European Paediatric Formulation Initiative (EuPFI)-Formulating Ideas for Better Medicines for Children.

© American Association of Pharmaceutical Scientists 2016, published by Springer US, available online at doi: https://doi.org/10.1208/s12249-016-0584-1The European Paediatric Formulation Initiative (EuPFI), founded in 2007, aims to promote and facilitate the preparation of better and safe medicines for children through linking research and information dissemination. It brings together the capabilities of the industry, academics, hospitals, and regulators within a common platform in order to scope the solid understanding of the major issues, which will underpin the progress towards the future of paediatric medicines we want.The EuPFI was formed in parallel to the adoption of regulations within the EU and USA and has served as a community that drives research and dissemination through publications and the organisation of annual conferences. The membership and reach of this group have grown since its inception in 2007 and continue to develop and evolve to meet the continuing needs and ambitions of research into and development of age appropriate medicines. Five diverse workstreams (age-appropriate medicines, Biopharmaceutics, Administration Devices, Excipients and Taste Assessment & Taste Masking (TATM)) direct specific workpackages on behalf of the EuPFI. Furthermore, EuPFI interacts with multiple diverse professional groups across the globe to ensure efficient working in the area of paediatric medicines. Strong commitment and active involvement of all EuPFI stakeholders have proved to be vital to effectively address knowledge gaps related to paediatric medicines, discuss potential areas for further research and identify issues that need more attention and analysis in the future.Peer reviewedFinal Accepted Versio

The evolutionary trend in airborne and satellite radar altimeters

The manner in which airborne and satellite radar altimeters developed and where the trend is leading was investigated. The airborne altimeters have progressed from a broad beamed, narrow pulsed, nadir looking instrument, to a pulse compressed system that is computer controlled, to a scanning pencil beamed system which produce a topographic map of the surface beneath the aircraft in real time. It is suggested that the airborne systems lie in the use of multiple frequencies. The satellite altimeters evolve towards multifrequency systems with narrower effective pulses and higher pulse compression ratios to reduce peak transmitted power while improving resolution. Applications indicate wide swath systems using interferometric techniques or beam limited systems using 100 m diameter antennas

New ammonia masers towards NGC6334I

We report the detection of new ammonia masers in the non-metastable (8,6) and (11,9) transitions towards the massive star forming region NGC6334I. Observations were made with the ATCA interferometer and the emitting region appears unresolved in the 2.7" x 0.8" beam, with deconvolved sizes less than an arcsecond. We estimate peak brightness temperatures of 7.8 x 10^5 and 1.2 x 10^5 K for the (8,6) and (11,9) transitions, respectively. The masers appear coincident both spatially and in velocity with a previously detected ammonia (6,6) maser. We also suggest that emission in the (10,9), (9,9) and (7,6) transitions may also be masers, based on their narrow line widths and overlapping velocity ranges with the above masers, as observed with the single-dish Mopra radiotelescope

Towards a Theory of Practice: Critical Transdisciplinary Multiliteracies

About the book: Education institutions and organizations throughout the world are currently being held accountable for achieving and maintaining historically unmatched standards of academic quality and performance. Accreditation bodies; policy makers; boards of trustees; and teacher, parent, and student groups all place educational institutions and organizations under unprecedented accountability pressures. The aim of this volume is to explore and better understand how these pressures are impacting a broad range of social and cultural issues and, subsequently, how these issues impact student motivation and learnin

Specific wavelength colorimeter

A self contained, specific wavelength, single beam colorimeter is described for direct spectrophotometric measurement of the concentration of a given solute in a test sample. An electrical circuit employing a photoconductive cell converts the optical output into a linear, directly readable meter output. The colorimeter is simple to operate and is adapted for use in zero gravity conditions. In a specific application, the colorimeter is designed to analyze the concentration of iodine in potable water carried aboard a space vehicle such as the 4B stage of Skylab

HeI in the central Giant HII Region of NGC 5253. A 2D observational approach to collisional and radiative transfer effects

