services in the non-acute sector, compares supply across regions to identify where nonacute care supply is particularly scarce, and provides evidence on how acute and non-acute services interact, and substitute, within the Irish health and social care system. Evidence generated from this project is of particular relevance in the context of the current Sláintecare strategy (Houses of the Oireachtas Committee on the Future of Healthcare, 2017), a cross-party plan aimed at delivering sustainable and equitable health and social care services in Ireland

Culture of airway epithelial cells from neonates sampled within 48-hours of birth

Peer reviewedPublisher PD

A revision of the ‘coelophysoid-grade’ theropod specimen from the Lower Jurassic of the Isle of Skye (Scotland)

The broadest diversification of early predatory dinosaurs is represented by the ‘coelophysoid-grade’ neotheropods, but their Hettangian–Sinemurian (c. 191–201 Ma) record is scarce worldwide. More information is needed to shed light on the evolution of this dinosaur group after the end-Triassic mass extinction (c. 201 Ma). Here we revisit the anatomy and phylogeny of one of these earliest Jurassic neotheropod specimens, an isolated partial tibia from the lower Sinemurian of the Isle of Skye (Scotland) that was previously identified as probably closely related to Liliensternus liliensterni and coelophysids. However, we found that the Skye specimen is positioned in the branch leading to Averostra (Ceratosauria + Tetanurae), in a polytomy with Sarcosaurus woodi from the late Hettangian–lower Sinemurian of central England and a clade composed of Tachiraptor admirabilis and Averostra. The morphology of the Skye specimen is congruent with that of referred specimens of Sarcosaurus woodi, but because it probably represents a skeletally immature specimen, we assign it to cf. Sarcosaurus woodi. The Skye specimen increases the number of averostran-line neotheropod specimens recorded in the Lower Jurassic of Europe and current evidence indicates that these forms, and not coelophysoids, were relatively common in this part of the world at that time

Proteasome inhibitor-based therapy for antibody-mediated rejection

The development of donor-specific anti-human leukocyte antigen antibodies (DSAs) following renal transplantation significantly reduces long-term renal graft function and survival. The traditional therapies for antibody-mediated rejection (AMR) have provided inconsistent results and transient effects that may be due to a failure to deplete mature antibody-producing plasma cells. Proteasome inhibition (PI) is a novel AMR therapy that deletes plasma cells. Initial reports of PI-based AMR treatment in refractory rejection demonstrated the ability of bortezomib to deplete plasma cells producing DSA, reduce DSA levels, provide histological improvement or resolution, and improve renal allograft function. These results have subsequently been confirmed in a multicenter collaborative study. PI has also been shown to provide effective primary AMR therapy in case reports. Recent studies have demonstrated that PI therapy results in differential responses in early and late post-transplant AMR. Additional randomized studies are evaluating the role of PI in transplant induction, acute AMR, and chronic rejection in renal transplantation. An important theoretical advantage of PI-based regimens is derived from several potential strategies for achievement of synergy

A profile of physiotherapy supply in Ireland. ESRI Research Bulletin, 2018/05

Physiotherapy is an important therapy service that is provided in acute (hospitals) and in non-acute (primary and community care, nursing homes etc.) settings. In order to understand where resources are most needed, policymakers need information on how many physiotherapists are working in Ireland and where they are located. However, there is a lack of information on acute and non-acute physiotherapy supply in Ireland across public and private settings, owing largely to the absence of a comprehensive central register. This makes it difficult not only to compare the availability of physiotherapists across counties in Ireland, but also to examine Irish supply in an international context. This paper quantifies the total supply of physiotherapists working in Ireland, disaggregated by their setting (acute and non-acute) and sector (public and private). In cases where individual physiotherapists work in different settings and sectors, we apportion their workload accordingly. This paper also estimates for each county the number of non-acute physiotherapists working in the community to find out where there is a low supply of therapists

Child Maltreatment Histories Among Female Inmate Reporting Inmate on Inmate Sexual Victimization in Prison: The Mediating Role of Emotion Dysregulation

Despite data indicating that child maltreatment (CM) in various forms is associated with adult sexual victimization among community women, few studies have explicitly explored how types of CM might relate to prison sexual victimization. Because little is known about how CM might give rise to prison sexual victimization, the present study also examined emotion dysregulation emanating from early abuse experiences as a potential mediator in the link between early CM and inmate-on-inmate prison sexual victimization. Approximately 168 incarcerated women completed self-report inventories assessing various types of childhood maltreatment, emotion dysregulation, and coerced or forced sexual experiences in prison. Nearly 77% of the sample endorsed experiencing at least one form of CM, with 64% of inmates reporting that they experienced two or more forms of CM. Approximately 9% of inmates reported sexual coercion and 22% reported a forced sexual experience in prison. Each form of CM was associated with prison sexual coercion; however, fewer associations emerged between CM and forced prison sexual experiences. Emotion dysregulation was found to mediate links between CM, particularly co-occurring CM, and sexual coercion in prison, but it was unrelated to forced prison sexual experiences. Implications are discussed

Child Maltreatment Histories Among Female Inmate Reporting Inmate on Inmate Sexual Victimization in Prison: The Mediating Role of Emotion Dysregulation

Despite data indicating that child maltreatment (CM) in various forms is associated with adult sexual victimization among community women, few studies have explicitly explored how types of CM might relate to prison sexual victimization. Because little is known about how CM might give rise to prison sexual victimization, the present study also examined emotion dysregulation emanating from early abuse experiences as a potential mediator in the link between early CM and inmate-on-inmate prison sexual victimization. Approximately 168 incarcerated women completed self-report inventories assessing various types of childhood maltreatment, emotion dysregulation, and coerced or forced sexual experiences in prison. Nearly 77% of the sample endorsed experiencing at least one form of CM, with 64% of inmates reporting that they experienced two or more forms of CM. Approximately 9% of inmates reported sexual coercion and 22% reported a forced sexual experience in prison. Each form of CM was associated with prison sexual coercion; however, fewer associations emerged between CM and forced prison sexual experiences. Emotion dysregulation was found to mediate links between CM, particularly co-occurring CM, and sexual coercion in prison, but it was unrelated to forced prison sexual experiences. Implications are discussed