Policy coordination and financial intermediaries

Summary of proceedings from the 1986 Fall Academic Conference sponsored by the Federal Reserve Bank of San FranciscoMonetary policy ; Monetary policy - United States ; International economic relations ; Bank supervision ; Financial institutions

Attitude determination of the spin-stabilized Project Scanner spacecraft

Attitude determination of spin-stabilized spacecraft using star mapping techniqu

Neural precursor cells derived from induced pluripotent stem cells exhibit reduced susceptibility to infection with a neurotropic coronavirus.

The present study examines the susceptibility of mouse induced pluripotent stem cell-derived neural precursor cells (iPSC-NPCs) to infection with the neurotropic JHM strain of mouse hepatitis virus (JHMV). Similar to NPCs derived from striatum of day 1 postnatal GFP-transgenic mice (GFP-NPCs), iPSC-derived NPCs (iPSC-NPCs) are able to differentiate into terminal neural cell types and express MHC class I and II in response to IFN-γ treatment. However, in contrast to postnatally-derived NPCs, iPSC-NPCs express low levels of carcinoembryonic antigen-cell adhesion molecule 1a (CEACAM1a), the surface receptor for JHMV, and are less susceptible to infection and virus-induced cytopathic effects. The relevance of this in terms of therapeutic application of NPCs resistant to viral infection is discussed

Traveling-wave photodetector has sub-nanosecond response

Mercury-doped germanium photodetector uses waveguide which increases the absorption of microwave energy within the photodetectors. Waveguide and photodetector are placed in liquid helium Dewar and cooled. A carbon dioxide laser is light source and klystron provides microwave energy. Measured response times are approximately 1 nanosecond

A Stellar Dynamical Mass Measurement of the Black Hole in NGC 3998 from Keck Adaptive Optics Observations

We present a new stellar dynamical mass measurement of the black hole in the nearby, S0 galaxy NGC 3998. By combining laser guide star adaptive optics observations obtained with the OH-Suppressing Infrared Imaging Spectrograph on the Keck II telescope with long-slit spectroscopy from the Hubble Space Telescope and the Keck I telescope, we map out the stellar kinematics on both small spatial scales, well within the black hole sphere of influence, and on large scales. We find that the galaxy is rapidly rotating and exhibits a sharp central peak in the velocity dispersion. Using the kinematics and the stellar luminosity density derived from imaging observations, we construct three-integral, orbit-based, triaxial stellar dynamical models. We find the black hole has a mass of M_BH = (8.1_{-1.9}^{+2.0}) x 10^8 M_sun, with an I-band stellar mass-to-light ratio of M/L = 5.0_{-0.4}^{+0.3} M_sun/L_sun (3-sigma uncertainties), and that the intrinsic shape of the galaxy is very round, but oblate. With the work presented here, NGC 3998 is now one of a very small number of galaxies for which both stellar and gas dynamical modeling have been used to measure the mass of the black hole. The stellar dynamical mass is nearly a factor of four larger than the previous gas dynamical black hole mass measurement. Given that this cross-check has so far only been attempted on a few galaxies with mixed results, carrying out similar studies in other objects is essential for quantifying the magnitude and distribution of the cosmic scatter in the black hole mass - host galaxy relations.Comment: 19 pages, 15 figures, accepted for publication in Ap

Decomposing socioeconomic inequality in child vaccination: Results from Ireland

Background There is limited knowledge of the extent of or factors underlying inequalities in uptake of childhood vaccination in Ireland. This paper aims to measure and decompose socioeconomic inequalities in childhood vaccination in the Republic of Ireland. Methods The analysis was performed using data from the first wave of the Growing Up in Ireland survey, a nationally representative survey of the carers of over 11,000 nine-month old babies collected in 2008 and 2009. Multivariate analysis was conducted to explore the child and parental factors, including socioeconomic factors that were associated with non-vaccination of children. A concentration index was calculated to measure inequality in childhood vaccination. Subsequent decomposition analysis identified key factors underpinning observed inequalities. Results Overall the results confirm a strong socioeconomic gradient in childhood vaccination in the Republic of Ireland. Concentration indices of vaccination (CI = −0.19) show a substantial pro-rich gradient. Results from the decomposition analysis suggest that a substantial proportion of the inequality is explained by household level variables such as socioeconomic status, household structure, income and entitlement to publicly funded care (29.9%, 24% 30.6% and 12.9% respectively). Substantial differences are also observed between children of Irish mothers and immigrant mothers from developing countries. Conclusions Vaccination was less likely in lower than in higher income households. Access to publicly funded services was an important factor in explaining inequalities

Identifying the Optimal Age to Perform Newborn Screening for Hearing Loss in Uganda

Background: Permanent congenital hearing loss affects up to 6/1000 births in developing countries. Currently, in Uganda there is no newborn screening for hearing loss (NSHL) program and no published work on this topic. Within the existing healthcare system there are two opportunities to deliver screening, at birth or 6 weeks of age when infants receive their immunizations. Aim: This study explored the outcomes of otoacoustic emission (OAE) testing in infants at birth and 6 weeks of age, to identify the optimal age for screening. Subjects and Methods: This cross‑sectional pilot study recruited 60 consecutive infants from two health centres in Kampala, Uganda. Thirty infants were newborns recruited from the postnatal ward and 30 were aged 4–8 weeks from the immunization clinic, we performed OAE testing on all infants. Results: The results showed 56.7% (17/30) of newborn infants passed OAE testing compared with 90.0% (27/30) of the immunization infants, P < 0.01. Furthermore, of the 11 newborn infants aged ≥24 h of age 90.9% (10/11) passed, compared with the 19 infants <24 h of age where 37% (7/19) passed, P < 0.01. Conclusions: This study demonstrates a higher pass rate for OAE testing for infants ≥24 h of age compared to those <24 h of age. The overall lower pass rate of the newborn infants could be due to external ear debris and middle ear fluid compromising the OAE testing. These findings would support a NSHL programme in Uganda that offers screening to infants ≥24 h of age, to maximize the cost‑effectiveness of the program.Keywords: Hearing loss, Newborn, Screenin