ABRIDGED: NGC5253 is an ideal laboratory for detailed studies of starburst galaxies. We present for the first time in a starburst galaxy a 2D study of the spatial behavior of collisional and radiative transfer effects in He^+. The HeI lines are analysed based on data obtained with FLAMES and GMOS. Collisional effects are negligible for transitions in the singlet cascade while relatively important for those in the triplet cascade. In particular, they can contribute up to 20% of the flux in the HeIl7065 line. Radiative transfer effects are important over an extended and circular area of 30pc in diameter centered at the Super Star Clusters. HeI abundance, y^+, has been mapped using extinction corrected fluxes of six HeI lines, realistic assumptions for T_e, n_e, and the stellar absorption equivalent width as well as the most recent emissivities. We found a mean of 10^3 y^+ ~80.3 over the mapped area. The relation between the excitation and the total helium abundance, y_tot, is consistent with no abundance gradient. Uncertainties in the derivation of He abundances are dominated by the adopted assumptions. We illustrated the difficulty of detecting a putative He enrichment due to the presence of Wolf-Rayet stars in the main GHIIR. Data are marginally consistent with an excess in the N/He ratio in the N enriched area of the order of both, the atmospheric N/He ratios in WR stars and the uncertainties estimated for the N/He ratios.Comment: Accepted in Astronomy and Astrophysics; the emissivities presented in the Corrigendum, Porter et al. 2013, arXiv:1303.5115, have been include

Review of operational aspects of initial experiments utilizing the U.S. MLS

An exercise to support the Federal Aviation Administration in demonstrating the U.S. candidate for an international microwave landing system (MLS) was conducted by NASA. During this demonstration the MLS was utilized to provide the TCV Boeing 737 research airplane with guidance for automatic control during transition from conventional RNAV to MLS RNAV in curved, descending flight; flare; touchdown; and roll-out. Flight profiles, system configuration, displays, and operating procedures used in the demonstration are described, and preliminary results of flight data analysis are discussed. Recent experiences with manually controlled flight in the NAFEC MLS environment are also discussed. The demonstration shows that in automatic three-dimensional flight, the volumetric signal coverage of the MLS can be exploited to enable a commercial carrier class airplane to perform complex curved, descending paths with precision turns into short final approaches terminating in landing and roll-out, even when subjected to strong and gusty tail and cross wind components and severe wind shear

Maser Source Finding Methods in HOPS

The {\bf H}$_2${\bf O} Southern Galactic {\bf P}lane {\bf S}urvey (HOPS) has observed 100 square degrees of the Galactic plane, using the Mopra radio telescope to search for emission from multiple spectral lines in the 12\,mm band (19.5\,--\,27.5\,GHz). Perhaps the most important of these spectral lines is the 22.2\,GHz water maser transition. We describe the methods used to identify water maser candidates and subsequent confirmation of the sources. Our methods involve a simple determination of likely candidates by searching peak emission maps, utilising the intrinsic nature of water maser emission - spatially unresolved and spectrally narrow-lined. We estimate completeness limits and compare our method with results from the {\sc Duchamp} source finder. We find that the two methods perform similarly. We conclude that the similarity in performance is due to the intrinsic limitation of the noise characteristics of the data. The advantages of our method are that it is slightly more efficient in eliminating spurious detections and is simple to implement. The disadvantage is that it is a manual method of finding sources and so is not practical on datasets much larger than HOPS, or for datasets with extended emission that needs to be characterised. We outline a two-stage method for the most efficient means of finding masers, using {\sc Duchamp}.Comment: 8 pages, 1 table, 4 figures. Accepted for publication in PASA special issue on Source Finding & Visualisatio

Aggregating Dependency Graphs into Voting Agendas in Multi-Issue Elections

Many collective decision making problems have a combinatorial structure: the agents involved must decide on multiple issues and their preferences over one issue may depend on the choices adopted for some of the others. Voting is an attractive method for making collective decisions, but conducting a multi-issue election is challenging. On the one hand, requiring agents to vote by expressing their preferences over all combinations of issues is computationally infeasible; on the other, decomposing the problem into several elections on smaller sets of issues can lead to paradoxical outcomes. Any pragmatic method for running a multi-issue election will have to balance these two concerns. We identify and analyse the problem of generating an agenda for a given election, specifying which issues to vote on together in local elections and in which order to schedule those local elections